CBR Seminar Series: Mark Eldaief
CBR Seminar Series: Mark Eldaief, January 22, 2024
Title: The salience network: function, functional neuroanatomy and target for neuropsychiatric disease
Abstract: The salience network is a large-scale cortical system encompassing the rostroventral insula and the rostrodorsal anterior cingulate cortex, among other regions. This network has been implicated in the pathobiology of several neuropsychiatric disorders including Major Depressive disorder, Obsessive-Compulsive Disorder and the behavioral variant of Frontotemporal Dementia. In this talk, I will survey the functional anatomy of the salience network and its hypothesized functions including interoceptive processing, maintaining homeostasis, conflict monitoring and the allocation of neural resources. I will then talk about initiatives in our lab to characterize this network with precision MRI mapping in the individual and with fMRI tasks designed to specifically activate this network (as defined by precision methods). Finally, I will discuss how the salience network may be a putative therapeutic target for Transcranial Magnetic Stimulation (TMS) and for other neuromodulation approaches.
Bio:
Education
MD Columbia University College of Physicians & Surgeons 1999
MS Medical Science, Harvard Medical School
Current Position
Physician Investigator (CI) at Mass General Research institute, Psychiatrist and Assistant Neurologist at Massachusetts General Hospital, and Assistant Professor of Neurology at Harvard Medical School
Areas of Interest
Alzheimer’s disease; brain mapping; concept formation; dementias; models neurological; prefrontal cortex; theta rhythm; transcranial magnetic stimulation.