Biomedicine
CAREER: Algorithms and Fundamental Limitations for Sparse Control
The proposal is to study the design of feedback control strategies which stabilize and steer systems by affecting them in only a few variables. The motivation comes from applications which are either large-scale or geographically distributed and therefore cannot be feasibly affected in many places. A primary motivating application is the control of metabolic chemical […]
AF: Small: Manifold optimization algorithms for protein-protein docking
Proteins are the major building blocks of the cell. Many proteins perform their function by interacting with other proteins. In a typical cell hundreds of thousands of different protein interactions take place. Characterizing these interactions helps elucidate how living organisms function at the molecular level, contributes towards the development of treatments against diseases such as […]
ABI Development: Utilization of Diverse Data in Exploring Protein-Protein Interactions
Each living cell is packed with proteins that continuously interact with each other in response to envirtonmental and other signals to control the cell’s growth and eventual fate. The analysis of such interactions is crucial for understanding signal transduction pathways that drive cell differentian during development and throughout the life an an organism. These pathways […]
CPS: FRONTIER: COLLABORATIVE RESEARCH: BIOCPS FOR ENGINEERING LIVING CELLS
Recent developments in nanotechnology and synthetic biology have enabled a new direction in biological engineering: synthesis of collective behaviors and spatio-temporal patterns in multi-cellular bacterial and mammalian systems. This will have a dramatic impact in such areas as amorphous computing, nano-fabrication, and, in particular, tissue engineering, where patterns can be used to differentiate stem cells […]
Interdisciplinary Team Sheds Light on How Proteins Bind
Finding Could Open Up New Drug Discovery Opportunities Over the past six years, an interdisciplinary team of College of Engineering faculty members—Professor Sandor Vajda (BME, SE), Research Assistant Professor Dima Kozakov (BME), Professor Yannis Paschalidis (ECE, SE) and Associate Professor Pirooz Vakili (ME, SE)—have been developing a set of powerful optimization algorithms for predicting the structures of complexes that form when […]
2012 IEEE International Symposium on Biomedical Imaging Travel Support Barcelona, Spain
The IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI) is a forum that has traditionally focused on the computational and modeling aspects of biomedical imaging. It emphasizes methodologies that have the potential to be applicable to multiple imaging modalities and to imaging at different scales. Topics include physical, biological and statistical modeling […]
ENG Researchers Partner with MIT Lincoln Laboratory on Advanced Imaging
Surveillance video from unmanned aerial vehicles (UAVs) generates a tremendous amount of data, making it difficult for ground controllers to identify and track suspicious activities in short order. But advanced techniques that Professor Venkatesh Saligrama (ECE, SE), in collaboration with a researcher at MIT Lincoln Laboratory, is developing to analyze airborne video imagery could enable […]
Refinement Methods for Protein Docking based on Exploring Multi-Dimensional Energ
All successful state-of-the-art protein docking methods employ a so called multistage approach. At the first stage of such approaches a rough energy potential is used to score billions of conformations. At a second stage, thousands of conformations with the best scores are retained and clustered based on a certain similarity metric. Cluster centers correspond to […]
IDBR: Simultaneous Tracking of Multiple Particles in Confocal Microscopy
This award is for the development of techniques for tracking multiple fluorescing particles simultaneously in a confocal microscope. The project will initially develop algorithms for tracking single fluorescent particles in vitro and inside living cells. Techniques from modern systems and control theory, including limited communication control and optimal estimation, will be built upon to enable […]