Actively Recruiting Studies

Our Center supports a wide variety of Alzheimer’s disease-related research. If you are interested in participating in one of our studies, please call  (857)364-2140

or email for more information.

Although there may not be a study for you right now, there may be a study for you in the future.  Please still give us a call so we can keep you up to date on future studies.

Key: Mild Cognitive Impairment (MCI), Alzheimer’s Disease (AD)

Enrolling Studies 

Health Outreach Program for the Elderly (HOPE)

HOPE is a community-based resource that is intended for people with and without memory concerns. Participants will complete annual visits to assess their memory and other thinking skills. Following their visit, participants will receive feedback about their results and will have the opportunity to speak with a clinician. HOPE allows participants to play a more active role in their own healthcare. This study aims to collect a longitudinal set of data on a large, diverse group to advance our knowledge on the diagnosis, prevention, and treatment of Alzheimer’s disease and related disorders.

Locations in Boston and Needham

Eligibility: Healthy adults, MCI, AD who are 55 years and older.

Read More

HOPE Study Seeking Contact Sport Athletes – Both Men & Women

We are also recruiting participants with a history of contact sports to help us understand how repetitive head impacts affect a person’s risk of developing later-life neurologic disorders.

Read More

Cerebral Perfusion and Metabolism in Chronic Traumatic Encephalopathy

This study aims to compare Alzheimer’s disease and Chronic Traumatic Encephalopathy. Alzheimer’s disease participants will undergo a one-hour MRI. Participants should have little to no history of head injury and should have no history of playing contact sports.  Located in Boston.

Eligibility: Diagnosed with AD between the ages of 45-74.

Digital Technology Study

This study is looking at the feasibility of using wearable technology to detect differences between cognitively normal, mild cognitively impaired, and Alzheimer’s disease participants of the HOPE study. The devices will be used in combination with smartphone applications to gather lifestyle data on participants, which will contribute to the understanding of indicators of cognitive impairment and Alzheimer’s disease.  Located in Boston.

Eligibility: Healthy Adults, MCI, AD and are between the ages of 65-95.

(Need to go through HOPE assessment)

Digital Phenotyping

The purpose of the study is to better understand Alzheimer’s disease and dementia through the use of technology like smartphone applications or wearable devices. 

(Need to go through HOPE assessment)

Eye to Brain (Tears and cognition) 

This study aims to identify proteins in the eye that could be related to brain function and diseases like Alzheimer’s.

Eligibility: Healthy Adults with a family history, and are between the ages of 65 – 80.

(Need to go through HOPE assessment)

Amylin Diagnostic 

This study is testing whether it is possible to repurpose a diabetes drug called pramlintide as a diagnostic test for Alzheimer’s disease. Participants will undergo a PET scan, two infusions, and several blood tests over the course of three total visits. Located in Boston.

Eligibility: Healthy Adults, MCI, AD, and are between the ages 60 – 90

(Need to go through HOPE assessment)

Multi-center Development of a Novel Diagnostic Test for Alzheimer’s Disease (DTAD)

Currently, there are no blood tests used to diagnose AD, nor any screening tests for the prodromal stage of AD. The aim of this study is to develop a simple blood test, using an FDA-approved diabetic drug, to diagnose AD. Located in Boston.

Eligibility: Healthy Adults, Amnestic MCI, Probable AD, and are between the ages 60 – 90

(Need to go through HOPE assessment)

AHEAD 3-45 

This study is a four-year clinical trial evaluating an investigational treatment to slow the earliest brain changes and help prevent symptoms associated with Alzheimer’s disease.  The AHEAD 3-45 Study requires a number of medical procedures that will be performed at no cost to participants. Please note this is not an approved treatment but is under investigation.  Located in Boston.

Eligibility: Healthy Adults, who are not at risk of developing AD and/or do not have symptoms of AD. Age 55 – 80. 

AHEAD Study – Read More Here

Understanding the lived experiences of couples across the trajectory of dementia 

This study seeking older couples to participate in a study of long-term relationships. NYU Langone Health and Boston University School of Medicine are conducting a study to understand how different ways in which older adults interact with their partners may impact the well-being of couples as they age. If you are over 65 and a member of a couple, you may be eligible to participate. Located in the Boston area and New York City. 

Eligibility: You and your partner are over 65 years old and live at home together. You and your partner are comfortable speaking Elgish. Your partner agrees to participate. 

If you are interested in learning more about this study, contact: Andrew Nguyen at 617-358-6437 or email at

Study Flyer

Studies On Hold Due To COVID-19 

Alzheimer’s Disease Neuroimaging Initiative 3

A longitudinal study designed to investigate the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer’s disease. Located in Boston.

Eligibility: Healthy adult or diagnosed with MCI or AD between the ages of 55-90.


The REVEAL-SCAN research study conducted at Brigham and Women’s Hospital is exploring the impact of learning amyloid imaging results, and how to safely communicate these results and educate on the risk of developing Alzheimer’s disease.

Eligibility: Healthy Adult between the ages of 65-80 with a family history.

Chronic Stress and Aging Research Study

 A larger percentage of African Americans than Americans of European ancestry have Alzheimer’s disease. The underlying causes of this health disparity are not well understood. Discrimination related to racial minority status is a salient chronic psychosocial stressor in African Americans and has negative health consequences. This suggests that psychosocial chronic stress due to experiences of racism may contribute to the health disparity in Alzheimer’s disease. 

We will examine whether measures of psychological stress are correlated with cognitive performance assessed with a telephone cognitive assessment tool and subjective memory concerns. We will also examine whether physical health, assessed via cardiovascular risk factors (which are also risk factors for Alzheimer’s disease), is related to chronic stress. Located in Boston.

Eligibility: Between the ages of 60 and 80 years; Identify as Black/African American or White/European American

Live in the Greater Boston area and you generally available for the duration of the study