Microorganisms are the most abundant form of life in the ocean. Fluorescence in situ hybridization (FISH) is a critical tool that uses sequencing to develop a deeper sense of specific microbe roles in an ecosystem. This project-based course weaves together scientific background, analytical tools, and data processing and analysis. Students gain insight into the complexity and importance of marine microbial communities. With lab-based FISH projects, students design and conduct an adaptive set of experiments. Through computational data analysis, students turn raw data into usable results. Effective Fall 2021, this course fulfills a single unit in each of the following BU Hub areas: Oral and/or Signed Communication, Research and Information Literacy.