Research Publications
CELL-MET faculty, trainees, and staff have published over 100 articles. Where available, publicly accessible links are provided below.
October 2022 to September 2023: Project Year 6
Ronaldson-Bouchard, K., Teles, D., Yeager, K., Tavakol, D.N., Zhao, Y., Chramiec, A., Tagore, S., Summers, M., Stylianos, S., Tamargo, M. and Lee, B.M., 2022. A multi-organ chip with matured tissue niches linked by vascular flow. Nature Biomedical Engineering, 6(4), pp
Integrated Engineering Goal 2
Baker, B. M., Bluem, A. S., DePalma, S., Jewett, M., Stis, A., & Xi, S. (2022). Microfabricated Anisotropic Tissue Bundles for the Production of 3D Cardiac Tissue at Scale. Circulation, 146(Suppl_1), A15845-A15845.
Jewett, M. E., Bluem, A. S., Xi, S. S., Zhang, Z., Hiraki, H. L., Wojasiński, M., & Baker, B. M. (2023). Rapid Magnetically Directed Assembly of Pre‐Patterned Capillary‐Scale Microvessels. Advanced Functional Materials, 2203715.
Jewett, M., Bluem, A., Xi, S., DePalma, S., Stis, A., & Baker, B. (2022). Microfabricated Anisotropic Tissue Bundles for the Production of 3D Cardiac Tissue at Scale. Circulation, 146(Suppl_1), A15845-A15845.
Integrated Engineering Goal 3
Lou, L., Paolino, L., & Agarwal, A. (2023). Bridging the Gap in Ashby’s Map for Soft Material Properties for Tissue Engineering. ACS Applied Materials & Interfaces.
Mohammadzadeh, S., & Lejeune, E. (2023). SarcGraph: A Python package for analyzing the contractile behavior of pluripotent stem cell-derived cardiomyocytes. Journal of Open Source Software, 8(85), 5322.
Reichart, D., Lindberg, E. L., Maatz, H., Miranda, A. M., Viveiros, A., Shvetsov, N., … & Seidman, C. E. (2022). Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science, 377(6606), eabo1984.
Intergraded Engineering Goal 1 & 3
Lou, L., Agarwal, A., He, J., & Rubfiaro, A. S. (2023). Understanding Spatiotemporal Mechanical Behavior, Viscoelasticity, and Functions of Stem Cell-Derived Cardiomyocytes. Nanoscale.
Ma, M. S., Bifano, T. G., Agarwal, A., Chen, C. S., Lou, L., & Sundaram, S. (2023). High throughput screening system for engineered cardiac tissues. Frontiers in Bioengineering and Biotechnology, 11, 1177688.
Thrust 1
Lenzi, E., Jimenez de Aberasturi, D., Henriksen-Lacey, M., Piñeiro, P., Muniz, A.J., Lahann, J. and Liz-Marzán, L.M., 2022. SERS and Fluorescence-Active Multimodal Tessellated Scaffolds for Three-Dimensional Bioimaging. ACS applied materials & interfaces.
Thrust 3
Margara, F., Psaras, Y., Wang, Z. J., Schmid, M., Doste, R., Garfinkel, A. C., … & Bueno-Orovio, A. (2022). Mechanism based therapies enable ersonalized treatment of hypertrophic cardiomyopathy. Scientific Reports, 12(1), 22501.
Margara, F., Psaras, Y., Wang, Z.J., Schmid, M., Doste, R., Garfinkel, A., Repetti, G.G., Seidman, J., Seidman, C., Rodriguez, B. and Toepfer, C.N., 2022. Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy. bioRxiv.
Thrust 4
Haber, A. and Bifano, T. (2022). Dual-update data-driven control of deformable mirrors using Walsh basis functions. JOSA A, 39(3), pp.459-469.
Moore, J., Ewoldt, J., Venturini, G., Pereira, A. C., Padilha, K., Lawton, M., … & Emili, A. (2023). Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation–Contraction Coupling. International journal of molecular sciences, 24(5), 4724.
Thrust 2 & Testbeds
Agarwal, A., John, D., Lou, L., Rodrigues de Oliveira, N., Sahani, R., & Sukumaran, A. K. (2023). Localized Nanoindentation Paradigm for Revealing Sutured Tissue Interface Mechanics and Integrity. ACS Applied Bio Materials, 6(2), 908-918.
Nautiyal, P., Agarwal, A., Bacca, N., Thomas, T., Wiedorn, V., & White, A. (2022). Unraveling the Mechanisms Governing Anisotropy in Accordion‐Shaped Honeycomb Microlattice Fabricated by Two‐Photon Polymerization. Advanced Engineering Materials, 24(5), 2101190.
Thrust 2, 4 & Testbeds
Imboden, M., Chen, S., Gudozhnik, O., Pollock, C., Javor, J., Bishop, D., … & Rosset, S. (2022). The integration of optical stimulation in a mechanically dynamic cell culture substrate. Frontiers in Bioengineering and Biotechnology, 10, 934756.
Thrust 1, 2, 4, Testbeds & Innovation Ecosystem
Javor, J., Imboden, M., Stange, A., Yao, Z., Campbell, D.K. and Bishop, D.J. (2022). Zeptometer Metrology Using the Casimir Effect. Journal of Low Temperature Physics, pp.1-13.
Thrust 4, Testbeds & Innovation Ecosystem
Javor, J., Yao, Z., Barrett, L., Imboden, M., Apte, S., Giannetta, R. W., … & Bishop, D. J. (2023). Modal engineering of electromagnetic circuits to achieve rapid settling times. Review of Scientific Instruments, 94(1), 014708.
Workforce Development Education & Inclusion
Kalkunte, N., McGowen, L., Qasim, M., & Borrego, M. (2022, August). Conducting a Diversity, Equity, and Inclusion Climate Survey of Engineering within a Large Texas University. In 2022 ASEE Annual Conference & Exposition.
October 2021 to September 2022: Project Year 5
Ahrens, J., Uzel, S., Skylar‐Scott, M., Mata, M., Lu, A., Kroll, K. and Lewis, J.A., 2022. Programming Cellular Alignment in Engineered Cardiac Tissue via Bioprinting Anisotropic Organ Building Blocks. Advanced Materials, p.2200217. DOI: https://doi.org/10.1002/adma.202200217
Bifano, T., Chen, C., Li, H., Sundaram, S. and Hu, R., 2021. Dynamic Control of Contractile Force in Engineered Heart Tissue. DOI: https://doi.org/10.36227/techrxiv.15025236.v1
Davidson, C.D., DePalma, S.J., Wang, W.Y., Kamen, J.L., Jayco, D.K.P. and Baker, B.M., 2021. Mechanical intercellular communication via matrix-borne cell force transmission during vascular network formation. bioRxiv. DOI: https://doi.org/10.1101/2021.08.17.456669
Javor, J., Imboden, M., Stange, A., Yao, Z., Campbell, D.K. and Bishop, D.J., 2022. Zeptometer Metrology Using the Casimir Effect. Journal of Low Temperature Physics, pp.1-13. DOI: https://doi.org/10.1007/s10909-021-02650-3
Haber, A. and Bifano, T., 2021. General approach to precise deformable mirror control. Optics Express, 29(21), pp.33741-33759. DOI: https://doi.org/10.1364/OE.439306
Lock, R., Al Asafen, H., Fleischer, S., Tamargo, M., Zhao, Y., Radisic, M. and Vunjak-Novakovic, G., 2021. A framework for developing sex-specific engineered heart models. Nature Reviews Materials, pp.1-19. DOI: https://doi.org/10.1038/s41578-021-00381-1
Lou, L., Lopez, K.O., Nautiyal, P. and Agarwal, A., 2021. Integrated Perspective of Scaffold Designing and Multiscale Mechanics in Cardiac Bioengineering. Advanced NanoBiomed Research, p.2100075. DOI: https://doi.org/10.1002/anbr.202100075
Nautiyal, P., Wiedorn, V., Thomas, T., Bacca, N., White, A. and Agarwal, A., Unraveling Mechanisms Governing Anisotropy in Accordion‐shaped Honeycomb Microlattice Fabricated by Two‐Photon Polymerization. Advanced Engineering Materials. DOI: https://doi.org/10.1002/adem.202101190
Pandey, P., Rubfiaro, A.S., Khatri, S. and He, J., 2021. Development of multifunctional nanopipettes for controlled intracellular delivery and single-entity detection. Faraday Discussions. DOI: https://doi.org/10.1039/D1FD00057H
Rodríguez, C., Chen, A., Rivera, J.A., Mohr, M.A., Liang, Y., Natan, R.G., Sun, W., Milkie, D.E., Bifano, T.G., Chen, X. and Ji, N., 2021. An adaptive optics module for deep tissue multiphoton imaging in vivo. Nature Methods, 18(10), pp.1259-1264. DOI: https://doi.org/10.1038/s41592-021-01279-0
Tsan, Y.C., DePalma, S.J., Zhao, Y.T., Capilnasiu, A., Wu, Y.W., Elder, B., Panse, I., Ufford, K., Matera, D.L., Friedline, S. and O’Leary, T.S., 2021. Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform. Nature Communications, 12(1), pp.1-16. DOI: https://doi.org/10.1038/s41467-021-26496-1
Zhang, K., Cloonan, P.E., Sundaram, S., Liu, F., Das, S.L., Ewoldt, J.K., Bays, J.L., Tomp, S., Toepfer, C.N., Marsiglia, J.D. and Gorham, J., 2021. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Science advances, 7(42), p.eabh3995. DOI: https://doi.org/10.1126/sciadv.abh3995
Zhao, B., Zhang, K., Chen, C.S. and Lejeune, E., 2021. Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes. arXiv preprint arXiv:2102.02412. DOI: https://doi.org/10.1371/journal.pcbi.1009443
October 2020 to September 2021: Project Year 4
Agarwal, R., Paulo, J.A., Toepfer, C.N., Ewoldt, J.K., Sundaram, S., Chopra, A., Zhang, Q., Gorham, J., DePalma, S.R., Chen, C.S. and Gygi, S.P., 2021. Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation. Circulation Research, 129(7), pp.751-766. DOI: https://doi.org/10.1161/CIRCRESAHA.120.317076
Barrett, L. K., Imboden, M., Javor, J., Campbell, D. K., & Bishop, D. J. (2021). Feedforward Control Algorithms for MEMS Galvos and Scanners. Journal of Microelectromechanical Systems. DOI: https://doi.org/10.1109/JMEMS.2021.3074301
Barrett, L.K., Lally, R.W., Fuhr, N.E., Stange, A. and Bishop, D.J., 2020. A Chip-Scale, Low Cost PVD System. Journal of Microelectromechanical Systems, 29(6), pp.1547-1555. DOI: https://doi.org/10.1109/JMEMS.2020.3026533
Chramiec, A., Teles, D., Yeager, K., Marturano-Kruik, A., Pak, J., Chen, T., Hao, L., Wang, M., Lock, R., Tavakol, D. N., Lee, M. B., Kim, J., Ronaldson-Bouchard, K., and Vunjak-Novakovic, G., 2020. Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety. Lab on a chip, 20(23), 4357–4372. DOI: https://doi.org/10.1039/d0lc00424c
DePalma, S.J., Davidson, C.D., Stis, A.E., Helms, A.S. and Baker, B.M., 2021. Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices. Biomaterials Science, 9, pp.93-107. DOI: https://doi.org/10.1039/D0BM01247E
Guo, J., Yan, X., Xu, M., Ghimire, G., Pan, X., & He, J. (2021). Effective Electrochemical Modulation of SERS Intensity Assisted by Core–Shell Nanoparticles. Analytical Chemistry, 93(10), 4441-4448. DOI: https://doi.org/10.1021/acs.analchem.0c04398
Horowitz, J. A., Zhong, X., DePalma, S. J., Ward Rashidi, M. R., Baker, B. M., Lahann, J., & Forrest, S. R. (2021). Printable Organic Electronic Materials for Precisely Positioned Cell Attachment. Langmuir, 37(5), 1874-1881. DOI: https://doi.org/10.1021/acs.langmuir.0c03319
Javor, J., Sundaram, S., Chen, C.S. and Bishop, D.J., 2020. A microtissue platform to simultaneously actuate and detect mechanical forces via non-contact magnetic approach. Journal of Microelectromechanical Systems, 30(1), pp.96-104. DOI: https://doi.org/10.1109/JMEMS.2020.3036978
Javor J, Ewoldt JK, Cloonan PE, Chopra A, Luu RJ, Freychet G, Zhernenkov M, Ludwig K, Seidman JG, Seidman CE and Chen CS., 2021, January. Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue. DOI: https://doi.org/10.1038/s41378-020-00234-x
Javor, J., Sundaram, S., Chen, C. and Bishop, D.J., 2020, January. Controlled strain of cardiac microtissue via magnetic actuation. In 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 452-455). IEEE. DOI: https://doi.org/10.1109/MEMS46641.2020.9056152
Javor, J., Stange, A., Pollock, C., Fuhr, N. and Bishop, D.J., 2020. 100 pT/cm single-point MEMS magnetic gradiometer from a commercial accelerometer. Microsystems & nanoengineering, 6(1), pp.1-13. DOI: https://doi.org/10.1038/s41378-020-0173-z
Javor, J., Yao, Z., Imboden, M., Campbell, D.K. and Bishop, D.J., 2021. Analysis of a Casimir-driven parametric amplifier with resilience to Casimir pull-in for MEMS single-point magnetic gradiometry. Microsystems & nanoengineering, 7(1), pp.1-11. DOI: https://doi.org/10.1038/s41378-021-00289-4
Jayne, R.K., Karakan, M.Ç., Zhang, K., Pierce, N., Michas, C., Bishop, D.J., Chen, C.S., Ekinci, K.L. and White, A.E., 2021. Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers. Lab on a Chip, 21(9), pp.1724-1737. DOI: https://doi.org/10.1039/D0LC01078B
Kong, N., Guo, J., Chang, S., Pan, J., Wang, J., Zhou, J., Liu, J., Zhou, H., Pfeffer, F.M., Liu, J. and Barrow, C.J., 2021. Direct Observation of Amide Bond Formation in a Plasmonic Nanocavity Triggered by Single Nanoparticle Collisions. Journal of the American Chemical Society, 143(26), pp.9781-9790. DOI: https://doi.org/10.1021/jacs.1c02426
Lejeune, E. and Zhao, B., 2020. Exploring the potential of transfer learning for metamodels of heterogeneous material deformation. Journal of the Mechanical Behavior of Biomedical Materials, p.104276. DOI: https://doi.org/10.1016/j.jmbbm.2020.104276
Liu, B., Wang, B., Zhang, X., Lock, R., Nash, T. and Vunjak-Novakovic, G., 2021. Cell type–specific microRNA therapies for myocardial infarction. Science Translational Medicine, 13(580). DOI: https://doi.org/10.1126/scitranslmed.abd0914
Lou, L., Rubfiaro, A.S., He, J. and Agarwal, A., 2021. Effect of Electrical Stimulation on Spontaneously Beating Dynamics of Cardiac Tissues: An Analysis Using Digital Image Correlation. Advanced Materials Technologies, p.2100669. DOI: https://doi.org/10.1002/admt.202100669
Moon, S., Jones, M.S., Seo, E., Lee, J., Lahann, L., Jordahl, J.H., Lee, K.J. and Lahann, J., 2021. 3D jet writing of mechanically actuated tandem scaffolds. Science Advances, 7(16), p.eabf5289. DOI: https://doi.org/10.1126/sciadv.abf5289
Mozneb, M., Mirtaheri, E., Sanabria, A.O. and Li, C.Z., 2020. Bioelectronic properties of DNA, protein, cells and their applications for diagnostic medical devices. Biosensors and Bioelectronics, 167, p.112441. DOI: https://doi.org/10.1016/j.bios.2020.112441
Nautiyal, P., Zhang, C., Boesl, B. and Agarwal, A., 2021. Interfacial deformation and failure mechanisms at the single-splat length scale revealed in-situ by indentation of cold sprayed aluminum microparticles. Materials Science and Engineering: A, p.141828. DOI: https://doi.org/10.1016/j.msea.2021.141828
Neale, D.B., Muñiz, A.J., Jones, M.S., Kim, D.H., Buschhaus, J.M., Humphries, B.A., Wang, W.Y., Baker, B.M., Raymond, J.E., Solorio, L. and Luker, G.D., 2021. Aligned Networks of Engineered Fibrillar Fibronectin Guide Cellular Orientation and Motility. Small Structures, p.2000137. DOI: https://doi.org/10.1002/sstr.202000137
Orikasa, K., Bacca, N., & Agarwal, A. (2021). Meso/macro-scale ultra-soft materials’ mechanical property evaluation device and testbed. Review of Scientific Instruments, 92(7), 073904. DOI: https://doi.org/10.1063/5.0046282
Pérez-Morelo, D., Stange, A., Lally, R.W., Barrett, L.K., Imboden, M., Som, A., Campbell, D.K., Aksyuk, V.A. and Bishop, D.J., 2020. A system for probing Casimir energy corrections to the condensation energy. Microsystems & nanoengineering, 6(1), pp.1-12. DOI: https://doi.org/10.1038/s41378-020-00221-2
Pollock, C., Javor, J., Stange, A., Barrett, L.K. and Bishop, D.J., 2019. Extreme angle, tip-tilt MEMS micromirror enabling full hemispheric, quasi-static optical coverage. Optics express, 27(11), pp.15318-15326. DOI: https://doi.org/10.1364/OE.27.015318
Psaras, Y., Margara, F., Cicconet, M., Sparrow, A. J., Repetti, G., Schmid, M., … & Toepfer, C. N. (2021). CalTrack: High Throughput Automated Calcium Transient Analysis in Cardiomyocytes. Circulation Research. DOI: https://doi.org/10.1161/CIRCRESAHA.121.318868
Rubfiaro, A.S., Tsegay, P.S., Lai, Y., Cabello, E., Shaver, M., Hutcheson, J., Liu, Y. and He, J., 2021. Scanning Ion Conductance Microscopy Study Reveals the Disruption of the Integrity of the Human Cell Membrane Structure by Oxidative DNA Damage. ACS Applied Bio Materials, 4(2), pp.1632-1639. DOI: https://doi.org/10.1021/acsabm.0c01461
Sharma, A., Wasson, L.K., Willcox, J.A., Morton, S.U., Gorham, J.M., DeLaughter, D.M., Neyazi, M., Schmid, M., Agarwal, R., Jang, M.Y. and Toepfer, C.N., 2020. GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm. Elife, 9, p.e53278. DOI: https://doi.org/10.7554/eLife.53278
Song, J., Korunes‐Miller, J., Banerji, R., Wu, Y., Fazeli, S., Zheng, H., Orr, B., Morgan, E., Andry, C., Henderson, J. and Miller, N.S., 2021. On‐Site, On‐Demand 3D‐Printed Nasopharyngeal Swabs to Improve the Access of Coronavirus Disease‐19 Testing. Global Challenges, 5(11), p.2100039. DOI: https://doi.org/10.1002/gch2.202100039
Song, J., Michas, C., Chen, C. S., White, A. E., & Grinstaff, M. W. (2021). Controlled Cell Alignment Using Two‐Photon Direct Laser Writing‐Patterned Hydrogels in 2D and 3D. Macromolecular Bioscience, 21(5), 2100051. DOI: https://doi.org/10.1002/mabi.202100051
Tsang, J. M., Gritton, H. J., Das, S. L., Weber, T. D., Chen, C. S., Han, X., & Mertz, J. (2021). Fast, multiplane line-scan confocal microscopy using axially distributed slits. Biomedical optics express, 12(3), 1339-1350. DOI: https://doi.org/10.1364/BOE.417286
Ward, T., Tai, W., Morton, S., Impens, F., Van Damme, P., Van Haver, D., Timmerman, E., Venturini, G., Zhang, K., Jang, M.Y. and Willcox, J.A., 2021. Mechanisms of congenital heart disease caused by NAA15 haploinsufficiency. Circulation research, 128(8), pp.1156-1169. DOI: https://doi.org/10.1161/CIRCRESAHA.120.316966
October 2019 to September 2020: Project Year 3
Beaulieu, D.R., Davison, I.G., Kılıç, K., Bifano, T.G. and Mertz, J., 2020. Simultaneous multiplane imaging with reverberation two-photon microscopy. Nature methods, 17(3), pp.283-286. DOI: https://doi.org/10.1038/s41592-019-0728-9
Chen, F., Panday, N., Li, X., Ma, T., Guo, J., Wang, X., Kos, L., Hu, K., Gu, N. and He, J., 2020. Simultaneous mapping of nanoscale topography and surface potential of charged surfaces by scanning ion conductance microscopy. Nanoscale, 12(40), pp.20737-20748. DOI: https://doi.org/10.1039/D0NR04555A
Christopher, J.W., Vutukuru, M., Lloyd, D., Bunch, J.S., Goldberg, B.B., Bishop, D.J. and Swan, A.K., 2019. Monolayer MoS 2 strained to 1.3% with a microelectromechanical system. Journal of Microelectromechanical Systems, 28(2), pp.254-263. DOI: https://doi.org/10.1109/JMEMS.2018.2877983
Davidson, C.D., Jayco, D.K.P., Matera, D.L., DePalma, S.J., Hiraki, H.L., Wang, W.Y. and Baker, B.M., 2020. Myofibroblast activation in synthetic fibrous matrices composed of dextran vinyl sulfone. Acta biomaterialia, 105, pp.78-86. DOI: https://doi.org/10.1016/j.actbio.2020.01.009
Fine, B. and Vunjak-Novakovic, G., 2020. Heart regeneration in mouse and human: a bioengineering perspective. Current opinion in physiology, 14, pp.56-63. DOI: https://doi.org/10.1016/j.cophys.2020.01.004
Fleischer, S., Tavakol, D. N., and Vunjak-Novakovic, G., 2020. From Arteries to Capillaries: Approaches to Engineering Human Vasculature. Adv. Funct. Mater. (30)1910811. DOI: https://doi.org/10.1002/adfm.201910811
Guo, J., Rubfiaro, A.S., Lai, Y., Moscoso, J., Chen, F., Liu, Y., Wang, X. and He, J., 2020. Dynamic single-cell intracellular pH sensing using a SERS-active nanopipette. Analyst, 145(14), pp.4852-4859. DOI: https://doi.org/10.1039/D0AN00838A
Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C.L., Lindberg, E.L., Kanda, M., Polanski, K., Heinig, M., Lee, M., Nadelmann, E.R., Roberts, K., Tuck, L., Fasouli, E.S., DeLaughter, D.M., McDonnough, B., Wakimoto, H., Gorham, J., Samari, S., Mahbubani, K.T., Saeb-Parsy, K., Patone, G., Boyle, J.J., Zhang, H., Zhang, H., Viveiros, A., Oudit, G.Y., Bayraktar, O.A., Seidman, C.E., Noseda, M., Hubner, N. and Teichmann, S.A., 2020. Cells of the adult human heart. Nature, 588(7838), pp.466-472. DOI: https://doi.org/10.1038/s41586-020-2797-4
Mozneb, M., Mirza, A. M., & Li, C. Z., 2019. Non-Invasive Plasmonic Based Real Time Characterization of Cardiac Drugs on Cardiomyocytes Functional Behavior. Analytical Chemistry. DOI: https://doi.org/10.1021/acs.analchem.9b04956
Pandey, P., Garcia, J., Guo, J., Wang, X., Yang, D. and He, J., 2019. Differentiation of metallic and dielectric nanoparticles in solution by single-nanoparticle collision events at the nanoelectrode. Nanotechnology, 31(1), p.015503. DOI: https://doi.org/10.1088/1361-6528/ab4445
Pandey, P., Ghimire, G., Garcia, J., Rubfiaro, A., Wang, X., Tomitaka, A., Nair, M., Kaushik, A. and He, J., 2020. Single-entity approach to investigate surface charge enhancement in magnetoelectric nanoparticles induced by AC magnetic field stimulation. ACS Sensors. DOI: https://doi.org/10.1021/acssensors.0c00664
Pollock, C., Pardo, F., Imboden, M. and Bishop, D.J., 2020. Open loop control theory algorithms for high-speed 3D MEMS optical switches. Optics Express, 28(2), pp.2010-2019. DOI: https://doi.org/10.1364/OE.367554
Sarwar, M., Leichner, J., Naja, G.M. and Li, C.Z., 2019. Smart-phone, paper-based fluorescent sensor for ultra-low inorganic phosphate detection in environmental samples. Microsystems & Nanoengineering, 5(1), pp.1-10. DOI: https://doi.org/10.1038/s41378-019-0096-8
Shroff, S.N., Das, S.L., Tseng, H.A., Noueihed, J., Fernandez, F., White, J.A., Chen, C.S. and Han, X., 2020. Voltage Imaging of Cardiac Cells and Tissue Using the Genetically Encoded Voltage Sensor Archon1. Iscience, 23(4), p.100974. DOI: https://doi.org/10.1016/j.isci.2020.100974
Song, H.H.G., Lammers, A., Sundaram, S., Rubio, L., Chen, A.X., Li, L., Eyckmans, J., Bhatia, S.N. and Chen, C.S., 2020. Transient support from fibroblasts is sufficient to drive functional vascularization in engineered tissues. Advanced Functional Materials, 30(48), p.2003777. DOI: https://doi.org/10.1002/adfm.202003777
Song, J., Michas, C., Chen, C.S., White, A.E. and Grinstaff, M.W., 2020. From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two-Photon Polymerization. Advanced Healthcare Materials, 9(1), p.1901217. DOI: https://doi.org/10.1002/adhm.201901217
Song, J., Michas, C., Chen, C.S., White, A.E. and Grinstaff, M.W., 2020. From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two‐Photon Polymerization. Advanced Healthcare Materials, 9(1), p.1901217. DOI: https://doi.org/10.1002/adhm.201901217
Thomas, T., Rubfiaro, A.S., Nautiyal, P., Brooks, R., Dickerson, D., He, J. and Agarwal, A., 2020. Extrusion 3D Printing of Porous Silicone Architectures for Engineering Human Cardiomyocyte-Infused Patches Mimicking Adult Heart Stiffness. ACS Applied Bio Materials, 3(9), pp.5865-5871. DOI: https://doi.org/10.1021/acsabm.0c00572
Toepfer, C.N., Garfinkel, A.C., Venturini, G., Wakimoto, H., Repetti, G., Alamo, L., Sharma, A., Agarwal, R., Ewoldt, J.F., Cloonan, P. and Letendre, J., 2020. Myosin sequestration regulates sarcomere function, cardiomyocyte energetics, and metabolism, informing the pathogenesis of hypertrophic cardiomyopathy. Circulation, 141(10), pp.828-842. DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.042339
Wagner, K.T., Nash, T.R., Liu, B., Vunjak-Novakovic, G. and Radisic, M., 2020. Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip. Trends in Biotechnology. DOI: https://doi.org/10.1016/j.tibtech.2020.08.005
Books, Book Chapters
Mozneb, M., Smothers, C., Rodriguez, P. & Li, C.-Z., 2019. Electrochemical Analysis of Single Cells. In R.N. Krishnaraj and R.K. Sani (Eds.), Bioelectrochemical Interface Engineering (pp. 55-76). Hoboken, NJ: John Wiley & Sons, Inc. DOI: https://doi.org/10.1002/9781119611103.ch4
Nautiyal, P., Boesl, B. and Agarwal, A., 2020. In-situ Mechanics of Materials. Springer International Publishing. DOI: https://doi.org/10.1007/978-3-030-43320-8
Zhao Y., Eng G., Li B.W., Radisic M. & G. Vunjak-Novakovic, 2020. Cardiac Tissue Engineering. In Lanza, R., Langer, R., & Vacanti, J. P. (Eds.). Principles of Tissue Engineering 5th ed. (Chapter 32). San Diego, United States: Elsevier Science Publishing Co Inc. DOI: https://doi.org/10.1016/B978-0-12-818422-6.00033-2
October 2018 to September 2019: Project Year 2
Barrett, L. K., Stark, T., Reeves, J., Lally, R., Stange, A., Pollock, C., Imboden, M., & Bishop, D. J. (2019). A Large Range of Motion 3D MEMS Scanner with Five Degrees of Freedom. Journal of Microelectromechanical Systems, 28(1), 170-179. DOI: https://doi.org/10.1109/JMEMS.2018.2886653
Chen, F., Manandhar, P., Ahmed, M. S., Chang, S., Panday, N., Zhang, H., Moon, J. H., & He, J. (2019). Extracellular Surface Potential Mapping by Scanning Ion Conductance Microscopy Revealed Transient Transmembrane Pore Formation Induced by Conjugated Polymer Nanoparticles. Macromolecular Bioscience, 19(2), 1800271. DOI: https://doi.org/10.1002/mabi.201800271
Chen, T., & Vunjak-Novakovic, G. (2019). Human Tissue-Engineered Model of Myocardial Ischemia–Reperfusion Injury. Tissue Engineering Part A, 25(9-10), 711-724. DOI: https://doi.org/10.1089/ten.tea.2018.0212
Cheng, D., Jayne, R. K., Tamborini, A., Eyckmans, J., White, A. E., & Chen, C. S. (2019). Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography. Biofabrication, 11(2), 021001. DOI: https://doi.org/10.1088/1758-5090/ab047f
Kumar, R., Welle, A., Becker, F., Kopyeva, I., & Lahann, J. (2018). Substrate-Independent Micropatterning of Polymer Brushes Based on Photolytic Deactivation of Chemical Vapor Deposition Based Surface-Initiated Atom-Transfer Radical Polymerization Initiator Films. ACS Applied Materials & Interfaces, 10(38), 31965-31976. DOI: https://doi.org/10.1021/acsami.8b11525
Lu, W., Jiao, Y., Gao, Y., Qiao, J., Mozneb, M., Shuang, S., Dong, D., & Li, C. Z. (2018). Bright Yellow Fluorescent Carbon Dots as a Multifunctional Sensing Platform for the Label-Free Detection of Fluoroquinolones and Histidine. ACS Applied Materials & Interfaces, 10(49), 42915-42924. DOI: https://doi.org/10.1021/acsami.8b16710
Ma, T., Guo, J., Chang, S., Wang, X., Zhou, J., Liang, F., & He, J. (2019). Modulating and probing the dynamic intermolecular interactions in plasmonic molecule-pair junctions. Physical Chemistry Chemical Physics. DOI: https://doi.org/10.1039/C9CP02030F
Mirtaheri, E., & Li, C. Z. (2019). Wearable Biomedical Devices: State of the Art, Challenges, and Future Perspectives. The Electrochemical Society Interface, 28(3), 71-74. https://doi.org/10.1149/2.F10193IF
Pollock, C., Barrett, L. K., del Corro, P. G., Stange, A., Bifano, T. G., & Bishop, D. J. (2019). PWM as a Low Cost Method for the Analog Control of MEMS Devices. Journal of Microelectromechanical Systems, 28(2), 245-253. DOI: https://doi.org/10.1109/JMEMS.2019.2891205
Reeves, J. B., Jayne, R. K., Barrett, L., White, A. E., & Bishop, D. J. (2019). Fabrication of multi-material 3D structures by the integration of direct laser writing and MEMS stencil patterning. Nanoscale, 11(7), 3261-3267. DOI: https://doi.org/10.1039/C8NR09174A
Ronaldson-Bouchard, K., Teles, D., Yeager, K., Ma, S. P., Chen, T., Song, L. J., Morikawa, K., Wobma, H. M., Vasciaveo, A., Ruiz, E.C., Yazawa, M., & Vunjak-Novakovic, G. (2019). Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype. Nature Protocols, 14, 2781–2817. DOI: https://doi.org/10.1038/s41596-019-0189-8
Sarwar, M., Rodriguez, P., & Li, C. Z. (2019). Sweat-Based in Vitro Diagnostics (IVD): From Sample Collection to Point-of-Care Testing (POCT). Journal of Analysis and Testing, 3(1), 80-88. DOI: https://doi.org/10.1007/s41664-019-00097-w
Skylar-Scott, M. A., Uzel, S. G., Nam, L. L., Ahrens, J. H., Truby, R. L., Damaraju, S., & Lewis, J. A. (2019). Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels. Science Advances, 5(9), eaaw2459. DOI: https://doi.org/10.1126/sciadv.aaw2459
Stange, A., Imboden, M., Javor, J., Barrett, L. K., & Bishop, D. J. (2019). Building a Casimir metrology platform with a commercial MEMS sensor. Microsystems & Nanoengineering, 5(1), 14. DOI: https://doi.org/10.1038/s41378-019-0054-5
Steier, A., Muñiz, A., Neale, D., & Lahann, J. (2019). Emerging Trends in Information‐Driven Engineering of Complex Biological Systems. Advanced Materials, 1806898. DOI: https://doi.org/10.1002/adma.201806898
Thomas, T., Zhang, C., Nautiyal, P., Boesl, B., & Agarwal, A. (2019). 3D Graphene Foam Reinforced Low-Temperature Ceramic with Multifunctional Mechanical, Electrical, and Thermal Properties. Advanced Engineering Materials. DOI: https://doi.org/10.10.1002/adem.201900085
Toepfer, C. N., Sharma, A., Cicconet, M., Garfinkel, A. C., Mücke, M., Neyazi, M. & Ewoldt, J. (2019). SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes. Circulation Research, 124(8), 1172-1183. DOI: https://doi.org/10.1161/CIRCRESAHA.118.314505
Toepfer, C. N., Wakimoto, H., Garfinkel, A. C., McDonough, B., Liao, D., Jiang, J., Tai, A. C., Gorham, J. M., Lunde, I. G., Lun, M., Lynch 4th, T. L., McNamara, J. W., Sadayappan, S., Redwood C. S., Watkins, H. C., Seidman, J. G., & Seidman, C. E. (2019). Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. Science Translational Medicine, 11(476), eaat1199. DOI: https://doi.org/10.1126/scitranslmed.aat1199
Tong, L., Mozneb, M., Bravo, E., Ferrando, V., & Li, C. Z. (2019). Whole cell analysis ranging from intercellular assay to organ on a chip. TrAC Trends in Analytical Chemistry. DOI: https://doi.org/10.1016/j.trac.2019.05.021
Venkidasubramonian, G., Kratzer, D., Trouillet, V., Zydziak, N., Franzreb, M., Barner, L., & Lahann, J. (2018). Surface-initiated RAFT polymerization from vapor-based polymer coatings. Polymer, 150, 26-34. DOI: https://doi.org/10.1016/j.polymer.2018.06.073
Vutukuru, M., Christopher, J. W., Pollock, C., Bishop, D. J., & Swan, A. K. (2019). Modeling and Thermal Metrology of Thermally Isolated MEMS Electrothermal Actuators for Strain Engineering of 2D Materials in Air. Journal of Microelectromechanical Systems, 28(3), 550-557. DOI: https://doi.org/10.1109/JMEMS.2019.2902757
Zhu, X., Sarwar, M., Zhu, J. J., Zhang, C., Kaushik, A., & Li, C. Z. (2019). Using a glucose meter to quantitatively detect disease biomarkers through a universal nanozyme integrated lateral fluidic sensing platform. Biosensors and Bioelectronics, 126, 690-696. DOI: https://doi.org/10.1016/j.bios.2018.11.033
October 2017 to September 2018: Project Year 1
Ba, C., Tsang, J.-M., & Mertz, J. (2018). Fast hyperspectral phase and amplitude imaging in scattering tissue. Optics Letters. 43, 2058. DOI: https://doi.org/10.1364/OL.43.002058
Badon, A. & Mertz, J. (2018). Extended Depth of Field in Confocal Microscopy. In proceedings of Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optical Society of America, 2018). paper BF4C.5. DOI: https://doi.org/10.1364/BRAIN.2018.BF4C.5
Chang, J., Holyoak, M., Kannell, G., Beacken, M., Imboden, M., & Bishop, D. J. (2018). High Performance, Continuously Tunable Microwave Filters using MEMS Devices with Very Large, Controlled, Out-of-Plane Actuation. Journal of Microelectromechanical Systems, 27(6): 1135-1147. DOI: https://doi.org/10.1109/JMEMS.2018.2871657
Chen, T. & Vunjak-Novakovic, G. (2018). In Vitro Models of Ischemia-Reperfusion Injury. Regenerative Engineering and Translational Medicine. DOI: https://doi.org/10.1007/s40883-018-0056-0
Chopra, Anant, Kutys, Matthew L., Zhang, Kehan, Polacheck, William J., Sheng, Calvin C., Luu, Rebeccah J., Eyckmans, Jeroen, Hinson, J. Travis, Seidman, Jonathan G., Seidman, Christine E., Chen, Christopher S. (2018). Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Developmental Cell, 44(1). https://doi.org/10.1016/j.devcel.2017.12.012
Christopher, J.W., Vutukuru, M., Lloyd, D., Bunch, J.S., Goldberg, B.B., Bishop, D.J., Swan, A.K. (2019). Monolayer MoS2 Strained to 1.3% With a Microelectromechanical System, Journal of Microelectromechanical Systems 28(2): 254-263. DOI: https://doi.org/10.1109/JMEMS.2018.2877983
Del Corro, P.G., Imboden, M., Pérez, D. J., Bishop, D. J., & Pastoriza, H. (2018). Single ended capacitive self-sensing system for comb drives driven XY nanopositioners. Sensors and Actuators A: Physical, 271(C). DOI: https://doi.org/10.1016/j.sna.2017.11.021
Guo, Jing, Pan, Jie, Chang, Shuai, Wang, Xuewen, Kong, Na, Yang, Wenrong, & He, Jin. (2018). Monitoring the Dynamic Process of Formation of Plasmonic Molecular Junctions during Single Nanoparticle Collisions. Small, 14(15). DOI: https://doi.org/10.1002/smll.201704164
Jay, S.M. & Vunjak-Novakovic, G. (2017). Emerging Impact of Extracellular Vesicles on Tissue Engineering and Regeneration. Tissue Engineering Part A. 23 (21-22), 1210-1211. https://doi.org/10.1089/ten.TEA.2017.0302
Jayne, R.K., Stark, T.J., Reeves, J.B., Bishop, D.J., & White, A.E. (2018). Dynamic Actuation of Soft 3D Micromechanical Structures Using Micro‐Electromechanical Systems (MEMS). Adv. Mater. Technol. 3, 1700293. DOI: https://doi.org/10.1002/admt.201700293
Kumar, Ramya, Kratzer, Domenic, Cheng, Kenneth, Prisby, Julia, Sugai, James, Giannobile, William V., & Lahann, Joerg. (2018). Carbohydrate-Based Polymer Brushes Prevent Viral Adsorption on Electrostatically Heterogeneous Interfaces. Macromolecular Rapid Communications. DOI: https://doi.org/10.1002/marc.201800530
Li, L., Eyckmans, J., & Chen, C.S. (2017). Designer biomaterials for mechanobiology. Nature Materials. 16 (12), 1164 to 1168. DOI: https://doi.org/10.1038/nmat5049
Liu, B., Lee, B.W., Nakanishi, K., Villasante, A., Williamson, R., Metz, J., Kim, J., Kanai, M., Bi, L., Brown, K., Di Paolo, G., Homma, S., Sims, P.A., Topkara, V.K., & Vunjak-Novakovic, G. (2018). Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Nature Biomedical Engineering 2 (5), 293-303. DOI: https://doi.org/10.1038/s41551-018-0229-7
Nautiyal, Pranjal, Alam, Fahad, Balani, Kantesh, & Agarwal, Arvind. (2018). The Role of Nanomechanics in Healthcare. Advanced Healthcare Materials, 7(3). DOI: https://doi.org/10.1002/adhm.201700793
Nautiyal, Pranjal, Boesl, Benjamin, & Agarwal, Arvind. (2018). The mechanics of energy dissipation in a three-dimensional graphene foam with macroporous architecture. Carbon, 132(C). DOI: https://doi.org/10.1016/j.carbon.2018.02.028
Nautiyal, Pranjal, Mujawar, Mubarak, Boesl, Benjamin, Agarwal, Arvind. (2018) In-situ mechanics of 3D graphene foam based ultra-stiff and flexible metallic metamaterial. Carbon, 137, 502-510. DOI: https://doi.org/10.1016/j.carbon.2018.05.063
Pandey, P., Panday, N., Chang, S., Pang, P., Garcia, J., Wang, X., Fu, Q., & He, J. (2018), Probing Dynamic Events of Dielectric Nanoparticles by a Nanoelectrode‐Nanopore Nanopipette. ChemElectroChem. DOI: https://doi.org/10.1002/celc.201800163
Pollock, Corey, Imboden, Matthias, Stange, Alexander, Javor, Josh, Mahapatra, Koshik, Chiles, Leila, & Bishop, David J. (2018). Engineered PWM Drives for Achieving Rapid Step and Settle Times for MEMS Actuation. Journal of Microelectromechanical Systems, 27(3). DOI: https://doi.org/10.1109/JMEMS.2018.2826843
Reeves, J.B., Jayne, R.K., Stark, T.J., Barrett, L.K., White, A.E., & Bishop, D.J. (2018). Tunable Infrared Metasurface on a Soft Polymer Scaffold. Nano Letters 18 (5), 2802-2806. DOI: https://doi.org/10.1021/acs.nanolett.7b05042
Ronaldson-Bouchard, K. & Vunjak-Novakovic, G. (2018). Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. Cell Stem Cell. 22(3), 310-324. DOI: https://doi.org/10.1016/j.stem.2018.02.011
Ronaldson-Bouchard, K., Ma, S.P., Yeager, K., Chen, T., Song, L., Sirabella, D., Morikawa, K., Teles, D., Yazawa, M., & Vunjak-Novakovic, G. (2018). Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature. 556 (7700), 239-243. DOI: https://doi.org/10.1038/s41586-018-0016-3
Sarwar, M., Rodriguez, P., Li, C. (2019). Sweat-Based in Vitro Diagnostics (IVD): From Sample Collection to Point-of-Care Testing (POCT). Journal of Analysis and Testing 3(1): 80-88. DOI: https://doi.org/10.1007/s41664-019-00097-w
Sentenac, A., & Mertz, J. (2018). Unified description of three-dimensional optical diffraction microscopy: from transmission microscopy to optical coherence tomography: tutorial. J. Opt. Soc. Am. A. 35(5), 748-754. DOI: https://doi.org/10.1364/JOSAA.35.000748
Shain, W.J., Vickers, N.A., Li, J., Han, X., Bifano, T., & Mertz, J. (2018). Axial localization with modulated-illumination extended-depth-of-field microscopy. Biomedical Optics Express. 9(4), 1771-1782. DOI: https://doi.org/10.1364/BOE.9.001771
Shain, W.J., Vickers, N.A., Negash, A., Bifano, T., Sentenac, A., & Mertz, J. (2017). Dual fluorescence-absorption deconvolution applied to extended-depth-of-field microscopy. Optics Letters. 42 (20) 4183-4186. DOI: https://doi.org/10.1364/OL.42.004183
Sharma A., Toepfer CN.., Ward T., Wasson L., Agarwal R., Conner D.A., Hu J.H., Seidman C.E. (2018). CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells. Curr Protoc Hum Genet. 96(1):21.11.1-21.11.20. DOI: https://doi.org/10.1002/cphg.52
Stange, A., Imboden, M., Javor, J., Barrett, L. K., & Bishop, D. J. (2019). Building a Casimir metrology platform with a commercial MEMS sensor. Microsystems & Nanoengineering, 5(1), 14. DOI: https://doi.org/10.1038/s41378-019-0054-5
Steier, A., Muñiz, A., Neale, D., and Lahann, J.* (2019). Emerging Trends in Information-Driven Engineering of Complex Biological Systems. Advanced Materials, 1806898. DOI: https://doi.org/10.1002/adma.201806898
Thomas, T., Zhang, C., Nautiyal, P., Boesl, B. Agarwal, A. (2019). 3D Graphene Foam Reinforced Low-Temperature Ceramic with Multifunctional Mechanical, Electrical, and Thermal Properties. Advanced Engineering Materials, 1900085. DOI: https://doi.org/10.1002/adem.201900085
Toepfer, C.N., et al. (2019). SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes. Circulation Research 124(8): 1172–1183. DOI: https://doi.org/10.1161/CIRCRESAHA.118.314505
Tong, L., Mozneb, M., Bravo, E., Ferrando, V., Li, C. (2019). Whole Cell Analysis Ranging from Intercellular Assay to Organ on a Chip. TrAC Trends in Analytical Chemistry, In Press. DOI: https://doi.org/10.1016/j.trac.2019.05.021
Weber, T.D., & Mertz, J. (2018). Retina and Choroid Imaging with Transcranial Back-illumination. In proceedings of Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optical Society of America, 2018). paper CF3B.8. DOI: https://doi.org/10.1364/TRANSLATIONAL.2018.CF3B.8
Xiao, S., Tseng, H., Gritton, H., Han, X., & Mertz, J. (2018). Video-rate volumetric neuronal imaging using 3D targeted illumination. Scientific Reports 8 (1): 7921. DOI: https://doi.org/10.1038/s41598-018-26240-8
Xiao, S., Tseng, H., Gritton, H., Han, X., and Mertz, J. (2018). Video-rate volumetric neuronal imaging using 3D targeted illumination. In proceedings of Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optical Society of America, 2018), paper BW2C.6. DOI: https://doi.org/10.1364/BRAIN.2018.BW2C.6