COMETS is a software platform for performing computer simulations of metabolism in spatially structured microbial communities. It is based on stoichiometric modeling of the genome-scale metabolic network of individual microbial species (using dynamic flux balance analysis), and on a discrete approximation of diffusion. For more information, see Harcombe et al., Metabolic Resource Allocation in Individual Microbes Determines Ecosystem Interactions and Spatial Dynamics, Cell Reports, 2014.

 

Download:

COMETS can be downloaded here.

Install and Run:

The instructions for installing and running COMETS are here.

User Manual:

How to start with COMETS and description of the layout and model files format is here.

Publications, Layouts and Models:

Examples of published layouts and models are here.

Software Development:

COMETS is open-source software. The code is available at: https://github.com/segrelab/comets. If you are interested in contributing to the development of COMETS, or have any questions about the code, please contact us:
comets@bu.edu