Computational Imaging

Computational Imaging jointly designs optics and algorithms. This field of research is inherently interdisciplinary, combining expertise in imaging science, optical engineering, signal processing and machine learning. Computational imaging can overcome physical limitations and achieve novel capabilities, from advancing experimental observation techniques used in biology, to highly novel imaging system methods to atomic force microscopy. Computational Imaging serves a broad range of scientific, defense and security, biomedical, and neuroscience applications.

Efficient Two-Photon Voltage Imaging of Neuronal Populations at Behavioral Timescales

Understanding how information is processed in the mammalian neocortex has been a longstanding question in neuroscience. While the action potential is the fundamental bit of information, how these spikes encode representations and drive behavior remains unclear. In order to adequately address this problem, it has become apparent that experiments are needed in which activity from […]

Professor Tian’s Paper on Adaptive 3D Descattering is the Cover Feature in Nature’s Light: Science & Applications

CISE faculty affiliate Lei Tian (ECE, BME) has published a paper entitled Adaptive 3D descattering with a dynamic synthesis network that was featured on the cover of Nature’s Light: Science & Applications.  Tian’s paper focused on training a descattering network for image recovery in scattering media using an adaptive learning framework, termed dynamic synthesis network (DSN). The framework […]

Computational Miniature Mesoscope for Cortex-wide, Cellular resolution Ca2+ Imaging in Freely Behaving Mice

Scale is a fundamental obstacle in linking neural activity to behavior. While perception and cognition arise from interactions between diverse brain areas separated by long distances, neural codes and computations are implemented at the scale of individual neurons. An integrative understanding of brain dynamics thus requires cellular-resolution measurements across sensory, motor, and executive areas spanning […]

Lighting the Way Forward for Autonomous Vehicles

CISE Faculty Affiliate Ajay Joshi with collaborators at Lightmatter and Harvard University receive $4.8M IARPA grant to develop a new Electro-Photonic Computing (EPiC) system for  AI-based navigation in Autonomous Vehicles Anyone who has ever been behind the wheel of a car knows that response time is crucial. The human sensory system needs to be fully engaged in order […]

Reflection-mode Computational 3D Phase and Polarization Imaging for Semiconductor Wafer Metrology and Inspection

The goal of this project is to prototype a reflection-mode computational microscope to 1) provide wide field-of-view (FOV) and high-resolution phase reconstruction using a new reflection-mode Fourier ptychography (FP) algorithm; 2) enable 3D phase reconstruction based on a new reflection-mode multi-slice beam-propagation method (MS-BPM) model; and 3) investigate the utility of polarization sensitive contrast in […]

Stealth Driverless Cars without Visible Light?

CISE Faculty Affiliate Professor Vivek Goyal (ECE) recently received a Defense Advanced Research Projects Agency (DARPA) subaward for his work in connection with the agency’s Invisible Headlights program. Professor Goyal is working under an award to MIT entitled, Super Headlights: Superconducting Nanowire Detectors for Passive Infrared Sensing.  The DARPA Invisible Headlights program has a very […]