The Center of Excellence in Sickle Cell Disease, directed by Elizabeth S. Klings M.D., supports the highest quality of patient care in an attempt to make Boston Medical Center (BMC) the treatment facility of choice for Boston-area patients with sickle cell disease. The Center also promotes interactive basic and clinical research and patient and professional educational activities.

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Components of the Center of Excellence in Sickle Cell Disease

The Basic and Translational Research Program in Sickle Cell Disease (BTRP)

Welcome to the Center of Excellence for Sickle Cell Disease

Welcome to the Center of Excellence in Sickle Cell Disease

  • Genetic modulation of fetal hemoglobin expression
  • The use of iPS cells to increase fetal hemoglobin expression
  • Mechanisms of hemoglobin switching
  • Sickle cell patient database and biological sample repository

The Patkin Sickle Cell Adult Clinic (Clinical) The adult sickle cell clinic is located in our newly opened Solomont Cancer Center. This unit is a state-of-the art facility where patients are seen daily by faculty within the Adult Hematology/Oncology section. There is an infusion center where acute pain episodes may be treated. Dr. Hedy Smith, Dr. Lillian McMahon and Charlene Sylvestre, NP, staff this clinic.

The Pediatric Sickle Cell Clinic (Clinical) The pediatric sickle cell program at Boston Medical Center provides state-of-the-art care to children and their families affected by all types of this disorder. With emphasis on prevention and maintenance of wellness, the pediatric program proudly reports extremely high rates of recommended vaccines administered, screening tests completed, and use of preventative medications such as penicillin and hydroxyurea by eligible patients. This team is co-led by Dr. Amy Sobota, MD, MPH and Dr. Caitlin Neri, MD, MPH.

Sickle cell inpatient services (Clinical) Inpatient services are available for adults and children. All inpatients with sickle cell disease are consulted on by experts in the management of this disease.

The Hemoglobin Diagnostic Reference Laboratory (Diagnostics) This laboratory, directed by Dr. David Chui, provides genetic testing for hemoglobinopathies, including antenatal diagnosis, throughout the US and many foreign countries.

Research projects (Research)  Current research projects at the Center focus on:

  1. The genetic modulation of sickle cell disease
  2. Fetal hemoglobin (HbF) regulation in sickle cell disease
  3. Sickle Cell related Lung Disease:  a) The biology and treatment of pulmonary hypertension in sickle cell disease  b) The effect of second-hand smoke on lung function in children and adolescents with sickle cell disease  c) The epidemiology of sleep-disordered breathing and its impact on endothelial dysfunction
  4. Development of new agents that modulate HbF expression in sickle cell disease
  5. Health services research targeting improving transition of care from pediatrics to adults
  6. Quality Improvement projects targeting clinical care at BMC
  7. Phase I, II, and III clinical trials
For further information, contact:
Elizabeth S. Klings, MD
Associate Professor of Medicine, Department of Medicine
Boston University School of Medicine
Program Director | Center of Excellence in Sickle Cell Disease
Director | Pulmonary Hypertension Inpatient and Education Program
Medical Director | Pulmonary Rehabilitation Program
Boston Medical Center
Email Klingon@bu.edu
Phone 617 638-8679
Fax 617 638-5227
Office Location 72 East Concord Street, R-304, Boston, MA  02118






updated 04/02/15