Our collaborative projects focus on the analysis of protein-protein interactions (3 projects) and a variety of collaborations related to method development and applications of drug discovery, including protein drugs.
Analysis of ligand binding to DNA and RNA molecules
Vajda, Kozakov, and Frank-Kamenetskii groups Small molecules that bind to DNA are extremely useful as biochemical tools for the visualization of DNA both in vitro and inside the cell. Additionally, the clinical significance of DNA-binding compounds can hardly be overstated, as many anticancer regimens include a compound that binds to and/or... More
Targeting protein translation initiation for cancer therapy
Vajda, Porco, Kozakov, and Beglov groups, in collaboration with Jerry Pelletier (McGill University, Montreal) Supported by: NIH R01 GM064700 “Computational Mapping of Proteins for the Binding of Ligands” (PI: Vajda) Protein synthesis presents an emerging class of cancer drug targets. The translation process occurs in three phases: initiation, elongation, and termination, with initiation... More
The molecular origin of receptor-based developmental and reproductive toxicity
Vajda and Beglov groups, in collaboration with the Boston University Superfund Research Project Supported by: NIEHS P42ES007381 Receptor-Based Developmental And Reproductive Toxicity Of Superfund Chemicals (PI: D. Ozonoff) The Biomolecular Engineering Research Center is part of the Bioinformatics and Molecular Modeling Research Support Core, which offers computational tools, expertise, and services to a... More