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Nature Communications Paper on a New Progesterone Biosensor is Out!

March 13th, 2020in News

A progesterone biosensor derived from microbial screening Chloé Grazon, R C. Baer, Uroš Kuzmanović,Thuy Nguyen, Mingfu Chen, Marjon Zamani, Margaret Chern, Patricia Aquino, Xiaoman Zhang, Sébastien Lecommandoux, Andy Fan, Mario Cabodi, Catherine Klapperich, Mark W. Grinstaff, Allison M. Dennis & James E. Galagan Nature Communications volume 11, Article number: 1276 (2020)  Abstract Bacteria are an enormous and largely untapped reservoir of biosensing proteins. We describe an approach to identify and isolate bacterial allosteric transcription... More

RNA Extraction Methods Archive

March 11th, 2020in News

Protocols, papers, and links for nucleic acid extraction from human samples without using a "kit." You can do it! And we can help. Check it out. https://www.bu.edu/klapperich/rna-and-dna-extraction-protocols-and-papers/  

New Molecular Test for Malaria Paper Online!

June 4th, 2019in News

Online article! Work with our partners describes a new way to mine the malaria genome to create primer sets that are 100x more sensitive at detecting malaria when compared to Pf18S rRNA primers. The new assay was validated with human samples. Srinivasa Raju, L., Kamath, S., Chandana Shetty, M., Satpathi, S., More

New Article in Sexually Transmitted Diseases Journal – POC Diagnostics Now and in the Future

November 13th, 2017in News

A new discussion of clinical needs and current advancements in point of care technologies for sexually transmitted infections. Click on the link for the open access version of the paper. Point-of-Care Sexually Transmitted Infection Diagnostics: Proceedings of the STAR Sexually Transmitted Infection—Clinical Trial Group Programmatic Meeting Cristillo, Anthony D.; Bristow, Claire C.;... More

Klapperich Lab Paper Makes Most Downloaded List for LOC in 2016!

November 13th, 2017in News

The Klapperich Lab manuscript describing an integrated paperfluidic diagnostic device to detect high risk HPV at the point of care was on the most downloaded list for Lab on Chip in 2016. The paper describes the culminating work for Dr. Natalia Rodriguez’ Ph.D. thesis. This technology forms the basis for the formation... More

What is the Best Paper for your Molecular Diagnostic Device?

November 13th, 2017in News

Check out our new paper comparing different porous substrates for in situ nucleic acid amplification. Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics. Linnes JC, Rodriguez NM, Liu L, Klapperich CM, Biomed Microdevices. 2016 Apr;18(2):30. doi: 10.1007/s10544-016-0057-z. PMID: 26906904  Free PMC Article

New LOC Paper: A fully integrated paperfluidic molecular diagnostic chip

January 20th, 2016in News

  A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples Abstract Paper diagnostics have successfully been employed to detect the presence of antigens or small molecules in clinical samples through immunoassays; however, the detection of many disease targets relies on the much higher... More

New Paper: Cancer Screening at the POC: Clinical Needs Assessment

January 19th, 2016in News

New CFTCC publication out this week at PLoS ONE. Open access links: Kim CS, Vanture S, Cho M, Klapperich CM, Wang C, et al. (2016), “Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology,” PLoS ONE 11(1): e0145215. doi: 10.1371/journal.pone.0145215 Abstract Well-developed point-of-care (POC) cancer screening tools have the potential to provide better cancer care to patients in both... More