The Child and Adolescent Learning and Living Study (CALLS)

CALLSHemifacial microsomia (HFM) is characterized by asymmetric underdevelopment of the face. Although HFM is the second most common craniofacial malformation, there have been few studies of its impact on affected children. We have conducted the first large case-control (1997-2002) and follow-up (2004-2009) studies of children with and without HFM. In our follow-up study, we examined the potential influence of HFM on social-emotional and neuropsychological development. We found that children with HFM between 6-12 years of age were more likely to be shy and nervous, had more social challenges, and experienced greater academic difficulty based on results from neuropsychological screening measures.

We have recently been funded to follow-up this cohort of children with and without HFM when they are between the ages of 11-17 years. In this study, the Child and Adolescent Learning and Living Study (CALLS), we hope to do a more detailed assessment to learn more about the children’s social-emotional development, academic achievement, and neuropsychological functioning. We will directly assess their speech/language patterns, memory, and learning, conduct complete hearing and vision screens, and take photographs so that we can better characterize the typical characteristics or phenotype of HFM. We will also gather information from the children’s parents to learn more about their adaptive behavior, sleep patterns, social participation, and quality of life. In doing so, we expect to identify areas in which strategies are needed to reduce the impact of functional impairments in everyday life and to promote healthy outcomes.

All children with and without HFM who participated in our first follow-up study are eligible to participate in CALLS. To gather the information we need from families who live across the United States and Canada, we will send trained staff to the cities and towns where study subjects live to conduct standardized testing of children and youth and to gather survey data from parents. Educational records and medical history questionnaires will be used to gather updated information about health and educational supports and services. All study participants will be compensated for their time and have the option to receive a summary of their child’s testing results (e.g., to help with educational or vocational planning).

For more information, please see our CALLS Study Overview

Investigators and Study Staff

Investigators:

Werler CALLSMartha Werler, Sc.D.
Principal Investigator
Senior Epidemiologist and Professor,
School of Public Health
Slone Epidemiology Center at Boston University

Speltz CALLSMatthew Speltz, Ph.D.
Co-Principal Investigator
Professor of Psychiatry and Behavioral Sciences
Division Chief, Outpatient Psychiatric Services
University of Washington School of Medicine
Seattle Children’s Hospital Research Institute

Collett CALLSBrent Collett, Ph.D.
Co-Investigator
Assistant Professor,
Dept. of Psychiatry and Behavioral Sciences
University of Washington School of Medicine
Seattle Children’s Hospital Research Institute

Study Consultants:

Chapman CALLSKathy Chapman, Ph.D.
Consultant
Professor and Director of Graduate Studies,
Dept. of Communication Sciences and Disorders
University of Utah

Cloonan CALLSYona Cloonan, Ph.D.
Consultant
University of Pittsburgh

Heike CALLSCarrie Heike, M.D., M.S.
Consultant
Assistant Professor of Pediatrics
University of Washington School of Medicine

Mary KhetaniMary Khetani, Sc.D., O.T.R.
Consultant
Assistant Professor, Dept. of Occupational Therapy
Secondary Appointment,
Human Development and Family Studies
Colorado State University

Starr CALLSJacqueline Starr, Ph.D., M.S., M.P.H.
Consultant
University of Washington

Study Staff (Slone Epidemiology Center):

Crowell CALLSLisa Crowell, R.N.
Research Coordinator



Rosie CALLSMichelle Rosie , B.A.
Psychometrist



Bairos CALLSMichael Bairos, B.S.
Database Analyst



Kneer CALLSKrisandra Kneer, B.S.
Psychometrist

 


Study Staff (Seattle Children’s Hospital Research Institute):

Gangan CALLSAurora Gangan, B.A.
Research Coordinator

Silver-Heilman CALLSKate Silver-Heilman, M.Ed.
Psychometrist

Conner CALLSSharman Conner, M.A.
Study Manager

Daniels CALLSKristen Daniels
Research Data Coordinator

Study Details

Source of Funding:

National Institute of Dental and Craniofacial Research (NIDCR)

Study Period:

July 2010 to 2015

Publications

Here are the published articles from the follow-up study (2004-2009):

Here are the published articles from the case-control study (1997-2002):

Contact Information

Lisa Crowell, R.N.
(617) 734-6006 or 1-888-489-8826
calls@bu.edu