Peer Reviewed Publications:


Raeef Istfan, Carlos A. Gómez, Matthew Applegate, Dmitry Rozenberg, W. Darlene Reid, Darren Roblyer, “Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation,” Biomedical Optics Express 12, 4147-4162 (2021) link

Samuel S. Spink, Fei Teng, Vivian Pera, Hannah M. Peterson, Tim Cormier, Alexis Sauer-Budge, David Chargin, Sam Brookfield, Adam Eggebrecht, Naomi Ko, Darren Roblyer, “A high optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue,” Journal of Biomedical Optics, 26(6) 062708 (2 June 2021) link

M Applegate, R Amelard, C Gomez, Darren Roblyer, “Real-time handheld probe tracking and image formation using digital frequency-domain diffuse optical spectroscopy,” IEEE Transactions on Biomedical Engineering link

M Applegate, C Gómez, Darren Roblyer, “Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy,” Journal of Biomedical Optics. 26(3) 036007 (25 March 2021) link

S Tabassum, A Tank, F Wang, K Karrobi, C Vergato, IJ Bigio, DJ Waxman, Darren Roblyer “Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer.” Neoplasia, 23(3), 294-303 (2021) link

M Applegate, S Spink, Darren Roblyer “Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring.” Biomedical Optics Express, 12, 676-688 (2021) link


Y Zhao, A Pilvar, A Tank, H Petterson, J Jiang, JC Aster, JP Dumas, MC Pierce, Darren Roblyer, “Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.” Nature Communications 11, 5355 (2020). link

Sunil S, Evren Erdener S, Cheng X, Kura S, Tang J, Jiang J, Karrobi K, Kılıç K, Darren Roblyer, Boas DA. “Stroke core revealed by tissue scattering using spatial frequency domain imaging”. Neuroimage Clin. 2020 Dec 20;29:102539. PMID: 33385882. link

Stephen J. DeCamp, Victor M. K. Tsuda, Jacopo Ferruzzi, Stephan A. Koehler, John T. Giblin, Darren Roblyer, Muhammad H. Zaman, Scott T. Weiss, Ayşe Kılıç, Margherita De Marzio, Chan Young Park, Nicolas Chiu Ogassavara, Jennifer A. Mitchel, James P. Butler & Jeffrey J. Fredberg “Epithelial layer unjamming shifts energy metabolism toward glycolysis”. Scientific Reports 10, 18302 (2020). link

Darren Roblyer, “Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond,” J. Biomed. Opt. 25(10) 102703 (21 October 2020). link

Hannah M. Peterson, Anup Tank, David S. Geller, Rui Yang, Richard Gorlick, Bang H. Hoang, Darren Roblyer, “Characterization of bony anatomic regions in pediatric and adult healthy volunteers using diffuse optical spectroscopic imaging,” Journal of Biomedical Optics 25(8), 086002 (2020). link

MB Applegate, R Istfan, S Spink, A Tank, and Darren Roblyer “Recent advances in high speed diffuse optical imaging in biomedicine,” APL Photonics, 5, 040802 (2020). link

Anup Tank, Hannah M. Peterson, Vivian Pera, Syeda Tabassum, Anais Leproux, Thomas O’Sullivan, Eric Jones, Howard Cabral, Naomi Ko, Rita S. Mehta, Bruce J. Tromberg, Darren Roblyer “Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens,” Breast Cancer Research 22, 29 (2020). link

MB Applegate, K Karrobi, JP Angelo Jr., WM Austin, S Tabassum, E Aguénounon, K Tilbury, R Saager, S Gioux, Darren Roblyer, “OpenSFDI: an open-source guide for constructing a spatial frequency domain imaging system,” Journal of Biomedical Optics, 25(1) 016002 (2020) link


J Ferruzzi,M Sun, A Gkousioudi, A Pilvar, Darren Roblyer, Y Zhang, MH Zaman, “Compressive Remodeling Alters Fluid Transport Properties of Collagen Networks – Implications for Tumor Growth,” Scientific Reports, 9, 17151 (2019) link

K Karrobi, A Tank, V Pera, Darren Roblyer, “Diffuse and nonlinear imaging of multiscale vascular parameters for in vivo monitoring of preclinical mammary tumors,” Journal of Biophotonics, (2019) link

B Bungart, Y Cao, T Yang-Tran, S Gorsky, L Lan, Darren Roblyer, M O.Kock, L Cheng, T Masterson, Ji-Xin Cheng “Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography”, Biomedical Optics Express, 10(3), 1405-1419 (2019) link


Y Zhao, Y Deng, F Bao, Darren Roblyer , “A deep learning model for ultrafast multi-frequency optical property extractions for Spatial Frequency Domain Imaging (SFDI),” Optics Letters, 15;43(22):5669-5672.(2018) link

Y Zhao*, M Applegate*, R Istfan, A Pande, Darren Roblyer , “Quantitative real-time pulse oximetry with ultrafast frequency-domain diffuse optics and deep neural network processing,” Biomedical Optics Express, 9(12), 5997-6008 (2018). *shared first-authors link

JM Cochran, DR Busch, A Leproux, Z Zhang, TD O’Sullivan, AE Cerussi, PM Carpenter, R Mehta, Darren Roblyer, W Yang, KD Paulsen, B Pogue, S Jiang, PA Kaufman, SH Chung, M Schnall, BS Snyder, N Hylton, SA Carp, SJ Isakoff, D Mankoff, B Tromberg, AG Yodh, “Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment,” Journal of Biomedical Optics, 24(2), 0212025 (2018). link

CK Hayakawa, K Karrobi, V Pera, Darren Roblyer, V Venugopalan, “Optical sampling depth in the spatial frequency domain,” Journal of Biomedical Optics, 23(8), 085005 (2018). link

S Tabassum, V Pera, G Greening, T Muldoon, Darren Roblyer, “Two-layer inverse model for improved longitudinal preclinical tumor imaging in the spatial frequency domain,” Journal of Biomedical Optics, 23(7), 076011 (2018). link

V Pera, K Karrobi, S Tabassum, F Teng, Darren Roblyer, “Optical property uncertainty estimates for spatial frequency domain imaging,” Biomedical Optics Express, 9(2), 661-678 (2018) link

M Applegate, Darren Roblyer, “Multi-distance diffuse optical spectroscopy with a single optode via hypotrochoidal scanning,” Optics Letters, 43(4), 747-750 (2018) link


H Peterson, B.H. Hong, D Geller, R Yang, R Gorlick, J Berger, J Tingling, M Roth, J Gill, Darren Roblyer, “In vivo, non-invasive functional measurements of bone sarcoma using diffuse optical spectroscopic imaging,” Journal of Biomedical Optics, 22(12), 121612 (2017) link

M Applegate, Darren Roblyer, “High-speed Spatial Frequency Domain Imaging (SFDI) with temporally modulated light,” Journal of Biomedical Optics, 22(7), 076019 (2017) link

A Leproux, TD. O’Sullivan, A Cerussi, Durkin A,Hill B, Hylton N, Yodh A, Carp S, Boas D, Jiang S, Pogue B, Darren Roblyer, Tromberg, B “Performance assessment of diffuse optical spectroscopic imaging instruments in a two-year, multicenter breast cancer trial,” Journal of Biomedical Optics, 22(12), 021604 (August 17, 2017) link

A. Torjesen, R Istfan, Darren Roblyer, “Ultrafast wavelength multiplexed broad bandwidth digital diffuse optical spectroscopy for in vivo extraction of tissue optical properties,” Journal of Biomedical Optics, 22(3), 036009 (2017) link

F Teng, T Cormier, A Sauer-Budge, R Chaudhury, V Pera, D Chargin, S Brookfield, N Yu Ko, Darren Roblyer, “Wearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions,” Journal of Biomedical Optics, 22(1), 014001 (Jan 13, 2017) link


S Tabassum, Y Zhao, R Istfan, J Wu, DJ Waxman, Darren Roblyer, “Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model,” Biomedical Optics Express 7(10), 4154-4170 (2016) link

B Tromberg, Z Zhang, A Leproux, TD. O’Sullivan, A Cerussi, P Carpenter, R Mehta, Darren Roblyer, W Yang , KD Paulsen, BW Pogue, S Jiang, P Kaufman, A Yodh, S Chung, M Schnall, B Snyder, N Hylton, D Boas, S Carp, S Isakoff, D Mankoff, “Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging (DOSI),” Cancer Research, 2016  link

Y Zhao, S Tabassum, S Piracha, M Sobhana Nandhu, M Viapiano, and Darren Roblyer,“Angle correction for small animal tumor imaging with spatial frequency domain imaging (SFDI),” Biomedical Optics Express 7(6), 2373-2384 (2016) link


P Diep, S Pannem, J Sweer, J Lo, M Snyder, G Stueber, Y Zhao, S Tabassum, R Istfan, J Wu, S Erramilli, Darren Roblyer, “Three-dimensional printed optical phantoms with customized absorption and scattering properties,” Biomedical Optics Express, 2015 Oct; 6(11) link

Y Zhao, Darren Roblyer, “Spatial mapping of fluorophore quantum yield in diffusive media,” Journal of Biomedical Optics, 2015 Aug; 20(8) 086013. link


J Jung, R Istfan, Darren Roblyer, “Note: A simple broad bandwidth undersampling frequency-domain digital diffuse optical spectroscopy system,” Review of Scientific Instruments, 2014 July; 85 link

R.P. Singh-Moon, Darren Roblyer, I.J. Bigio, S.Joshia, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency domain imaging,” Journal of Biomedical Optics, 2014 Aug; 19(9) link

G Greening, R Istfan, L Higgins, K Balachandran, Darren Roblyer, M Pierce, TJ Muldoon, “Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients in the visible to near-infrared domain,” Journal of Biomedical Optics, 2014 Sept; 19(11) 115002 link


Darren Roblyer, T O’Sullivan, R.V. Warren, BJ Tromberg, “Feasibility of direct digital sampling for disuse optical frequency domain spectroscopy in tissue,” Meas. Sci. Techn., 2013 March; 24(4) pdf

T O’Sullivan, A Leproux, J Chen, S Bahri, A Matlock, Darren Roblyer ,CE. McLaren, W Chen, A Cerussi, M Su, BJ Tromberg, “Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy,” Breast Cancer Research, 2013 Feb; 15


Darren Roblyer*, Ueda S*, Cerussi A, Durkin A, Leproux A, Santoro Y, Xu S, O’Sullivan T, Hsiang D, Mehta R, Butler J, Tromberg BJ. “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Research. , 2012 July; *shared first authorship pdf

A. Cerussi ,R. Warren, B. Hill, Darren Roblyer, A. Leproux, A.F. Durkin, T.D. O’Sullivan, S. Keene, H.Haghany, T.Quang, W.M. Mantulin, and B.J. Tromberg, “Tissue phantoms in multicenter clinical trials for diffuse optical technologies,”, Biomedical Optics Express, 2012 April; 3(5)


Darren Roblyer*, S. Ueda*, A. Cerussi, Tanamai W., A. Durkin, R. Metha, D. Hsiang, J. Butler, C.E. McLaren, W. Chen, B. Tromberg. “In Vivo Optical Imaging of Breast Cancer Oxyhemoglobin Flare Correlates with Neoadjuvant Chemotherapy Response One Day after Starting Treatment,” Proceedings of the National Academy of Sciences, United States of America. 108 (35). (2011 Aug) *shared first authorship pdf

T. Muldoon, Darren Roblyer, M.D. Williams, V.M. Stepanek, R. Richards-Kortum, A.M. Gillenwater. “Nonivasive imaging of oral neoplasia with a high-resolution fiber-optics microendoscope,” Head and Neck. (16). (2011 Mar) pdf


Darren Roblyer, C. Kurachi , V. Stepanek , R. Schwarz, M. Williams , A. El-Naggar , J. Jack Lee , A. Gillenwater, R. Richards-Kortum. “Comparison of Multispectral Widefield Optical Imaging Modalities to Maximize Image Contrast for Objective Discrimination of Oral Neoplasia,” Journal of Biomedical Optics. 15 (6). (2010 Nov-Dec) pdf

T. Muldoon , N.Thekkek , Darren Roblyer, D. Maru , N. Harpaz , J. Potack , S. Anandasabapathy , R. Richards-Kortum, “Evaluation of Quantitative Image Analysis Criteria for the High-Resolution Micro-Endoscopic Detection of Neoplasia in Barrett’s Esophagus,” Journal of Biomedical Optics, 2010 Mar-Apr;15(2).

Mohammed Rahman, N. Ingole, Darren Roblyer, V. Stepanek, R. Richards-Kortum, A.Gillenwater, S. Shastri, and P. Chaturvedi, “Evaluation of A Low-Cost, Portable Imaging System for Early Detection of Oral Cancer,” Head and Neck Oncology, 2010 Feb;2(10).


Darren Roblyer , C. Kurachi , V. Stepanek , M. Williams , A. El-Naggar , J. Jack Lee , A. Gillenwater, R. Richards-Kortum. “Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging,” Journal of Cancer Prevention Research. 2 (5): 423-31. (2009 May) pdf


Darren Roblyer, Sokolov KV, El-Naggar A, Williams M , Kurachi C , Gillenwater A, Rebecca Richards-Kortum. “A Multispectral Optical Imaging Device for In Vivo Detection of Oral Neoplasia,” Journal of Biomedical Optics. 13 (2). (2008 Mar-Apr) pdf

Javier, David*; Nitin, Nitin*; Darren Roblyer; Richards-Kortum, Rebecca, “Metal based nanorods as molecular specific contras agents for reflectance imaging in 3D tissues,” Nanophotonics. 2008 April;2


Darren Roblyer, Park SY, Richards-Kortum R, Adewole I, Follen M, “Objective Screening for Cervical Cancer in Developing Nations: Lessons from Nigeria,” Gynecologic Oncology. 2007 Oct;107(1 Suppl 1)

Nitin Nitin , David Javier , Darren Roblyer, Rebecca Richards-Kortum, “Widefield and High Resolution Reflectance Imaging of Gold and Silver Nanospheres,” Journal of Biomedical Optics. 2007 Sep-Oct;12(5)

Book Chapters:

J. Ferruzzi, Y. Zhang, Darren Roblyer and M. H. Zaman, “Chapter: Multi-scale Mechanics of Collagen Networks: Biomechanical Basis of Matrix Remodeling in Cancer”, Multi-scale Extracellular Matrix Mechanics and Mechanobiology, Yanhang Zhang (Editor), Springer Nature, 2019

M Wall, T Heaster, K Tilbury, WJ Choi, Darren Roblyer, R Wang, M Skala, J.T.C. Liu, “Chapter 5: Metabolic Imaging Approaches: Optical Imaging,” Imaging and Metabolism, Jason S. Lewis and Kayvan R. Keshari (Editors), Springer Nature, 2018

Darren Roblyer, R. Schwarz, R. Richards-Kortum, “Fluorescence Spectroscopy,” Handbook of Biomedical Optics, D. Boas, C. Pitris, N. Ramanujam (Editors), Taylor and Francis, 2011.

Darren Roblyer, A Cerussi, B.J.Tromberg, “Diffuse Optical Spectroscopic Imaging of Breast Cancer,” McGraw-Hill Series in Biophotonics, James Tunnel (Editor), McGraw-Hill, 2011.

Conference Articles:

S. Pannem, J. Sweer, P. Diep, J. Lo, M. Snyder, G. Stueber, Y. Zhao, S. Tabassum, R. Istfan, J. Wu, S. Erramilli, Darren M. Roblyer, “Customized three-dimensional printed optical phantoms with user defined absorption and scattering,” SPIE Photonics West, Proc. SPIE 9700, Design and Quality for Biomedical Technologies IX, 970008 (March 18, 2016)

F. Teng, T. Cormier, A. Sauer-Budge, Darren M. Roblyer, “A wearable optical device for continuous monitoring during neoadjuvant chemotherapy infusions,” SPIE Photonics West, Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150P (March 4, 2016)

J. Jung, R. Istfan, Darren Roblyer, “Effect of modulation frequency bandwidth on measurement accuracy and precision for digital Diffuse Optical Spectroscopy (DOS),” Proc. of SPIE 8936, Design and Quality for Biomedical Technologies VII, March 2014

Darren Roblyer , C. Kurachi , A. Gillenwater, R. Richards-Kortum, “In Vivo Fluorescence Hyperspectral Imaging of Oral Neoplasia,” Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, February 2009