Boston University’s Chemical Compound Libraries
BU Today‘s profile of the Center for Molecular Discovery (CMD) highlights the work of Boston University chemists who create new chemical compounds and store them for future use in a chemical library. Like a traditional library, a chemical library catalogs and organizes its materials with access and preservation concerns in mind. You can find the CMD’s web site here.
To learn more about synthetic chemicals, you can use SciFinder‘s extensive database of chemical structures. If you want to read some of the papers written by BU chemists who work with the CMD, follow the links below (BU username and password needed):
- Alan T. Yeo, Spandan Chennmadhavuni, Adrian Whitty, John Porco, & Thomas D. Gilmore (2015). Inhibition of oncogenic transcription factor REL by the natural product derivative calafianin monomer 101 induces proliferation arrest and apoptosis in human B-lymphoma cell lines. Molecules, volume 20, pp. 7474-7494.
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Alexander J. Grenning, Jonathan H. Boyce, & John A. Porco, Jr. (2014). Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation. Journal of the American Chemical Society, volume 136, pp. 11799-11804.
- Elizabeth A. Villar, Dmitri Beglov, Spandan Chennamadhavuni, John A. Porco, Jr., Dima Kozokov, Sandor Vajda, & Adrian Whitty (2013). How proteins bind macrocycles. Nature Chemical Biology, volume 10, pp. 723-731.