A hands-on class focusing on the mechanisms that control protein homoestasis, and on the approaches that we can use to study how it may change in conditions associated with neurodegenerative diseases. The class mimics, as much as possible, a real research environment, as students carry out experiments throughout the semester, learn how to develop and test new hypotheses, and also share knowledge through weekly readings and presentation of research articles inherent to the topics of the class. Effective Fall 2021, this course fulfills a single unit in each of the following BU Hub areas: Scientific Inquiry II, Creativity/Innovation, Research and Information Literacy.