As part of a newly funded HFSP project, we are looking for students and postdocs to join an international team to work on interactions among globally abundant marine microbes using lab and field experiments, bioinformatics analyses and genome-scale metabolic modeling. See details here.
Antonio Gomes’ paper “Resource competition may lead to effective treatment of antibiotic resistant infections” has been published in PLOS ONE, and is available here.
Sara Baldwin Collins and Lina Faller successfully defended their Ph.D. dissertation in Bioinformatics, both presenting work on functional diversity in microbial communities. Congratulations!!!
Varun Mazumdar’s paper “Metabolic proximity in the order of colonization of a microbial community” has been published in PLOS ONE. The paper can be downloaded here.
A new PLOS Comp Bio paper by Ed Reznik, in collaboration with Pankaj Mehta, shows how the sensitivity of growth to violation of mass balance constraints in stoichiometric models can provide information on the variability of metabolite pools.
A Special Issue of FEBS Letters is celebrating “A century of Michaelis-Menten kinetics”. We contributed to this issue with a paper titled “The average enzyme principle”. Remember the term for the enzyme concentration, E, in the Michaelis-Menten equation? What if that term becomes E(t), i.e. it depends explicitly on time, for example due to regulation? We show that, over a given time interval, the net metabolite changes depend only on the time average of E(t). The theorem can be generalized to a network of synchronously regulated reactions.
Congratulation to Dr. Ed Reznik for graduating in BME, and winning a prize for best Ph.D. dissertation.