News
Dr. Sarah Davies Featured in The Brink
Dr. Sarah Davies was recently featured in The Brink's article, "Sexism and Racism in Science: How the Coronavirus Pandemic Exposed Everything." The Brink interviewed Dr. Davies about her new PLOS Biology paper, "Promoting inclusive metrics of success and impact to dismantle a discriminatory reward system in science." The paper is the product of a collaboration between Dr. Davies and 23 others, including BU's Dr. Wally Fulweiler, Dr. Colleen Bove, and Dr. Hanny Rivera. An excerpt of The Brink article is below:
In science, career progress—or lack thereof—is typically determined by certain criteria, such as how often a researcher’s studies are cited by other scientists, and by the number of papers they publish in prestigious, high-impact scientific journals (which often comes with an expensive price tag paid by a paper’s authors). Those metrics, however, are biased against already marginalized groups in science—namely, those who don’t identify as white males—and ensure that sexism and racism continue to plague the field, according to 24 researchers who have penned a new PLOS Biology piece on the topic.
Sarah Davies, the piece’s co-lead author and a Boston University College of Arts & Sciences assistant professor of biology, says the time crunch and workload created by the coronavirus pandemic was a tipping point for many marginalized researchers. “I’ve never been busier, so it was an interesting choice to take on a ‘perspectives’ piece outside my field of [marine biology] research,” she says. “But the coronavirus pandemic created the perfect storm of being ‘over it.’” For Davies, that meant the daunting task of navigating a changing work and research environment while juggling childcare amidst the pandemic.
Read the full article here.
Amanda Pinheiro Recipient of 2021 Kilachand Fellowship
Amanda Pinheiro of the Naya Lab is a recipient of a 2021 Kilachand Fellowship. This fellowship is funded by the Biological Design Center's Multicellular Design Program (MDP), which combines research in Synthetic Biology, Microbial Engineering, Tissue Engineering, Data Science, and Biophysics to understand the design principles of multicellular systems. Amanda will be working on a project entitled “Elucidating Complex Cell-Cell Interactions in the Regenerative Skeletal Muscle Microenvironment.”
Congratulations, Amanda!
Margaret O’Connor Receives Brenton R. Lutz Award
Margaret O'Connor of the Man Lab, is the recipient of this year’s Biology Department Brenton R. Lutz Award. Margaret is investigating the X-linked protein NEXMIF, which is associated with Autism Spectrum Disorder (ASD). She uses a transgenic mouse model to study the role NEXMIF plays in brain development, specifically neuronal growth and dendritic spine development. There are a number of human patients with NEXMIF dependent ASD. Her research currently focuses on the unique situation of female heterozygotes which mosaically express NEXMIF yet still develop ASD.
This award provides support for PhD candidates conducting research in neurobiology or neuroscience and have made significant contributions to their field. Brenton R. Lutz was the first person to receive an MD/PhD at Boston University, receiving his PhD in 1916. He later became a Professor and Chairman of BU’s Department of Biology. Dr. Lutz also gave the first University Lecture at BU on December 11, 1950 “The Living Blood Vessels.”
Congratulations, Margaret!
Michael Zulch Interning at Joyn Bio
Michael Zulch of the Larkin Lab was selected for a summer internship with Joyn Bio as part of the Training Program in Synthetic Biology & Biotechnology (SB2). Joyn Bio is a joint venture between Ginkgo Bioworks and Leaps by Bayer, founded to solve the urgent agriculture challenges threatening our global food supply and environmental health using the combination of synthetic biology and beneficial microbes.
Joyn Bio aims to provide growers with new and sustainable solutions to feed and nourish the world. Michael will be working on their primary project: engineering crop-colonizing microbes that can fix atmospheric nitrogen into a form that plants can use to grow. If successful, these bacteria will help alleviate our dependence on synthetic fertilizers and their environmental impacts.
Congratulations, Michael!
Sarah Davies Receives NSF Awards
Dr. Sarah Davies recently received two National Science Foundation (NSF) awards: a Biological Oceanography award and a co-funded Biological Oceanography and Biological Sciences award.
Dr. Davies is collaborating with Dr. Kirstin Meyer-Kaiser at WHOI for the NSF Biological Oceanography award, which will fund the proposal "Collaborative Research: How do selection, plasticity, and dispersal interact to determine coral success in warmer and more variable environments?". Dr. Davies and Dr. Meyer-Kaiser will conduct coral spawning research in the Rock Islands in Palau alongside Palauan interns in spring 2022. This work will also fund a Reef Music event in collaboration with Multiverse. The event will be conducted in Spanish and will be free of charge to attendees in East Boston. Dr. Davies is the PI and Dr. Meyer-Kaiser is the co-PI.
Dr. Davies is collaborating with with Dr. Adrienne Correa at Rice University and Dr. John Parkinson at University of Southern Florida for the co-funded NSF Biological Oceanography and Biological Sciences award, which will fund the proposal "Collaborative Research: Building consensus around the quantification and interpretation of Symbiodiniaceae diversity." The overarching goal of this workshop is to recognize and build further consensus around the identification and analysis of Symbiodiniaceae (the coral's algal symbiont) genetic variation and come up with a practical ‘consensus road map’. This workshop will take place via Zoom, with 75 researchers from across the world attending. Dr. Davies is the PI and Dr. Correa and Dr. Parkinson are the co-PIs.
Research in the Davies Lab leverages in situ environmental data and mesocosm/culturing work with large-scale genomic and transcriptomic data to identify the mechanisms underlying adaptation, dispersal, and symbiosis in corals. The lab's long-term research vision aims to uncover mechanistic links from phenotype to genotype and predict evolutionary trajectories for this critical symbiosis under climate change.
Congratulations, Sarah!
Clarissa Santoso publishes paper in Nucleic Acids Research
MCBB PhD student Clarissa Santoso, of the Fuxman Bass lab, and colleagues recently published a paper in Nucleic Acids Research. Their article, “Comprehensive mapping of the human cytokine gene regulatory network”, presents a large-scale resource of protein-DNA interactions between transcription factors and cytokine gene promoters. In particular, Clarissa and her team identified an enrichment of nuclear receptors which can be targeted with small molecules to modulate cytokine expression in the context of disease. This resource can also be leveraged to identify novel TF-cytokine regulatory axes in immune diseases and immune cell lineage development, as nicely illustrated in their paper. Read the paper here. Congratulations, Clarissa!Dr. Kim McCall Featured in The Brink
They’re the bane of summer picnics, the nemesis of busy kitchens. For most of us, flies are a seasonal annoyance, buzzing pests to be shooed, sprayed, or swatted. But to scientists, the insects are the ideal test subjects for studying a range of human diseases. What’s happening at the molecular level in their tiny bodies as they grow, age, and get sick closely mirrors what happens in ours—about 70 percent of human disease genes can also be found in flies. But they’re much less complex creatures, making it easier for researchers like Kim McCall to uncover valuable new insights into a host of chronic diseases.
McCall’s lab at Boston University is full of fruit flies. Tens of thousands of them, known as Drosophila melanogaster, are stored carefully in vials in a temperature-controlled room. McCall, a BU College of Arts & Sciences professor and chair of biology, studies Drosophila to better understand the molecular mechanisms that cause programmed cell death, particularly in the ovaries and brain. Cell death is a vital part of life in all animals, including flies and humans. It’s what enabled your body to develop in the womb—old cells making way for new ones—and what gives you a fighting chance against viruses as your body takes down infected cells. But it doesn’t always go according to plan.
Read the full Brink article here.
Dr. Muhammad Zaman Publishes New Book, Biography of Resistance
For the past eight months, the world’s attention has been focused on the deadly health crisis caused by the COVID-19 pandemic, which has already infected 30 million people and killed more than 950,000.
But in his gripping, highly readable new book, Biography of Resistance: The Epic Battle Between People and Pathogens (Harper Wave, 2020), Muhammad Zaman, a Boston University College of Engineering professor of biomedical engineering and of materials science and engineering, says there is an equally urgent crisis before us—drug-resistant infections.
More than 700,000 people die each year as a result of multidrug-resistant diseases, including at least 35,000 in the United States. And as Zaman, a Howard Hughes Medical Institute Professor, makes clear, the situation is getting more urgent. Without action, he writes, we are likely to face an unimaginable public health crisis: “It will be like the great plague of the Middle Ages, the influenza pandemic of 1918, the AIDS crisis of the 1990s, and the Ebola epidemic of 2014 all combined into a single threat.” A 2019 report issued by the United Nations Ad Hoc Interagency Coordination Group on Antimicrobial Resistance predicts that drug-resistant diseases could claim as many as 10 million lives a year by 2050.
Read the full article on BU Today.
Dr. Joseph Larkin Receives Innovation Career Development Professorship
Dr. Joseph Larkin received this year’s Innovation Career Development Professorship, which recognizes junior faculty whose translational research is likely to lead to future licensed technology.
Dr. Larkin’s interdisciplinary work examines how the physical and chemical environment influences microbes (in particular, bacterial biofilms), and how those microbes, in turn, engineer that environment through extracellular matrix and cell-to-cell signals to perpetuate and evolve. His research holds important practical implications for, among other things, maintaining the safety and sanitation of medical devices and water lines.
Dr. Douglas Densmore Awarded NSF Grant
Dr. Douglas Densmore and Dr. Rabia Yazicigil were awarded a $1.5M grant by the National Science Foundation for project entitled “SemiSynBio-II: Hybrid Bio-Electronic Microfluidic Memory Arrays for Large Scale Testing and Remote Deployment.” Professor Ahmad Khalil and Professor Wilson Wong of BME are also Co-PIs on the grant.
The award is for a three-year project aiming to leverage the memory of complex genetic systems in order to create smart biosensors. Bacteria or mamalia cells, living systems, will be able to “remember” things they have seen in their environment. Using these engineered cellular memory elements, Densmore and his team will create smart biosensors. By creating artificial environments using microfluidic devices, the team will then generate custom biological memory elements for those devices. The devices will be equipped with electronic technology that can detect and respond to biological changes. When these devices are in “swarms,” they can collectively act as smart biosensors in the environment.
Read the full announcement here.