New Application for Phosphoprotien Analysis Highlighted

The June 14 edition of Biochemistry published research by Associate Professor Dr. Erdjan Salih titled, “Quantitative Analysis of Cytokine-Induced Hepatocyte Nuclear Factor-4α Phosphorylation by Mass Spectrometry.”

The article highlights the first specific biomedical application in the area of surgery, systemic injury, and liver function of the new technology developed by Dr. Salih for phosphoprotein analysis. 

Said Dr. Salih, “This article introduces, for the first time, a new quantitative analysis of the state of dynamic phosphorylation of an important liver transcription factor, HNF-4, which regulates its function in response to ‘cytokine’ treatment.”

This research is also significant because of the interdisciplinary approach to biomedical science taken by the Department of Periodontology & Oral Biology and Department of Surgery at GSDM and BUSM respectively. Dr. Salih collaborated with BUSM Chief of Trauma and Professor Dr. Peter Burke and postdoctoral student Dr. Zhongyan Wang.

Full article text is available on the Biochemistry website.