Publications

2023

Yanwu Wang^#, Ning Shen^#, Gervase Spurlin, Sovannarith Korm, Sarah Huang, Nicole M. Anderson, Leah N. Huiting, Hudan Liu, Hui Feng. α-ketoglutarate-mediated DNA demethylation sustains T-acute lymphoblastic leukemia upon TCA cycle targeting. Cancers. 2022. Jun 16;14(12):2983. ^#equal contribution.

Chinyere Kemet^#, Emily Hill^#, Hui Feng. Fishing for drugs.  eLife. 2022 11:e76632DOI:10.7554/eLife.76632

2021

Ning Shen^#, Sovannarith Korm^#, Theodoros Karantanos, Dun Li, Xiaoyu Zhang, Eleni Ritou, Hanfei Xu, Andrew Lam, Justin English, Wei-Xing Zong, Ching-Ti Liu, Orian Shirihai, Hui Feng. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Communications Biology. 2021. Nov 16;4(1):1289 ^#equal contribution.

Joseph Friedlander†, Ning Shen†, Aozuo Zeng, Sovannarith Korm, and Hui Feng. Failure to Guard: Mitochondrial Protein Quality Control in Cancer. International Journal of Molecular Sciences. 2021 Aug 2;22(15):8306. PMCID: PMC8348654 ^†equal contribution

Nicole M. Anderson, Xiaodan Qin, Jennifer M. Finan, Andrew Lam, Jacob Athoe, Rindert Missiaen, Nicolas Skuli, Annie Kennedy, Amandeep S. Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A. Thomas Look, Guoliang Qing, M. Celeste Simon^*, Hui Feng^*. Metabolic Enzyme DLST Promotes Tumor Aggression and Unveils a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer Research. 2021. Sep 1;81(17):4417-4430. *Co-corresponding author.

Kelly Y.Z. Miao, Grace Y. Kim^#, Grace K. Meara^#, Xiaodan Qin, and Hui Feng. Tipping the scales with zebrafish to understand adaptive tumor immunity. Frontier in Cell and Developmental Biology  2021. May 20: 9: 660969. PMCID: PMC8173129. ^#equal contribution. 

Yun Zhou#, Haiwei Lian#, Ning Shen, Sovannarith Korm, Andrew Lam, Leah N. Huiting, Dun Li, Kelly Yizi Miao, Olivia Layton, Aozhuo Zeng, Esther Landesman-Bollag, David C. Seldin, Hui Fu, Li Hong*, Hui Feng*. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 2021. May 1;106(5):1461-1465. PMCID: PMC8094085. #equal contribution. *Co-corresponding author.

Wenjun Shao, Kivilcim Kilic, Wenqing Yin, Gregory Wirak, Xiaodan Qin, Hui Feng, David Boas, Christopher V Gabel, Ji Yi. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quantitative Imaging in Medicine and Surgery. 2021. Mar 11(3):983-997. PMCID:PMC7829172.

2020

Xiaodan Qin, William D. Denton^*, Leah N. Huiting^*, Kaylee S. Smith, Hui Feng. Unraveling the Regulatory Role of Endoplasmic-Reticulum-Associated Degradation in Tumor Immunity. Critical Reviews in Biochemistry and Molecular Biology. 2020 Aug;55(4):322-353.^*equal contribution. 

Xiaodan Qin^*, Fabrice J.F. Laroche^*, Saquib Ahmed M. A. Peerzade, Andrew Lam, Igor Sokolov, Hui Feng. In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish. Journal of Visualized Experiments. 2020 May 8;(159). ^*equal contribution.

Weiye Song, Alex Matlock, Sipei Fu, Xiaodan Qin, Hui Feng, Christopher V. Gabel, Lei Tian, Ji Yi. LED array reflectance microscopy for scattering-based multi-contrast imaging. Optics Letters. 2020 Apr 1;45(7):1647-1650. 

Jue Jiang, Jingchao Wang, Ming Yue, Xiaolian Cai, Tianci Wang, Hexiu Su, Yanwu Wang, Meng Han, Yingchi Zhang, Xiaofan Zhu, Peng Jiang, Peng Li, Yonghua Sun, Wuhan Xiao, Hui Feng, Guoliang Qing, Hudan Liu. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T Cell Leukemogenesis. 2020. Cancer Cell. Feb 10;37(2):200-215.e5.

Chinaemere Igwebuike, Julia Yaglom, Leah Huiting, Hui Feng, Joshua Campbell, Zhiyong Wang, Andrea Havasi, David Pimentel, Michael Sherman, Steven Borkan. Cross Organelle Stress Response Disruption Promotes Gentamicin-Induced Proteotoxicity. 2020. Cell Death & Disease. Apr 3;11(4):217.

Chen Khuan Wong, Arthur Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Abdolmaleky, Balázs Győrffy, Hui Feng, and Sam Thiagalingam. Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan. 2020. Molecular Cancer Research. Mar;18(3):414-423.

2019

Jie Jiang,^# Sankalp Srivastava,^# Gretchen Seim, Natalya N. Pavlova, Bryan King, Lihua Zou, Chi Zhang, Minghua Zhong, Hui Feng, Reuben Kapur, Ronald C. Wek, Jing Fan, Ji Zhang. Promoter demethylation of the asparagine synthetase gene is required for an ATF4-dependent adaptation to asparagine depletion. 2019. Journal of Biochemistry. Dec 6;294(49):18674-18684. ^#equal contribution.

Saquib Ahmed M. A. Peerzade, Xiaodan Qin^#, Fabrice J.F. Laroche^#, Shajesh Palantavida, Maxim Dokukin, Berney Peng, Hui Feng^*, Igor Sokolov^*. Ultrabright fluorescent silica nanoparticles for in vivo targeting xenografted human tumors and cancer cells in zebrafish. 2019. Nanoscale. Nov 28;11(46):22316-22327.  ^#equal contribution. *co-corresponding author.

Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Woulter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, and Wei-Xing Zong. Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. 2019. Cell Reports. Oct 29;29(5):1287-1298.e6.

Berney Peng, Mohammad Almeqdadi, Fabrice Laroche, Shajesh Palantavida, Maxim Dokukin, Jatin Roper, Omer H. Yilmaz, Hui Feng, Igor Sokolov. Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. 2019. Materials Today. Mar 23;16-25.

2018

Berney Peng, Mohammad Almeqdadi, Fabrice Laroche, Shajesh Palantavida, Maxim Dokukin, Jatin Roper, Omer H. Yilmaz, Hui Feng, Igor Sokolov. Data on Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. 2018. Data brief. Dec 18;22:383-391.

Hexiu Su, Juncheng Hu, Liang Huang, Yang Yang, Morgan Thenoz, Anna Kuchmiy, Yufeng Hu, Peng Li, Hui Feng, Yu Zhou, Tom Taghon, Pieter Van Vlierberghe, Guoliang Qing, Zhichao Chen, Hudan Liu. SHQ1 regulation of pre-RNA splicing is required for T-lymphoblastic leukemia cell survival. 2018. Nature Communications. Oct 15;9(1):4281.

Vinay Kartha, Khalid Alamoud, Khikmet Sadykov, Bach-Cuc Nguyen, Fabrice Laroche, Hui Feng, Jina Lee, Sara Pai, Xaralabos Varelas, Ann Marie Egloff, Jennifer E. Snyder-Cappione, Anna C. Belkina, Manish V. Bais, Stefano Monti and Maria Kukuruzinska. Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer. 2018. Genome Medicine. Jul 20;10(1):54.

Supraja Narasimhan, Elizabeth Stanford Zulick, Olga Novikov, Ashley J. Parks, Jennifer J. Schlezinger, Zhongyan Wang, Fabrice Laroche, Hui Feng, Francesca Mulas, Stefano Monti and David H. Sherr. Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. 2018. International Journal of Molecular Sciences. 15(5): 1388.

Leah N. Huiting, Yasmina Samaha, Guanglan Zhang, Justine E. Roderick, Boey Li, Nicole M. Anderson, Yanwu Wang, Lan Wang, Fabrice J.F. Laroche, Jonwon Choi, Ching-ti Liu, Michelle A. Kelliher and Hui Feng. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. 2018. Leukemia. Nov;32(11):2339-2351.

2017

Nicole M. Anderson#, Patrick Mucka#, Joseph Kern and Hui Feng. The Emerging Role and Targetability of the TCA Cycle in Cancer Metabolism. 2017.  Protein & Cell. Jul 26. doi: 10.1007/s13238-017-0451-1. [Epub ahead of print] #equal contribution.

Xingjun Liu, Yue-Sheng Li, Susan A. Shinton, Jennifer Rhodes, Lingjuan Tang, Hui Feng, Cicely A. Jette, A. Thomas Look, Kyoko Hayakawa, and Richard R. Hardy.  Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. 2017. Journal of Immunology. Sep 1;199(5):1706-1715.

Wei-Siang Liau, Shi Hao Tan, Phuong Ngoc, Chelsia Wang, Vinay Tergaonkar, Hui Feng, Zhiyuan Gong, Motomi Osato, A. Thomas Look, and Takaomi Sanda. Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia. 2017. Leukemia. Aug;31(8):1798-1807.

Haiwei Lian, Dun Li, Yun Zhou, Esther Landesman-Bollag, Guanglan Zhang, Nicole M. Anderson, Kevin C. Tang, Justine E. Roderick, Michelle A. Kelliher, David C. Seldin, Hui Fu* and Hui Feng*. CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. 2017. Haematologica. Jan;102(1):e17-e21. *co-senior author.

2016

Nicole M. Anderson, Dun Li, Hongling Peng, Fabrice J.F. Laroche, Marc R. Mansour, Evisa Gjini, Miriam Aioub, Daniel J. Helman, Justine E. Roderick, Teresa Cheng, Itrat Harrold, Yasmina Samaha, Le Meng, Adam Amsterdam, Donna S. Neuberg, Travis T. Denton, Takaomi Sanda, Michelle A. Kelliher, Anurag Singh, A. Thomas Look, and Hui Feng. The TCA Cycle Transferase DLST is Important for MYC-mediated Leukemogenesis. 2016. Leukemia. 30(6):1365-74. 

Itrat Harrold,^¶ Seth Carbonneau,^¶ Bethany M. Moore, Gina Nguyen, Nicole M. Anderson, Amandeep S. Saini, John P. Kanki, Cicely A. Jette, and Hui Feng. Efficient Transgenesis Mediated by Pigmentation Rescue in Zebrafish. 2016. BioTechniques. 60(1):13-20. ¶equal contribution.

Nicholas R. Harrison^*, Fabrice J.F. Laroche^*, Alejandro Gutierrez, and Hui Feng. Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. 2016. Adv Exp Med Biol. 916:335-69. *equal contribution

2015

Sowmya Shivanna, Vipul C. Chitalia, Rosanna Meyer, Edward Hartsough, Manisha Mehta,  Itrat Harrold, Nicole M Anderson, Hui Feng, Lois E.H. Smith, Yan Jiang, Catherine E. Costello,  Nader Rahimi. Hypoxia-induced expression of Phosducin like 3 regulates expression of VEGFR-2 and promotes angiogenesis. 2015.  Angiogenesis. 18(4):449-62.

Sowmya Shivanna, Itrat Harrold, Moshe Shashar, Rosanna Meyer, Chrystelle Kiang, Jean Francis, Qing Zhao, Hui Feng, Elazer R. Edelman, Nader Rahimi, Vipul C. Chitalia. C-Cbl regulates nuclear β-catenin and angiogenesis through its Wnt mediated phosphorylation. 2015.  J. Bio. Chem. 290(20):12537-12546.

Leah Huiting, Fabrice J.F. Laroche, and Hui Feng. The zebrafish as a tool to cancer drug discovery. 2015. Aust. J. Pharmacol. Therap. 3(2).1069

2014

Alejandro Gutierrez, Hui Feng, Donna S. Neuberg, Oscar Calzada, Yi Zhou, David M. Langenau, and A. Thomas Look. 2014. Loss of function p53 mutations do not accelerate the onset of Myc-induced T-ALL in the zebrafish. Brit. J. Heamatol. 166(1):84-90.

Nicole M. Anderson^¶, Itrat Harrold^¶, Marc R. Mansour, Takaomi Sanda, Michael McKeown, Nicholas Nagykary, James E. Bradner, Guang Lan Zhang, A. Thomas Look*, Hui Feng*.  2014. BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more differentiated T-ALL cell lines.  Leukemia. 28(5):1145-8. ¶equal contribution. *co-senior author.

2012

Jessica S.Blackburn, Sali Liu, David M. Raiser, Sarah A. Martinez, Hui Feng, Nathan D. Meeker, Jeffery Gentry, Donna Neuberg, A Thomas Look, Sridhar Ramaswamy, Andre Bernards, Nikolaus S. Trede, David M Langenau. 2012. Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 26(9):2069-78. PMCID: PMC3435461

Shizhen Zhu, Jeong-Soo Lee, Feng Guo, Jimann Shin, Antonio R. Perez-Atayde, Jeffery L. Kutok, Scott J. Rodig, Donna S. Neuberg, Daniel Helman, Hui Feng, Rodney A. Stewart, Wenchao Wang, Rani E. George, John P. Kanki, A. Thomas Look. 2012. Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis, Cancer Cell. 21(3):362-73. PMCID: PMC3315700.

2011

Alejandro Gutierrez, Ruta Grebliunaite, Hui Feng, Elena Kozakewich, Shizhen Zhu, Feng Guo, Elspeth Payne, Marc Mansour, Suzanne E. Dahlberg, Donna S. Neuberg, Jeroen den Hertog, Edward V. Prochownik, Joseph R. Testa, Marian Harris, John P. Kanki, and A. Thomas Look. 2011. Pten Mediates Myc Oncogene Dependence in a Conditional Zebrafish Model of T-ALL. Journal of Experimental Medicine. 208(8):1595-603.

2010

Hui Feng, David L. Stachura, Richard M. White, Alejandro Gutierrez, Lu Zhang, Takaomi Sanda, Cicely A. Jette, Joseph R. Testa, Donna S. Neuberg, David M. Langenau, Jeffery L. Kutok, Leonard I. Zon, David Traver, Mark D. Fleming, John P. Kanki, A. Thomas Look. 2010. T-Lymphoblastic Lymphoma Cells Expres High Levels of BCL2, S1P1 and ICAM1 Leading to a Blockade of Tumor Cell Intravasation. Cancer Cell. 18: 353-366, PMCID: PMC3003429. (With News and Reviews in Cancer Cell. 18:297-299 and Science. 330: 891).

Dimple R. Bosu, Hui Feng, Kyoengwoo Min, Youngjo Kim, Matthew R. Wallenfang, and Edward T. Kipreos. 2010. C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues. Developmental Biology. 346(1):113-26, PMCID: PMC2955628.

2008

Jennifer Freeman, Craig Ceol, Hui Feng, David M. Langenau, Cassandra Belair, Howard M. Stern, Anhua Song, Barry H. Paw, A. Thomas Look, Yi Zhou, Leonard I. Zon, Charles Lee. 2008. Construction and Application of a Zebrafish Array CGH Platform. Genes, Chromosomes and Cancer 48(2):155-70, PMCID: PMC2605212.

2007

Hui Feng, David M. Langenau, Jennifer A. Madge, Andre Quinkertz, Alejandro Gutierrez, Donna S. Neuberg, John P. Kanki, A Thomas Look. 2007. Heat-shock induction of T-cell lymphoma/leukemia in conditional Cre/lox-regulated transgenic zebrafish. British Journal of Hematology 138(2):169-75.

Jihyun Kim, Hui Feng, Edward T. Kipreos. 2007. C. elegans CUL-4 prevents re-replication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Current Biology 17(11):966-72, PMCID: PMC1945017.

2005

David M. Langenau, Hui Feng, Stephane Berghmans, John P. Kanki, Jeffery L. Kutok, and A. Thomas Look. 2005. Cre/lox-regulated Transgenic Zebrafish Model with Conditional myc-induced T-Cell Acute Lymphoblastic Leukemia. Proceedings of the National Academy of Sciences. 102(17):6068-6073, PMCID: PMC1087915.

2003

Hui Feng and Edward T. Kipreos, 2003. Preventing DNA re-replication: Lessons learned from Yeasts, Worms, and Vertebrates. Landes Bioscience, Cell Cycle 2(5): 431-434.

Weiwei Zhong, Hui Feng, Fernando Santiago, and Edward T. Kipreos. 2003. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA replication licensing. Nature 423: 885-889. (With commentary in Nature 423:818-9. )

1999

Hui Feng, Weiwei Zhong, George Punkosdy, Subin Gu, Liang Zhou, Erin K. Seabolt, and Edward T. Kipreos. 1999. CUL-2 is required for the G1-to-S phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nature Cell Biology 1: 486-492.