Skip to Main Content
Boston University
  • Bostonia
  • BU Today
  • The Brink
  • University Publications

    • Bostonia
    • BU Today
    • The Brink
  • School & College Publications

    • The Record
Other Publications
BU Today
  • Sections
News, Opinion, Community

Profs Probe the Science of Sleep

Part two: What dreams are made of

February 28, 2007
  • Taylor McNeil
Twitter Facebook
Subimal Datta, a MED professor of psychiatry, is investigating REM sleep memory processing at the molecular level. Photo by Vernon Doucette

Part two of a four-part series.

We spend a third of our lives sleeping, and 20 percent of that time we’re dreaming. Subimal Datta, a professor of psychiatry at the School of Medicine, wants to know why — and has spent his career as a sleep researcher finding out how it all works.

Our brain is almost as active during sleep as it is during wakefulness, Datta notes, and there’s at least one good reason: that’s when we’re consolidating memories. “Whatever we learned during the wake state, which is in the short-term memory, is being processed,” he says. It’s like a library card catalog system: your brain records what the memory is and where it’s shelved, so the next time it needs to retrieve a memory, it knows where to go — emotional memories in the amygdala, spatial memories in the hippocampus, for instance.

Some sleep basics: after we drift off, we enter what’s called non-REM sleep, which experts divide into four stages with different brain wave patterns. Then, a little less than 90 minutes later, we’re pushed by an internal mechanism into REM sleep, and the pattern cycles back and forth throughout the night, with REM sleep periods gradually lengthening as the night progresses.

REM sleep is clearly important, since that’s when memory is processed, despite the oddity of accompanying dreams. But, like all mammals, our bodies are paralyzed during REM sleep, and for most animals, which are usually some other animal’s prey, that’s dangerous. So much so that certain animals, like mice, have frequent and brief REM states; they may need to run on short notice. Still, at various points, their bodies are paralyzed. And like other mammals, we humans are not just paralyzed; our autonomic functions are out of our control. “The temperature outside could go up or down, yet nothing is controlling body temperature. Respiration can go up or way down,” Datta says. Blood pressure can spike up or down, and that’s one reason why, as morning comes around and we are in longer REM sleep states, more heart attacks occur then than at any other time of day.

So what could be worth putting ourselves at this risk? It’s the memory consolidation that occurs in REM sleep, Datta says. “Our survival depends on our learning. When we stop learning, we’re dead, if you think of it philosophically.” To process memories, the brain needs a lot of energy, so it shuts down most other systems. “It’s like us,” he says. “We can do multitasking, but when we have something very important, we need to focus, and this is what the brain does.”

Datta and his colleagues in the MED Sleep Research Laboratory, which he directs, have identified the cells that are critical for REM sleep memory processing, and they are now working at the molecular level to understand these mechanisms. This basic research, he notes, has potentially big payoffs for pharmacological interventions to treat some sleep disorders, like narcolepsy, which causes victims to suddenly fall asleep during the day. If he finds the exact receptors that turn on and off different sleep signals, drugs could be designed to target those receptors alone.

And the dreams themselves? From the ancients to Freud and on to this day, dreams have been seen as having meaning, either as omens or as signals of a hidden past. Datta will have none of that. Dreaming is simply a noisy by-product of the memory consolidation that’s happening during REM sleep, he says. While newer memories are being laid down in the long-term memory areas of the brain, they run up against random other memories lodged nearby, activating them. The brain just tries to make some sense of it all by creating a narrative, even if the narrative makes little or no logical sense. It’s random noise in the signal, he says, nothing more.

Datta’s conclusion, that REM sleep is essential because its memory consolidation facilitates learning, isn’t the only possible interpretation of the dream state or of sleep in general. Patrick McNamara, a MED assistant professor of neurology, who’s been looking at this question from the point of view of evolutionary biology, is developing several theories of his own.

One is that REM sleep “undoes something that occurs in non-REM sleep,” he says. “REM and non-REM are controlled by different sets of genes, which are in some ways in conflict with each other. In non-REM you might have rising levels of certain hormones that in REM get opposed by rising levels of another hormone. So you have a sort of arms race between these two sleep states.” For example, in developing organisms, non-REM’s slow-wave sleep is associated with very high productions of growth hormone. But REM sleep releases somatostatins, which inhibit the release of growth hormones. “So REM sleep modulates the rate of growth,” McNamara says.

Another theory suggests that morning moods, which have been shown to be a reflection of emotions produced during REM sleep, might be a signal used for evolutionary purposes.

Still, McNamara says, there’s no clear answer about the purpose of REM sleep, in part because historically it hasn’t been studied much. “I think REM sleep was just such a difficult problem — it’s not like other biologic functions, that you can say this chemical does that and you know why. With REM sleep, it’s got all these paradoxical properties, so it’s harder to figure out what it could possibly be doing.”

The purpose of non-REM sleep is better understood. It apparently has a restorative function, helping repair tissue and realign biological rhythms, says McNamara, although exactly how this happens still isn’t known. Non-REM sleep also produces a number of antibodies, adds Datta. “If you have a cold or infection, to fight against those germs, you need antibodies. During that part of sleep, mostly in slow-wave sleep, those antibodies are synthesized,” he says. “That’s why when you have a cold or infection, you get more sleepy.”

Check
BU Today tomorrow to read part three of “Profs Probe the Science of Sleep.” Click here to read "Part one: Cracking the circadian code."

This article originally ran in the Winter 2006–2007 edition of Bostonia.

Taylor McNeil can be reached at tmcneil@bu.edu.

Explore Related Topics:

  • Faculty
  • Research
  • Share this story

Share

Profs Probe the Science of Sleep

Share

  • Twitter
  • Facebook
  • Reddit
  • LinkedIn
  • Email
  • Taylor McNeil

    Taylor McNeil Profile

Latest from BU Today

  • Education

    What’s Behind the Rise in Violence Against Teachers?

  • Fine Arts

    How I Made This: Jacob Whitchurch (CFA’26)

  • Things-to-do

    To Do Today: Seaport Sweat

  • Film & TV

    Did You Win Free Tickets to See Mission: Impossible—The Final Reckoning Tonight?

  • COMMENCEMENT 2025

    Experience BU’s 2025 Commencement from a Terrier Point of View

  • Obituaries

    Remembering Leslie Epstein, Pillar of BU’s Creative Writing Program

  • Voices & Opinion

    POV: This Memorial Day, Remember BU’s Fallen Heroes by Visiting the New Online Honor Wall

  • University News

    23 Charles River Campus Faculty Promoted to Full Professor

  • Commencement 2025

    Photos: A Look Back at BU’s Commencement

  • Theatre

    It’s “Prom Season” at Wheelock Family Theatre

  • Things-to-do

    Six Spots to Check Out This Memorial Day in Boston

  • Commencement

    Video: Class of 2025: What We’ll Take with Us as We Begin a New Chapter

  • Health & Medicine

    What Does Biden’s Cancer Diagnosis Mean?

  • Watch Now

    BU’s Class of 2025: What Are Your Plans After Graduating?

  • Fitness

    BU Sports Rehab Therapists on Jayson Tatum’s Achilles Injury and Recovery Ahead

  • Commencement 2025

    Sights and Sounds from Boston University’s Class of 2025 Commencement

  • Commencement 2025

    Video: 2025 Graduate Jayde Best: “I Ended Up Exactly Where I Wanted to Be”

  • Commencement 2025

    “Empathy Is Essential,” BU Commencement Speaker Emily Deschanel Tells 2025 Graduates

  • Voices & Opinion

    I’m a Business Professor Who Asked Dozens of Former Students How They Define Success

  • Commencement 2025

    Chobanian & Avedisian School of Medicine Convocations a Joyous Affair

Section navigation

  • Sections
  • Must Reads
  • Videos
  • Series
  • Close-ups
  • Archives
  • About + Contact
Get Our Email

Explore Our Publications

Bostonia

Boston University’s Alumni Magazine

BU Today

News, Opinion, Community

The Brink

Pioneering Research from Boston University

  • Twitter
  • Facebook
  • Youtube
  • LinkedIn
  • Instagram
  • Weibo
  • TikTok
© Boston University. All rights reserved. www.bu.edu
© 2025 Trustees of Boston UniversityPrivacy StatementAccessibility
Boston University
Notice of Non-Discrimination: Boston University prohibits discrimination and harassment on the basis of race, color, natural or protective hairstyle, religion, sex or gender, age, national origin, ethnicity, shared ancestry and ethnic characteristics, physical or mental disability, sexual orientation, gender identity and/or expression, genetic information, pregnancy or pregnancy-related condition, military service, marital, parental, veteran status, or any other legally protected status in any and all educational programs or activities operated by Boston University. Retaliation is also prohibited. Please refer questions or concerns about Title IX, discrimination based on any other status protected by law or BU policy, or retaliation to Boston University’s Executive Director of Equal Opportunity/Title IX Coordinator, at titleix@bu.edu or (617) 358-1796. Read Boston University’s full Notice of Nondiscrimination.
Search
Boston University Masterplate
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
Profs Probe the Science of Sleep
0
share this