Biochemistry

• GMS BI 555: Biochemistry A
  Structure and function of macromolecules. Mechanisms of enzyme action, introduction to metabolism of carbohydrates and lipids, biochemical energetics. Four hours of lecture.
• GMS BI 556: Biochemistry B
  Metabolism of amino acids, lipids and nucleotides, control of metabolic processes, hormone action, biochemical genetics, transcriptional and translational events. Four hours of lecture.
• GMS BI 751: Biochemistry and Cell Biology
  Prereq: consent of instructor. Basic principles and concepts of medical school-level biochemistry and cell biology in a one-semester course. Topics include protein structure and function mechanisms of enzyme action nutrition and metabolism membrane structure and receptor signaling cell cycle regulation DNA and RNA structure and function regulation of gene expression and techniques in molecular medicine. Clinical correlations are provided throughout the course. Offner. 6 cr
• GMS BI 759: Integrative Biochemistry
  Prereq: BI 755, BI756, MS 753, and BI782 or equivalent and permission of instructor. This course is an advanced course to follow the first year basic courses. The goal is to present an integrated view of biochemistry and the control of cellular and organismal functions with regard to nutrient utilization. Obesity and diabetes are epidemics in most of the world and these have occurred largely in the last 2 decades. Understanding the how and the why of this is the goal of the course, which focuses on the molecular events of metabolic regulation at numerous levels. Pilch. 4 cr
• GMS BI 776: Gene Targeting in Transgenic Mice
  Prereq: BI 755, 756; MS 753; and consent of instructor. Introduction to the basic theory and practice of an approach applicable to many cell biology problems. The following topics are covered: early mouse development gene targeting into mouse embryos homologous recombination in embryonic stem cells review of practical aspects of the transgenic technology review of selected studies employing transgenic mice and chimeric (gene knockout) mice. Offered alternate years. Ravid. 2 cr
• GMS BI 777: Techniques in Biochemistry, Call, and Molecular Biology
  Prereq: Consent of instructor. Successful basic science research in Biochemistry, Cell, and Molecular Biology requires proposing, developing and testing a novel hypothesis. The generation of a novel hypothesis in turn requires the ability to apply the scientific method and then implement the appropriate techniques to address the experimental question. This course will complement the Foundations in Biomedical Sciences (FIBS) curriculum by providing students with a comprehensive understanding of the experimental methods used in Biomedical research. By the end of this course students will master the concepts behind a wide range of experimental techniques and technologies and then be prepared to apply the most appropriate experimental system to a given biological question. Biochemical knowledge regarding "how things work" will enable students to develop their own experimental research strategies. This course will be offered for 1st year PhD students and will use a traditional lecture approach, problem sets, and discussions. Course materials will include classic papers from the literature, laboratory protocols, and problem sets. A comprehensive final written assignment is designed to test the students' mastery of the subject matter. Layne. 2 cr, Fall sem.
• GMS BI 778: Molecular Mechanisms of Cardiovascular Disease
  The course deals with research topics relevant to cardiovascular disease including lipoproteins, atherosclerosis, oxidative stress, diabetes, hypertension, congenital heart abnormalities, gene therapy, stem cell therapies and others. Emphasis is placed on molecular and cellular mechanisms of normal vascular function and of vascular dysfunction leading to disease. Each session is taught by an expert in the field. The faculty includes several visitors from other US universities. Each student presents an original paper assigned by the instructors and writes and presents a review. Zannis. 2 cr
• GMS BI 782: Molecular Biology
  Prereq: GMS BI 755, 756 or equivalent and consent of instructor. An advanced molecular biology course that places emphasis on the current literature and relevant research techniques. Topics include DNA/RNA/protein synthesis and function analysis of genetic disorders, gene therapy, molecular biology of important cellular processes, and regulation of gene expression. Farmer, Kirsch. 4 cr
• GMS BI 787: Molecular Mechanisms of Growth and Development
  Prereq: GMS BI 755, 756 or equivalent and consent of instructor. Examines the most recent advances in the molecular mechanisms involved in regulation of cell proliferation, differentiation, and development. Control of the cell cycle and regulation of the expression of differentiated function are discussed. The role of extracellular growth factors and nuclear transcriptional regulatory proteins are explored. Students present and actively discuss recent primary research articles. Offered alternate years. Smith, Symes. 2 cr
• GMS BI 789: Methods and Modeling in Molecular Biochemistry
  Prereq: GMS BI 755, 756 or equivalent and consent of instructor. This course teaches the concepts and approaches necessary to model and treat molecular/cellular processes using physical tools and methods including computational strategies. Competence in research methods and modeling approaches enabling exploration and quantification of biological systems is the course goal. Bergethon. 2 cr
• GMS BI 793: Mass Spectrometry, Proteomics and Functional Genomics
  Prereq: BI 755, 756 or equivalent and permission of instructor. The application of mass spectrometry to protein, glycoconjugate and carbohydrate structures has propelled developments in proteomics and functional genomics. This course describes how to use mass spectrometry to answer structural and functional questions in biomedical research. The course explores the background necessary to effectively design mass spectrometric (MS) experiments and interpret data. Students gain a full understanding of modern MS and its effective use in their research. Lectures are devoted to instrumentation, ionization methods and applications to proteins, lipids, carbohydrates, glycoconjugates, nucleic acids and uses of the technology in proteomics, biotechnology and medicine. Costello. 2 cr
• GMS BI 854: Biochemistry Student Seminar
  Required for all Department of Biochemistry MA, PhD and MD/PhD students. Students present and discuss the current literature in molecular and cellular biochemistry. The objective of this course is to develop oral presentation and critical thinking skills. Abraham, Yaglom. 2 cr
• GMS BI 951: Research in Biochemistry
  Var cr
• GMS BI 952: Res Biochem
  

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