Entorhinal cortex publications:


These articles focus on the physiological properties of neurons in entorhinal cortex, including membrane resonance and membrane potential oscillations (Yoshida et al., 2011; Heys et al., 2010; Giocomo and Hasselmo, 2009, 2008; Giocomo et al., 2007; Fransen et al., 2004; Dickson et al., 2000) and persistent spiking (Yoshida and Hasselmo, 2009; Yoshida et al., 2008; Hasselmo and Brandon, 2008; Tahvildari et al., 2007; Fransen et al., 2006; Egorov et al., 2002). Computational modeling demonstrates how these mechanisms could contribute to the unit firing properties of entorhinal grid cells (Hasselmo, 2008; Hasselmo et al., 2007; Giocomo et al., 2007). Models are supported by unit recording data showing loss of grid cell spatial periodicity during loss of theta rhythm oscillations due to infusions of muscimol into the medial septum (Brandon et al., 2011). Simulations also show how these mechanisms can contribute to unit firing of hippocampal neurons, including context-dependent firing (Hasselmo, 2008; Hasselmo, 2007; Hasselmo and Eichenbaum, 2005) and temporally structured replay (Hasselmo, 2009; 2008). Persistent spiking mechanisms might underlie fMRI activity observed during delay periods in parahippocampal structures (Hasselmo and Stern, 2006; Schon et al., 2005, 2004).
Papers: (Click on "PDF" at end of citation to download PDF files)
PEER REVIEWED JOURNAL ARTICLES:
Brandon, M.P., Bogaard, A.R., Libby, C.P., Connerney, M.A., Gupta, K., Hasselmo, M.E. (2011) Reduction of theta rhythm dissociates gri d cell spatial periodicity from directional tuning. Science, 332: 595-599. Abstract Full text PDF
Yoshida, M., Giocomo, L.M., Boardman, I., Hasselmo, M.E. (2011) Frequency of subthreshold oscillations at different membrane potential voltages in neurons at different anatomical positions on the dorsoventral axis in the rat medial entorhinal cortex. J Neurosci. 31(35 ):12683-94. PMCID: PMC3177240. PDF Hasselmo, M.E., Giocomo. L.M., Brandon, M.P., Yoshida, M. (2010) Cellular dynamical mechanisms for encoding the time and place of even ts along spatiotemporal trajectories in episodic memory. Behav. Brain Res. 215: 261-274. PMCID: PMC2891577. PDF
Heys, J.G., Giocomo, L.M., Hasselmo, M.E. (2010) Cholinergic modulation of the resonance properties of stellate cells in layer II of m edial entorhinal cortex. J. Neurophysiol. 104(1): 258-70. PMCID: PMC2904208. PDF
Zilli, E.A., Hasselmo, M.E. (2010) Coupled noisy spiking neurons as velocity-controlled oscillators in a model of grid cell spatial fi ring. J. Neurosci. 30: 13850-13860. PMCID: PMC2978507 PDF
Giocomo, L.M., Hasselmo, M.E. (2009) Knock-out of HCN1 subunit flattens dorsal-ventral frequency gradient of medial entorhinal neurons in adult mice. Journal of Neuroscience 29(23): 7625-30. PMCID 2729850. PDF
Hasselmo, M.E. (2009) A model of episodic memory: Mental time travel along encoded trajectories using grid cells. Neurobiology of Lea rning and Memory 92(4): 559-73. PDF
Yoshida, M., Hasselmo, M.E. (2009) Persistent firing supported by an intrinsic cellular mechanism in a component of the head direction system. Journal of Neuroscience 29(15): 4945-52. PMCID2704018. PDF
Hasselmo, M.E., Brandon, M.P., Yoshida, M., Giocomo, L.M., Heys, J.G., Fransen, E., Newman, E.L., Zilli, E.A. (2009) A phase code for memory could arise from circuit mechanisms in entorhinal cortex. Neural Networks 22(8):1129-38. PDF
Zilli, E.A., Yoshida, M., Tahvildari, B., Giocomo, L.M., Hasselmo, M.E. (2009) Evaluation of the oscillatory interference model of gri d cell firing through analysis of measured period variance of some biological oscillators. PLoS Comput Biol. 5(11): e1000573. PDF
Giocomo, L.M., Hasselmo, M.E. (2008) Time constant of I(h) differs along dorsal to ventral axis of medial entorhinal cortex. Journal of Neuroscience, 28:9414-25. PDF
Hasselmo, M.E. (2008) Temporally structured replay of neural activity in a model of entorhinal cortex, hippocampus and postsubiculum. Eur. J. Neurosci. 28:1301-1315. PDF
Hasselmo, M.E., Brandon, M.P. (2008) Linking cellular mechanisms to behaviour: Entorhinal persistent spiking and membrane potential oscillations may underlie path integration, grid cell firing and episodic memory. Neural Plasticity, 2008: 658323. PDF
Yoshida, M., Fransen, E., Hasselmo, M.E. (2008) mGluR-dependent persistent firing in entorhinal cortex layer III neurons. Eur. J. Neurosci. 28:1116-26.
Giocomo LM, Zilli EA, Fransen E, Hasselmo ME. (2007) Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing. Science, 315(5819):1719-22. Abstract Full text
Hasselmo ME, Giocomo LM, Zilli EA (2007) Grid cell firing may arise from interference of theta frequency membrane potential oscillations in single neurons. Hippocampus, 17(12): 1252-1271. PDF
Hasselmo ME (2007) Arc length coding by interference of theta frequency oscillations may underlie context-dependent hippocampal unit data and episodic memory function. Learn. Mem. 14: 782-794. PDF
Tahvildari B, Fransen E, Alonso AA, Hasselmo ME. (2007) Switching between "On" and "Off" states of persistent activity in lateral entorhinal layer III neurons. Hippocampus. 17(4):257-63. PDF
Hasselmo, M.E., Stern, C.E. (2006) Mechanisms underlying working memory for novel information. Trends in Cognitive Sciences, 10(11):487-93. PDF
Fransen, E., Tahvildari, B., Egorov, A.V., Hasselmo, M.E. and Alonso, A.A. (2006) Mechanism of graded persistent cellular activity of entorhinal cortex layer V pyramidal neurons. Neuron, 49(5): 735-746. PDF
Schon K, Atri A, Hasselmo ME, Tricarico MD, LoPresti ML, Stern CE (2005) Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans. J Neurosci. 25(40):9112-23 PDF
Schon, K., Hasselmo, M.E., Lopresti, M.L., Tricarico, M.D., and Stern, C.E. (2004) Persistence of parahippocampal representation in the absence of stimulus input enhances long-term encoding: A functional magnetic resonance imaging study of subsequent memory after a delayed match-to-sample task. J. Neurosci. 24: 11088-97. PDF
Fransen, E., Alonso AA, Dickson CT, Magistretti J, Hasselmo, M.E. (2004) Ionic mechanisms in the generation of subthreshold oscillations and action potential clustering in entorhinal layer II stellate neurons. Hippocampus, 14(3):368-84. PDF
Fransen, E., Alonso, A.A. and Hasselmo, M.E. (2002) Simulations of the role of the muscarinic-activated calcium-sensitive non-specific cation current I(NCM) in entorhinal neuronal activity during delayed matching tasks. J. Neurosci. 22(3):1081-1097. PDF
Egorov, A.V., Hamam, B.N., Fransen, E., Hasselmo, M.E., Alonso, A.A. (2002) Graded persistent activity in entorhinal cortex neurons. Nature 420(6912):173-8. PDF
Stern, C.E., Sherman, S.J., Kirchhoff, B.A. and Hasselmo, M.E. (2001) Medial temporal and prefrontal contributions to working memory tasks with novel and familiar stimuli. Hippocampus, 11: 337-346. PDF
Dickson, C.T., Magistretti, J., Shalinsky, M.H., Fransen, E., Hasselmo, M.E., Alonso, A. (2000) Properties and role of I(h) in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons. J Neurophysiol. 83(5):2562-79. PDF
Sohal, V. and Hasselmo, M.E. (2000) A model for experience-dependent changes in the responses of inferotemporal neurons. Network: Comp. Neural Syst. 11: 169-190. PDF
Fransen, E., Wallenstein, G.V., Alonso, A., Dickson, C.T. and Hasselmo, M.E. (1999) A biophysical simulation of intrinsic and network properties of entorhinal cortex. Neurocomputing 26-27: 375-380.
JOURNAL EDITOR
Hasselmo, M.E., Moser, E.I. and Moser, M.-B. (2008) Special Issue on Grid Cells. Hippocampus, Volume 18(12).
BOOK CHAPTERS:
Hasselmo, M.E., Fransen, E., Dickson, C., Alonso, A. (2000) Computational modeling of entorhinal cortex. Ann. NY Acad. Sci. 911: 418-446.
Fransen, E., Wallenstein, G.V., Alonso, A., Dickson, C.T. and Hasselmo, M.E. (1998) A biophysical simulation of intrinsic and network properties of entorhinal cortex. In: J.M. Bower (ed.) Neurocomputing: Proceedings of the Computational Neuroscience Conference, Elsevier.