CBR Seminar Series: Valentina Perosa
CBR Seminar Series: Valentina Perosa, May 13, 2024
Title: Interaction Between Microvascular and AD-related pathology in the Medial Temporal Lobe
Abstract: Cerebral small vessel disease (CSVD), which includes cerebral amyloid angiopathy (CAA) and arteriolosclerosis, often co-occurs with Alzheimer’s disease (AD) pathology. The medial temporal lobe is susceptible to hosting multiple AD pathologies, such as tau-tangles, amyloid-β plaques, phospho-Tar-DNA-Binding-Protein-43 (pTDP-43), as well as CSVD. Whether a causal relationship between these pathologies exists remains largely unknown, but potential linking mechanisms are the dysfunction of perivascular clearance and blood brain barrier leakage. In this presentation, I will provide an overview of studies that used high-resolution in vivo and ex vivo MRI, micro-CT, and deep-learning based measures of pathology to delve into the links between CSVD and AD-related pathology, with a focus on the medial temporal lobe.
Bio:
Education
PhD, University Clinic of Magdeburg 2019
MD University Clinic of Magdeburg 2015
Residency in Neurology, University Clinic of Magdeburg 2016 – 2019
Current Position
Instructor in Neurology at the Translational CAA Research Lab at MGH Harvard
Areas of Interest
How cerebral small vessel disease contributes to cognitive impairment, aging and neurodegenerative disease, enlarged perivascular spaces in patients with CAA, combining post-mortem MRI and histopathology, clearance mechanisms of amyloid β in CAA, interactions between vascular and Alzheimer’s pathology