Sherral Devine, PhD
Research Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology
sdevine@bu.edu
Education:
PhD, Bowling Green State University
MA, Bowling Green State University
BA, DePauw University
Research interests:
Dr. Devine has worked as a clinical neuropsychologist at the Framingham Heart Study (FHS) since 1999. She has collaborated with Dr. Rhoda Au in applying the Boston Process Approach (BPA) to research using neuropsychological tests. BPA goes beyond the typically used quantitative scores, adding the wealth of information available in qualitative aspects of an individual’s performance on cognitive tests. Although widely used in clinical settings, research using BPA is severely limited, given the challenges of operationalizing qualitative aspects of an individual’s behavior while taking cognitive tests. Dr. Devine has provided training and supervision to testers to ensure reliable and consistent coding of behavior. Dr. Devine is involved with research at FHS into identification of cognitive biomarkers, especially those caught digitally (i.e., with audio recorders and digital pens), that may reveal risk in the very early (i.e., pre- pre-clinical) stages of dementia.
Active studies:
- Expanding the Pipeline to Graduate Research in Alzheimer’s Disease and Related Dementias (EPGRAD) Program
04/01/2023 – 01/31/2026 (Subcontract PI)
The George Washington University NIH NIA
5R25AG081177-03
Selected recent publications:
- Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez J, Farrer LA. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. Alzheimers Dement. 2025 Sep; 21(9):e70681. PMID: 40951946; PMCID: PMC12434708; DOI: 10.1002/alz.70681;
- Ding H, Lyu C, Karjadi C, Sunderaraman P, Young CB, Mormino EC, Low S, Devine S, Gifford K, Au R, Lin H. Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults. Sci Rep. 2025 Apr 01; 15(1):11104. PMID: 40169870; PMCID: PMC11961701; DOI: 10.1038/s41598-025-95852-8;
- Yang J, Ding H, Li Y, Ang TFA, Devine S, Liu Y, Qiu W, Au R, Ma J, Liu C. Association of mid-age Life’s Essential 8 score with digital cognitive performance and incident Alzheimer’s disease: The Framingham Heart Study. J Alzheimers Dis. 2025 Mar; 104(2):498-508. PMID: 40025717; DOI: 10.1177/13872877251317734;
- Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez J, Farrer LA. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. medRxiv. 2025 Feb 13. PMID: 39990565; PMCID: PMC11844603; DOI: 10.1101/2025.02.11.25322014;
- Yuan J, Tao Q, Ang TFA, Liu C, Devine S, Auerbach SH, Mez J, Farrer LA, Qiu WQ, Au R. The Relationship between Framingham Stroke Risk Profile on Incident Dementia and Alzheimer’s Disease: A 40-Year Follow-Up Study Highlighting Female Vulnerability. Ann Neurol. 2024 Dec; 96(6):1124-1134. PMID: 39404028
- Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Oct 01; 81(10):993-1002. PMID: 38959008; PMCID: PMC11223054; DOI: 10.1001/jamapsychiatry.2024.1678;
- Ding H, Liu C, Li Y, Ang TFA, Devine S, Liu Y, Au R, Doraiswamy PM. Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham Heart Study. Alzheimers Dement (Amst). 2024; 16(1):e12569. PMID: 38545543; PMCID: PMC10966919; DOI: 10.1002/dad2.12569;
- De Anda-Duran I, Sunderaraman P, Searls E, Moukaled S, Jin X, Popp Z, Karjadi C, Hwang PH, Ding H, Devine S, Shih LC, Low S, Lin H, Kolachalama VB, Bazzano L, Libon DJ, Au R. Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts. J Am Heart Assoc. 2024 Jan 16; 13(2):e032733. PMID: 38226519; PMCID: PMC10926794; DOI: 10.1161/JAHA.123.032733;
- Sunderaraman P, De Anda-Duran I, Karjadi C, Peterson J, Ding H, Devine SA, Shih LC, Popp Z, Low S, Hwang PH, Goyal K, Hathaway L, Monteverde J, Lin H, Kolachalama VB, Au R. Design and Feasibility Analysis of a Smartphone-Based Digital Cognitive Assessment Study in the Framingham Heart Study. J Am Heart Assoc. 2024 Jan 16; 13(2):e031348. PMID: 38226510; PMCID: PMC10926817; DOI: 10.1161/JAHA.123.031348;
- Ferretti MT, Ding H, Au R, Liu C, Devine S, Auerbach S, Mez J, Gurnani A, Liu Y, Santuccione A, Ang TFA. Maximizing utility of neuropsychological measures in sex-specific predictive models of incident Alzheimer’s disease in the Framingham Heart Study. Alzheimers Dement. 2024 Feb; 20(2):1112-1122. PMID: 37882354; PMCID: PMC10917035; DOI: 10.1002/alz.13500;
- Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Durant A, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez JB, Farrer LA. A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores. Mol Neurodegener. 2023 Jun 22; 18(1):40. PMID: 37349795; PMCID: PMC10286470; DOI: 10.1186/s13024-023-00633-4;
- Scollard P, Choi SE, Lee ML, Mukherjee S, Trittschuh EH, Sanders RE, Gibbons LE, Joshi P, Devine S, Au R, Dams-O’Connor K, Saykin AJ, Seshadri S, Beiser A, Aparicio HJ, Salinas J, Gonzales MM, Pase MP, Ghosh S, Finney R, Mez J, Crane PK. Ceiling effects and differential measurement precision across calibrated cognitive scores in the Framingham Study. Neuropsychology. 2023 May; 37(4):383-397. PMID: 37276135; PMCID: PMC10247160; DOI: 10.1037/neu0000828;
- Yang J, Ang TFA, Lu S, Liu X, Devine S, Au R, Liu C. Establishing cognitive baseline in three generations: Framingham Heart Study. Alzheimers Dement (Amst). 2023; 15(1):e12416. PMID: 36968621; PMCID: PMC10038074; DOI: 10.1002/dad2.12416;