Advanced course designed for those considering a clinical or research career in human genetics. Emphasis is on clinical cytogenetics (chromosome testing). Course will cover types of chromosome abnormalities, methodology, nomenclature and clinical significance in pregnancy, birth defects, and cancer. Laboratory work will include basic blood culture, chromosome preparation, banding, identification and karyotyping. Course will provide updated review of latest cytogenetic methodology and applications, such as FISH, comparative genomic hybridization (CGH) and array CGH lab.