Publications

Link to Mühlberger lab publications:

https://www.ncbi.nlm.nih.gov/myncbi/elke.muehlberger.1/bibliography/public/

Filovirus book

https://link.springer.com/book/10.1007%2F978-3-319-68948-7

Select Publications (Mühlberger lab members highlighted in blue)

    Olejnik, J*, Hume, AJ*, Ross, SJ, Scoon, WA, Seitz, S, White, MR, Slutzky, B, Yun, NE, Mühlberger, E. Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses. Pathogens 2023, 12, 952. https://doi.org/10.3390/pathogens12070952. *equal contribution

    Jalloh, S*, Olejnik, J*, Berrigan, J, Nisa, A., Suder, EL, Akiyama, H, Lei, M, Tyagi, S, Bushkin, Y, Mühlberger, E#, Gummuluru, S# CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory response. PlosPathogens, 2022 Oct 24;18(10):e1010479. *equal contribution; #equal contribution.

    Scoon, WA, Mancio-Silva, L, Suder, EL, Villacorta-Martin, C, Lindstrom-Vautrin, J, Bernbaum, JG, Mazur, S, Johnson, RF, Olejnik, J, Flores, EY, Mithal, A, Wang, F, Hume, AJ, Kaserman, JE, March-Riera, S, Wilson, AA, Bhatia, SN, Mühlberger, E#, Mostoslavsky, G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Aug 25: S2213-6711(22)00412-X. PMID: 36084636.#corresponding authors.

    Kemenesi G, Tóth GE, Mayora-Neto M, Scott S, Temperton N, Wright E, Mühlberger E, Hume AJ, Suder EL, Zana B, Boldogh SA, Görföl T, Estók P, Lanszki Z, Somogyi BA, Nagy Á, Pereszlényi CI, Dudás G, Földes F, Kurucz K, Madai M, Zeghbib S, Maes P, Vanmechelen B, Jakab F. Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary. Nat Commun. 2022 Mar 31;13(1):1706. doi: 10.1038/s41467-022-29298-1. PMID: 35361761.

    Hume AJ#, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E.# Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Feb 4;18(2):e1010268. doi: 10.1371/journal.ppat.1010268. PMID: 35120176; PMCID: PMC8849519.#corresponding authors.

    Leon J*, Michelson DA*, Olejnik J*, Chowdhary K, Oh HS, Hume AJ, Galván-Peña S, Zhu Y, Chen F, Vijaykumar B, Yang L, Crestani E, Yonker LM, Knipe DM, Mühlberger E, Benoist C. A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune-epithelial interface. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2116853118. doi: 10.1073/pnas.2116853118. PMID: 34969849. *equal contribution.

    Mithal A*, Hume AJ*, Lindstrom-Vautrin J, Villacorta-Martin C, Olejnik J, Bullitt E, Hinds A, Mühlberger E#, Mostoslavsky G#. Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response. Stem Cell Reports. 2021 Apr 13. doi: https://doi.org/10.1016/j.stemcr.2021.02.019. PMID: 33852884. PMCID: PMC8042780. *equal contribution; #corresponding authors.

    Hekman RM*, Hume AJ*, Goel RK*, Abo KM, Huang J*, Blum BC*, Werder RB*, Suder EL*, Paul I*, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN#, Wilson AA#, Mühlberger E#, Emili A#. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 Dec 17;80(6):1104-1122.e9. doi: 10.1016/j.molcel.2020.11.028. PMID: 33259812. PMCID: PMC7674017. *equal contribution; #corresponding authors.

    Huang, J*, Hume AJ*, Abo KM*, Werder RB*, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA#, Mühlberger E#, Kotton DN#. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response.  Cell Stem Cell. 2020 Dec 3:S1934-5909(20)30459-8. doi: 10.1016/j.stem.2020.09.013. PMID: 32979316; PMCID: PMC7500949. *equal contribution; #corresponding authors.

    Knipe DM, Levy O, Fitzgerald KA, Mühlberger E. Ensuring vaccine safety. Science. 2020 Dec 11;370(6522):1274-1275. doi: 10.1126/science.abf0357. Epub 2020 Nov 17. PMID: 33203781.

    Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GG, Stuart LM, Lacy-Hulbert A. MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. Science. 2020 Aug 27:eabb3753. doi: 10.1126/science.abb3753. PMID: 32855215. MCID: PMC7665841.

    Hume AJ, Mühlberger E. Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family. J Mol Biol. 2019 Oct 4;431(21):4290-4320. doi: 10.1016/j.jmb.2019.06.029. Epub 2019 Jun 29. Review. PMID: 31260690. PMCID: PMC6879820.

    Deflubé LR*, Cressey TN*, Hume AJ*, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R#, Mühlberger E#. Ebolavirus polymerase uses an unconventional genome replication mechanism. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8535-8543. doi: 10.1073/pnas.1815745116. Epub 2019 Apr 8. PMID: 30962389. PMCID: PMC6486738. *equal contribution; #corresponding authors.

    Olejnik J, Hume AJ, Mühlberger E. Toll-like receptor 4 in acute viral infection: Too much of a good thing. PLoS Pathog. 2018 Dec;14(12):e1007390. doi: 10.1371/journal.ppat.1007390. eCollection 2018 Dec. Review. PMID: 30571771. PMCID: PMC6301565.

    Manhart WA, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Mühlberger E. A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses. Cell Rep. 2018 Sep 4;24(10):2573-2580.e4. doi: 10.1016/j.celrep.2018.08.008. PMID: 30184492. PMCID: PMC6159894.

    Olejnik J, Forero A, Deflubé LR, Hume AJ, Manhart WA, Nishida A, Marzi A, Katze MG, Ebihara H, Rasmussen AL, Mühlberger E. Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages. J Virol. 2017 Jun 1;91(11). doi: 10.1128/JVI.00179-17. Print 2017 Jun 1. PMID: 28331091. PMCID: PMC5432886.