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Welcome to the Tolan Lab


We are interested in-

  • The biochemistry, enzymology, molecular human genetics, evolution, metabolomics involving the glycolytic enzyme aldolase
  • The structure and function of aldolases
  • The characterization of the genetic defects in hereditary fructose intolerance (HFI) and their metabolic consequences
  • The evolution of the aldolases and their moonlighting functions in the cell
  • The metabolic pathways involving the aldolase isozymes; in particular fructose metabolism



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