Highlights from
the 12th Annual Translational Science Symposium

Advancing Translational Science Through Cutting-Edge Technology

Held on March 19, 2025 | 8:00 AM – 3:30 PM
Duan Family Center for Computing and Data Sciences

665 Commonwealth Ave, 17th Floor, Boston, MA

The Boston University Clinical & Translational Science Institute’s 12th annual Translational Science Symposium, In Memory of David Seldin, MD, PhD, spotlighted innovations in artificial intelligence and regenerative medicine. The event brought together researchers and experts for meaningful dialogue, collaboration, and the presentation of groundbreaking translational research. Catch up on the symposium sessions—recordings available here.

Featuring Keynote Speaker

Roy Perlis, MD, MSc.

Associate Chief for Research in the Department of Psychiatry, MGH
Director of the Center for Quantitative Health, MGH
Professor of Psychiatry, Harvard Medical School

Dr. Roy Perlis delivered the keynote address, drawing on his extensive research at the intersection of machine learning, genomics, and brain disease. His talk emphasized the growing role of AI in translational science and the future of personalized medicine.



Announcing
the 2025 BU CTSI Poster Session Winners!


Kevin Chen
🏆 Kevin Chen – 1st Place

Boston University Chobanian & Avedisian School of Medicine

Kevin Chen is a third-year MD/PhD student in Dr. Darrell Kotton’s lab at Boston University’s Center for Regenerative Medicine (CReM), where he is focused on developing and testing airway stem cell therapies. Since beginning the MD/PhD program in 2020—at the height of the COVID-19 pandemic—Kevin has been motivated by the intersection of science and medicine and the collaborative spirit it requires. Inspired by CReM’s open-source, team-based approach to science, he is committed to translational research that advances new therapeutic options through transparency and collaboration.

Transplanting Airway Basal Cells to Rescue CFTR Function
This project explores a novel strategy to treat cystic fibrosis (CF) by reconstituting the airway stem cell compartment with autologous basal cells carrying a functional CFTR gene. Wild-type primary basal cells were transplanted into CFTR-deficient mice, resulting in airway epithelial regeneration and restoration of CFTR-dependent electrophysiologic current to levels comparable to those in healthy controls. These findings represent a critical step toward developing a mutation-independent, potentially curative therapy for CF patients who do not benefit from current treatments.


Varuna Jasodanand
🏆 Varuna Jasodanand – 1st Place

Boston University Chobanian & Avedisian School of Medicine

Originally from Mauritius Island, Varuna Jasodanand is a PhD candidate in Behavioral Neuroscience at Boston University, working in Dr. Vijaya Kolachalama’s lab. Her research focuses on implementing and validating machine learning methods to improve the assessment and understanding of Alzheimer’s disease and related dementias.

AI for Biological Alzheimer’s Disease Diagnosis and Staging
This poster presents a multi-modal machine learning approach designed to evaluate amyloid and tau positivity in older adults. By integrating diverse data sources—including demographics, medical history, cognitive assessments, neuroimaging, and fluid biomarkers—the model supports a more personalized and precise method for diagnosing and staging biological Alzheimer’s disease.


KathrynAnn Odamah
🥉 KathrynAnn Odamah – 3rd Place

Boston University College of Arts and Sciences

KathrynAnn Odamah is a fifth-year Cellular & Molecular Biology PhD candidate in Dr. Hengye Man’s lab. She received her B.S. in Neuroscience from Duke University and enjoys training for powerlifting competitions and learning about therapeutic innovations for X-linked neurodevelopment disorders.

Investigation of Rescue Strategies for Nexmif-Dependent Autism Spectrum Disorder
Kathryn’s poster investigates the use of genetic restoration strategies to rescue neuronal impairments and behavioral deficits in a Nexmif knockout mouse model of Autism Spectrum Disorder. Her work demonstrates both DNA methylation inhibitors and CRISPR activation system to induce reactivation of the silenced Nexmif allele in female mice, and postnatal lentiviral restoration in male mice.


Braden Pate
🥉 Braden Pate – 3rd Place

Boston University Chobanian & Avedisian School of Medicine

Originally from Butler, PA, Braden Pate earned his bachelor’s in Biology from Colorado State University and now researches in the Vanuytsel Lab at the Center for Regenerative Medicine (CReM).

Sickle Cell Disease-Specific iPSC Platform as a Preclinical Screening Tool
This project leverages patient-derived iPSCs to model sickle cell disease, enabling tailored drug testing on erythroid progenitor cells. By capturing individual genetic backgrounds, Braden’s platform may help personalize and improve treatment strategies in the clinic.