CBR Seminar Series: Michael Alosco

CBR Seminar Series: Michael Alosco, February 24, 2025

Title: Beyond Chronic Traumatic Encephalopathy: Long-Term White Matter and Vascular Consequences of Repetitive TBIs

Abstract: Exposure to repetitive traumatic brain injuries (TBIs) from contact and collision sports and other sources have been identified as a risk factor for the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). However, increasing research shows that these repetitive TBIs might also be associated with other pathologies, particularly white matter and vascular injury. These pathologies might contribute to many of the observed symptoms in this setting. This talk will discuss the current science on repetitive TBIs and CTE and then present recent data on the association between repetitive TBIs and white matter and vascular injury from both ex vivo and in vivo studies. It will also present new data that show potentially unique MRI signatures related to repetitive TBIs.

Bio: Dr. Alosco is a clinical neuropsychologist and Associate Professor of Neurology at the Boston University Chobanian & Avedisian School of Medicine, where he serves as the Vice Chair of Research and Co-Director of Clinical Research at the BU CTE Center. His career has been devoted to study methods to detect and diagnosis neurodegenerative diseases, particularly chronic traumatic encephalopathy (CTE).

He has >230 peer-reviewed publications in this field and is the PI of multiple NIH-funded grants. His research has laid the foundation for the development and validation of ways to detect pathologies from repetitive TBIs during life. He hopes his work will ultimately lead to the development of strategies to treat and prevent CTE and Alzheimer’s disease.

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