Gyungah Jun

Co-Leader Genetics and Molecular Profiling Core

Ph.D. Epidemiology and Biostatistics, School of Medicine,
Research Interests

Dr. Jun has worked in a broad spectrum of medical fields including wet-lab-based research including purification and characterization of a B-lymphocyte inducing factor (BIF) using single-cell cloning of human myeloma cell line and mouse models and establishment of human neuronal cell lines, and dry-lab (computational) researches including the development of DNA pattern recognition program, investigation of loci involved in the progression of type 2 diabetes, genome-wide linkage and association analyses for druse formation, age-related macular degeneration, cataract, and diabetic nephropathy using worldwide longitudinal cohorts, and identification of causal variants in an axon guidance molecule for age-related cortical cataract using targeted sequencing projects. She has also been involved in large genetics consortiums for diabetic nephropathy, age-related macular degeneration, age-related cataract, and Alzheimer’s disease. In these collaborative efforts, much of her work is engaged in study design, development of analysis plan, database development and management, implementation of statistical methods, and translational study design for drug discovery.

Her current projects encompass multidisciplinary areas: (1) identify early biomarkers for Alzheimer’s disease in the lens by identifying shared genetic markers for eye and brain-related neurodegenerative phenotypes using sequencing and genome-wide linkage and association studies, (2) screen potential drug targets and risk screening tools for Alzheimer disease by investigating the genetic architecture of DNA and mRNA from genes in axon guidance molecules, (3) discover causal mutations for idiopathic membranous nephropathy by sequencing candidate genes from multiethnic groups of subjects, (4) develop novel analytical and bioinformatics tools for bivariate framework on gene-gene and gene-environment interaction analyses, and (5) lead statistical analysis groups for international and nation-wide consortia for Alzheimer disease and eye diseases using genome-wide association data, whole exome, and whole genome sequencing projects.

 Jun Lab 


Selected Publications

Jun G, Song Y, Stein CM, and Iyengar SK. 2003. An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression. BMC Genetics 4(S1/S8): 1 – 7. PMID: 14975076.

Jun G, Guo H, Klein BE, Klein R, Wang JJ, Mitchell P, Miao H, Lee KE, Joshi T, Buck M, Chugha P, Bardenstein D, Klein AP, Bailey-Wilson JE, Gong X, Spector TD, Andrew T, Hammond CJ, Elston RC, Iyengar SK, Wang B. 2009. EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet Jul;5(7):e1000584. Epub 2009 Jul 31. PMID: 19649315.

Jun G, Naj AC, Beecham GW, Wang L-S, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin D, Friedland R, Inzelberg R, Kramer P, Rogaeva E, George-Hyslop PG, ADGC, Cantwell L, Dombrosk BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples AL, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Petricak-Vance MA, Schellenberg GD. 2010. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer’s disease risk loci and reveals interactions with APOE genotypes. Arch Neurol Dec;67(12):1473-84. PMID: 20697030.

Naj AC, Jun G, Beecham GW, Wang L-S, Buros J, Vardarajan BN, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PD, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JSK, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, George-Hyslop PS, Alzheimer Disease Genetics Consortium, Cantwell RB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh ML, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. 2011. Common variants in MS4A4/MS4A6ECD2APCD33, and EPHA1 are associated with late-onset Alzheimer’s disease. Nat Genet May;43(5):436-41. PMID: 21460841.

Jun G, Nicolaou M, Morrison MA, Buros J, Morgan DJ, Radeke MJ, Yonekawa Y, Tsironi EE, Kotoula MG, Zacharaki F, Mollema N, Yuan Y, Miller JW, Haider NB, Hageman GS, Kim IK, Schaumberg DA, Farrer LA, Deangelis MM. 2011. Influence of ROBO1 and RORA on Risk of Age-related Macular Degeneration Reveals Genetically Distinct Phenotypes in Disease Pathophysiology. PLoS One. 2011;6(10):e25775. Epub 2011 Oct 6. PMID: 21998696.

Choi SH, Liu C, Dupuis J, Logue MW, Jun G. 2011. Using linkage analysis of large pedigrees to guide association analysis. BMC Proc 2011 Nov 29;5 Suppl 9:S79. PMID: 22373287.

Jun G, Vardarajan BN, Buros J, Yu C-E, Hawk M, Dombrowski B, Crane PK, Larson E, ADGC, Mayeux R, Haines J, Lunetta KL, Pericak-Vance MA, Schellenberg GD, Farrer LA. 2012. A comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol. 2012 Aug 6:1-10. doi: 10.1001/archneurol.2012.2052. PMID: 22869155.

Kamboh MI, Demirci FY, Wang X, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ, Jun G, Baldwin C, Logue MW, Buros J, Farrer L, Pericak-Vance MA, Haines JL, Sweet RA, Ganguli M, Feingold E, Dekosky ST, Lopez OL, Barmada MM (2012) Genome-wide association study of Alzheimer’s disease. Transl Psychiatry. 2012 May 15;2:e117. doi: 10.1038/tp.2012.45. PMID: 22832961.

Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, George-Hyslop P, Goldstein LE, Farrer LA#. 2012. δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS One. 2012;7(9):e43728. Epub 2012 Sep 11. PMID: 22984439.


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