Modern human genetics has evolved at a tremendous pace, with the promise of an affordable complete genome sequence for every individual just around the corner. While the raw information has increased exponentially, its translation to patient care has not kept pace. We will discuss exciting recent advances in human genetics and genomics, with illustrative examples of their translation into improvements in diagnosis and treatment of patients. We will also discuss ethical and societal challenges of this rapidly evolving field. Our course is aimed at first or second year Ph.D. students, and will be taught by faculty in a variety of departments through traditional lectures and discussion sections. Students will be evaluated on their ability to explain the translational research process and demonstrate how individual research findings build on one another to move a field forward to ultimately impact patient care.