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James S. Panek Publications

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  • 169. Total Synthesis of (+)-Isatisine A: Jihoon Lee and James S. Panek. Org. Lett., 2011, 13, 502-505. [Link]

    Total Synthesis of (+)-Isatisine A

  • 168. Stereoselective C-Glycosidations with Achiral and Chiral Allenylsilanes: Ryan A. Brawn and James S. Panek. Org. Lett., 2010, 12, 4624-4627. [Link]

    Stereoselective C-Glycosidations with Achiral and Chiral Allenylsilanes

  • 167. Total Synthesis of (−)-Virginiamycin M2: Jie Wu and James S. Panek. Angew Chm. Int. Ed., 2010, 49, 6165-6168. [Link]

    Synercid (dalfopristin + quinupristin)

  • 166. Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90. Iwona E. Wrona, Alexander Gozman, Tony Taldone, Gabriela Chiosis and James S. Panek. J. Org. Chem., 2010, 75 (9), 2820–2835. [Link]

     Metal Mediated Reaction Methodology

  • 165. Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si−H Insertion: Jie Wu, Yu Chen and James S. Panek Org. Lett., 2010, 12 (9), 2112–211. [Link]

     Metal Mediated Reaction Methodology

  • 164. Regioselective Intramolecular Dipolar Cycloaddition of Azides and Unsymmetrical Alkynes: Ryan A. Brawn, Morgan Welzel, Jason T. Lowe and James S. Panek. Org. Lett., 2010, 12 (2), 336–339. [Link]
  • 163. Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90 Iwona E. Wrona, Alexander Gozman, Tony Taldone, Gabriela Chiosis and James S. Panek. J. Org. Chem., 2010, 75 (9), 2820–2835. [Link]
  • 162. Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si−H Insertion Jie Wu, Yu Chen and James S. Panek. Org. Lett., 2010, 12 (9), 2112–211. [Link]
  • 161. Regioselective Intramolecular Dipolar Cycloaddition of Azides and Unsymmetrical Alkynes Ryan A. Brawn, Morgan Welzel, Jason T. Lowe & James S. Panek. Org. Lett., 2010, 12 (2), 336–339. [Link]
  • 160.Total Synthesis of Brevisamide. Jihoon Lee and James S. Panek. Org. Lett. 2009, 11, 4390.
  • 159. Synthesis of Enantioenriched Homopropargylic Sulfonamides by a Three Component Reaction of Aldehydes, Sulfonamide, and Chiral Allenylsilanes. Ryan A. Brawn and James S. Panek. Org. Lett. 2009, 11, 4362.
  • 158. Steroocontrolled Synthesis of Spirooxindoles Through Lewis Acid Promoted [5 + 2]-Annulation of Chiral Silylalcohols. Yun Zhang and James S. Panek. Org. Lett. 2009, 11, 3366.
  • 157. Steroocontrolled Synthesis of Spirooxindoles Through Lewis Acid Promoted [5 + 2]-Annulation of Chiral Silylalcohols. Yun Zhang and James S. Panek. Org. Lett. 2009, 11, Submitted for publication.
  • 156. Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on Actin State, Cell Cycle and Tumor Cell Growth. Iwona E. Wrona, Jason T. Lowe, Thomas J. Turbyville, Tanya R. Johnson, Julien Beignet, John A. Beutler, and James S. Panek. J. Org. Chem. 2009, 74, 1897-1916.
  • 155. [3 + 2] Annulation of Enantioenriched Allenylsilanes with In Situ Generated Iminium Ions: Stereoselective Synthesis of Dihydropyrroles and Dihydrooxazines. Ryan Brawn and James S. Panek.. Org. Lett. 2009, 11, 473-476.
  • 154. Total Synthesis of (-)-Kendomycin. Jason T. Lowe, and James S. Panek. Org. Lett. 2008, 9, 3813.
  • 153. Total Synthesis of the HSP-90 Inhibitor Geldanamycin. Hua-Li Qin, James S. Panek. Org. Lett. 2008, 10, 2477.
  • 152. Design and Synthesis of Ansamycin Antibiotics. Iwona E. Wrona, Vangelis Agouridas, James S. Panek. Comptes-Rendus Académie des Sciences, Paris 2008, 11, 1483 – 1522.
  • 151. Total Synthesis and Stereochemical Reassignmant of (+)-Neopeltolide. Willmen Youngsaye, Jason T. Lowe, Frauke Pohlki, Paul Ralifo, and James S. Panek Angew. Chem. Int. Ed. 2007, 46, 9211-9214.
  • 150. Diversity Generation using Alkylidene Indane and Related Scaffolds. Sarathy Kesavan, James S. Panek and John A. Porco. Org. Lett. 2007, 9, 5203-5206.
  • 149. Skeletal Diversity through Radical Cyclization of Tetrahydropyridine Scaffolds. Sivaraman Dandapani, Mihai Duduta, James S. Panek and John A. Porco. J Org. Lett. 2007, 9, 3849.
  • 148. Nuclophilic Addition to N-Phosphinylimines by Rare-Earth–Metal Triflate/Trifluoroacetic Anhydride Activation. Winnie W. Ong, Aaron B. Beeler, Sarathy Kesavan, James S. Panek and John A. Porco. Angew. Chem. Int. Ed. 2007, 46, 7470-7472.
  • 147. Total Synthesis of Herboxidiene/GEX 1A. Yun Zhang and James S. Panek. J Org. Lett. 2007, 9, 3141 – 3143.
  • 146. Preparartion and Use of Enantioenriched Allenylsilanes for the Stereoselective Synthesis of Homopropargylic Ethers. Ryan A. Brawn, James S. Panek. J Org. Lett. 2007, 9, 2689-2692.
  • 145. Stereochemical and Skeletal Diversity Employing Pipecolic Ester Scaffolds. Yu Chen, John A. Porco, Jr., James S. Panek. Org. Lett. 2007, 9, 1529-1532.
  • 144. Total Synthesis of Bistramide A. J. T. Lowe, I. E. Wrona, J. S. Panek. Org. Lett. 2007, 9, 327-330.
  • 143. Reductive Opening of Aryl Pyranosides Promoted by Scandium(III) Triflate. H.-L. Qin, J. T. Lowe, James S. Panek. Am. Chem. Soc. 2007; 129(1); 38-39.
  • 142. [4 + 2]-Annulations of Chiral Organosilanes: Application to the Total Synthesis of Leucascandrolide A; Qibin Su, Les Dakin and James S. Panek. Org. Chem. 2007, 72 , 2- 24.
  • 141. Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GCPR Targets. Sivaraman Dandapani, Aaron B. Beeler, Ping Lan, Scott Beischel, Athier Abbas, Bryan R. Roth, John A. Porco, Jr. and James S. Panek. J Org. Chem. 2006 71 8934-8945.x
  • 140. A Convenient Multi-Gram Synthesis of Highly Enantioenriched Methyl 3-Silyl Glycidates. Jason T. Lowe, Willmen Youngsaye and James S. Panek. J. Org. Chem. 2006, 71, 3639.
  • 139. Total Synthesis of Reblastatin. Wrona, I. E.; Gabarda, A. E.; Evano, G.; Panek, J. S.; J. Am. Chem. Soc. 2005 , 127 , 15026-15027.
  • 138. Three-Component, Room Temperature Crotylation Catalyzed by Solid-Supported Br nsted Acid: Enantioselective Synthesis of Homoallylic Carbamates. Lipomi, D. J.; Panek, J. S. Org. Lett. 2005 , 7 , 4701-4704.
  • 137. Enantioselective Synthesis of Linear Polypropionate Arrays Using Anthracene-Tagged Organosilanes. Kesavan, S.; Su, Q.; Shao, J.; Porco, J. A., Jr.; Panek, J. S. Org. Lett. 2005 , 7 , 4435-4438.
  • 136. Synthesis of a Library of Complex Macrodiolides Employing Cyclodimerization of Hydroxy Esters Beeler. A. B.; Acquilano, D. E.; Su, Q.; Yan, F.; Roth, B. L.; Panek, J. S.; Porco, J. A., Jr. J. Comb. Chem. 2005 , 7 , 673-681.
  • 135. Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling. Su, Shun; Acquilano, Dayle E.; Arumugasamy, Jeevanandam; Beeler, Aaron B.; Eastwood, Erin L.; Giguere, Joshua R.; Lan, Ping; Lei, Xiaoguang; Min, Geanna K.; Yeager, Adam R.; Zhou, Ya; Panek, James S.; Snyder, John K.; Schaus, Scott E.; Porco, John A., Jr. Organic Letters (2005), 7(13), 2751-2754.
  • 135.1 Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling [Erratum for Volume 7, 2005]. Su, Shun; Acquilano, Dayle E.; Arumugasamy, Jeevanandam; Beeler, Aaron B.; Eastwood, Erin L.; Giguere, Joshua R.; Lan, Pin; Lei, Xiaguang; Min, Geanna K.; Yeager, Adam R.; Zhou, Ya; Panek, James S.; Snyder, John K.; Schaus, Scott E.; Porco, John A., Jr. Organic Letters (2005), 7(15), 3391.
  • 134. Crotylsilane Reagents in the Synthesis of Complex Polyketide Natural Products: Total Synthesis of (+)-Discodermolide. Arefolov, Alexander; Panek, James S. Journal of the American Chemical Society (2005), 127(15), 5596-5603.
  • 133. Stereocontrolled [4+2]-Annulation Accessing Dihydropyrans: Synthesis of the C1a-C10 Fragment of Kendomycin. Lowe, Jason T.; Panek, James S. Organic Letters (2005), 7(8), 1529-1532.
  • 132. Synthesis and [4 + 2]-Annulation of Enantioenriched (Z)-Crotylsilanes: Preparation of the C1-C13 Fragment of Bistramide A. Lowe, Jason T.; Panek, James S. Organic Letters (2005), 7(15), 3231-3234.
  • 131. Total synthesis of (+)-leucascandrolide A. Su, Qibin; Panek, James S. Angewandte Chemie, International Edition (2005), 44(8), 1223-1225.
  • 130. A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization. Evano, Gwilherm; Schaus, Jennifer V.; Panek, James S. Organic Letters (2004), 6(4), 525-528.
  • 129. Total Synthesis of (-)-Apicularen A. Su, Qibin; Panek, James S. Journal of the American Chemical Society (2004), 126(8), 2425-2430.
  • 128. Total Synthesis of (-)-Callystatin A. Langille, Neil F.; Panek, James S. Organic Letters (2004), 6(18), 3203-3206.
  • 127. Total Synthesis of Basiliskamides A and B. Lipomi, Darren J.; Langille, Neil F.; Panek, James S. Organic Letters (2004), 6(20), 3533-3536.
  • 126. Total Synthesis of Callipeltoside A. Huang, Hongbing; Panek, James S. Organic Letters (2004), 6(23), 4383-4385.
  • 125. Total Synthesis of Cystothiazoles A and B. Shao, Jian; Panek, James S. Organic Letters (2004), 6(18), 3083-3085
  • 124. Total Synthesis of Herbimycin A. Carter, Kendra D.; Panek, James S. Organic Letters (2004), 6(1), 55-57.
  • 123. A Mild, Chemoselective Protocol for the Removal of Thioketals and Thioacetals Mediated by Dess-Martin Periodinane. Langille, Neil F.; Dakin, Les A.; Panek, James S. Organic Letters (2003), 5(4), 575-578.
  • 122. Enantioselective [4 + 2]-Annulation of Chiral Crotylsilanes: Application to the Synthesis of a C1-C22 Fragment of Leucascandrolide A. Dakin, Les A.; Panek, James S. Organic Letters (2003), 5(21), 3995-3998.
  • 121. Highly Enantioenriched Tetrahydropyridines from Chiral Organosilanes: Application to the Synthesis of Quinolizidine Alkaloid (-)-217A. Huang, Hongbing; Spande, Thomas F.; Panek, James S. Journal of the American Chemical Society (2003), 125(3), 626-627.
  • 120. Organosilanes in Synthesis: Application to an Enantioselective Synthesis of Methyl-L-callipeltose. Huang, Hongbing; Panek, James S. Organic Letters (2003), 5(11), 1991-1993.
  • 119. Stereochemical Diversity through Cyclodimerization: Synthesis of Polyketide-like Macrodiolides. Su, Qibin; Beeler, Aaron B.; Lobkovsky, Emil; Porco, John A.; Panek, James S. Organic Letters (2003), 5(12), 2149-2152.
  • 118. Asymmetric Crotylation Reactions in Synthesis of Polypropionate-Derived Macrolides: Application to Total Synthesis of Oleandolide. Hu, Tao; Takenaka, Norito; Panek, James S. Journal of the American Chemical Society (2002), 124(43), 12806-12815.
  • 117. Asymmetric synthesis of a C1-C19 fragment of ulapualide A. Celatka, Cassandra A.; Panek, James S. Tetrahedron Letters (2002), 43(39), 7043-7046.
  • 116. Enantioselective Synthesis of the Protein Phosphatase Inhibitor (-)-Motuporin. Hu, Tao; Panek, James S. Journal of the American Chemical Society (2002), 124(38), 11368-11378.
  • 115. Sonogashira Coupling of Functionalized Trifloyl Oxazoles and Thiazoles with Terminal Alkynes: Synthesis of Disubstituted Heterocycles. Langille, Neil F.; Dakin, Les A.; Panek, James S. Organic Letters (2002), 4(15), 2485-2488.
  • 114. Stereoselective Additions of Chiral (E)-Crotylsilanes to Thionium Ions: Asymmetric Synthesis of Homoallylic Thioethers. Liu, Ping; Binnun, Eva D.; Schaus, Jennifer V.; Valentino, Nicole M.; Panek, James S. Journal of Organic Chemistry (2002), 67(5), 1705-1707.
  • 113. Studies Directed toward the Total Synthesis of Discodermolide: Asymmetric Synthesis of the C1-C14 Fragment. Arefolov, Alexander; Panek, James S. Organic Letters (2002), 4(14), 2397-2400.
  • 112. Synthesis of the C1′-C11′ Oxazole-Containing Side Chain of Leucascandrolide A. Application of a Sonogashira Cross-Coupling. Dakin, Les A.; Langille, Neil F.; Panek, James S. Journal of Organic Chemistry (2002), 67(19), 6812-6815.
  • 111. Enhanced diastereoselectivity in asymmetric crotylation reactions using propargylic dicobalt hexacarbonyl complexes. Sui, Meng; Panek, James S. Organic Letters (2001), 3(16), 2439-2442.
  • 110. Formal [4 + 2]-Annulation of Chiral Crotylsilanes: Synthesis of the C19-C28 Fragment of Phorboxazoles. Huang, Hongbing; Panek, James S. Organic Letters (2001), 3(11), 1693-1696.
  • 109. Methodology based on chiral silanes in the synthesis of polypropionate-derived natural products – total synthesis of epothilone A. Zhu, Bin; Panek, James S. European Journal of Organic Chemistry (2001), (9), 1701-1714.
  • 108. Stereoselective Synthesis of Functionalized Trisubstituted Olefins via Palladium(0)-Catalyzed Cross-Coupling Reaction. Arefolov, Alexander; Langille, Neil F.; Panek, James S. Organic Letters (2001), 3(21), 3281-3284.
  • 107. Total Synthesis of Rutamycin B and Oligomycin C. Panek, James S.; Jain, Nareshkumar F.
    • Journal of Organic Chemistry (2001), 66(8), 2747-2756.
  • 106. An Asymmetric Aminohydroxylation Approach to the Azepine Core of (-)-Balanol. Masse, Craig E.; Morgan, Adam J.; Panek, James S. Organic Letters (2000), 2(17), 2571-2573.
  • 105. Asymmetric synthesis of homoallylic amines and functionalized pyrrolidines via direct amino-crotylation of in situ generated imines. Schaus, Jennifer V.; Jain, Nareshkumar; Panek, James S. Tetrahedron (2000), 56(52), 10263-10274.
  • 104. Enzymatic resolution of thiazole-containing vinyl carbinols. Synthesis of the C12-C21 fragment of the epothilones. Zhu, Bin; Panek, James S. Tetrahedron Letters (2000), 41(12), 1863-1866.
  • 103. Palladium-Catalyzed Cross-Coupling of Terminal Alkynes with 4-Trifloyloxazole: Studies toward the Construction of the C26-C31 Subunit of Phorboxazole A. Schaus, Jennifer V.; Panek, James S. Organic Letters (2000), 2(4), 469-471.
  • 102. Speciation and Mechanistic Studies of Chiral Copper(I) Schiff Base Precursors Mediating Asymmetric Carbenoid Insertion Reactions of Diazoacetates into the Si-H Bond of Silanes. Dakin, Les A.; Ong, Patricia C.; Panek, James S.; Staples, Richard J.; Stavropoulos, Pericles. Organometallics (2000), 19(15), 2896-2908.
  • 101. Stereoselective Synthesis of Functionalized Dihydropyrans via a Formal [4+2]-Annulation of Chiral Crotylsilanes. Huang, Hongbing; Panek, James S. Journal of the American Chemical Society (2000), 122(40), 9836-9837.
  • 100. Syntheses and biological evaluation of (+)-lactacystin and analogs. Masse, Craig E.; Morgan, Adam J.; Adams, Julian; Panek, James S. European Journal of Organic Chemistry (2000), (14), 2513-2528.
  • 100.1. Synthesis and antibacterial activity of myxopyronins and intermediates. Wuonola, Mark A.; Gustafson, Gary R.; Panek, James S.; Hu, Tao; Schaus, Jennifer V. (Scriptgen Pharmaceuticals, Inc., USA ; Trustees of Boston University ). U.S. (2000), 52 pp., Cont.-in-part of U.S. 822,323.
  • 99. Total Synthesis of (-)-Mycalolide A. Liu, Ping; Panek, James S. Journal of the American Chemical Society (2000), 122(6), 1235-1236.
  • 98. Total Synthesis of Epothilone A. Zhu, Bin; Panek, James S. Organic Letters (2000), 2(17), 2575-2578.
  • 97. Total Synthesis of the Actin-Depolymerizing Agent (-)-Mycalolide A: Application of Chiral Silane-Based Bond Construction Methodology. Panek, James S.; Liu, Ping. Journal of the American Chemical Society (2000), 122(45), 11090-11097.
  • 96. A new method for generating Sn-H bonds: reactions of tin amides with silicon hydrides. Schaus, Jennifer V.; Panek, James S. Chemtracts (1999), 12(4), 264-266.
  • 95. Absolute stereochemistry of mycalolides, bioactive macrolides from the marine sponge mycale magellanica. Matsunaga, Shigeki; Fusetani, Nobuhiro; Liu, Ping; Celatka, Cassandra A.; Panek, James S. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1999), 41st 253-258.
  • 94. Relative and Absolute Stereochemistry of Mycalolides, Bioactive Macrolides from the Marine Sponge Mycale magellanica. Matsunaga, Shigeki; Liu, Ping; Celatka, Cassandra A.; Panek, James S.; Fusetani, Nobuhiro. Journal of the American Chemical Society (1999), 121(23), 5605-5606.
  • 94.1 Relative and Absolute Stereochemistry of Mycalolides, Bioactive Macrolides from the Marine Sponge Mycale magellanica. [Erratum to document cited in CA131:170209]. Matsunaga, Shigeki; Liu, Ping; Celatka, Cassandra A.; Panek, James S.; Fusetani, Nobuhiro. Journal of the American Chemical Society (1999), 121(38), 8969.
  • 93. Reversal of regioselection in the Sharpless asymmetric aminohydroxylation of aryl ester substrates. Morgan, Adam J.; Masse, Craig E.; Panek, James S. Organic Letters (1999), 1(12), 1949-1952.
  • *Synthesis of pyronins and intermediates for use as antibacterials. Wuonola, Mark A.; Gustafson, Gary; Panek, James S.; Hu, Tao; Schaus, Jennifer V. (Scriptgen Pharmaceuticals, Inc., USA ; Trustees of Boston University ). PCT Int. Appl. (1999), 92 pp.
  • 92. Total synthesis of (+)-lactacystin. Panek, James S.; Masse, Craig E. Angewandte Chemie, International Edition (1999), 38(8), 1093-1095.
  • 91. Total synthesis of (-)-Motuporin. Hu, Tao; Panek, James S. Journal of Organic Chemistry (1999), 64(9), 3000-3001.
  • 90. Total Synthesis of Oleandolide. Hu, Tao; Takenaka, Norito; Panek, James S. Journal of the American Chemical Society (1999), 121(39), 9229-9230.
  • 89. Advances in Asymmetric Synthesis, Vol. 2. Edited by Alfred Hassner ( Bar-Ilan University ). Panek, James S.; Masse, Craig E. Journal of the American Chemical Society (1998), 120(12), 2992.
  • 88. An Improved Synthesis of (4S,5S)-2-Phenyl-4-(methoxycarbonyl)-5-isopropyloxazoline from (S)-Phenylglycinol. Panek, James S.; Masse, Craig E. Journal of Organic Chemistry (1998), 63(7), 2382-2384.
  • 88.1 An Improved Synthesis of (4S,5S)-2-Phenyl-4-methoxycarbonyl-5-isopropyloxazoline from (S)-Phenylglycinol. [Erratum to document cited in CA128:230279]. Panek, James S.; Masse, Craig E. Journal of Organic Chemistry (1998), 63(15), 5294.
  • 87. Carbenoid insertions into the silicon-hydrogen bond catalyzed by chiral copper(I) schiff base complexes. Dakin, Les A.; Schaus, Scott E.; Jacobsen, Eric N.; Panek, James S.. Tetrahedron Letters (1998), 39(49), 8947-8950.
  • 86. Chiral Crotylsilane-Based Approach to Benzoquinoid Ansamycins: Total Synthesis of (+)-Macbecin I. Panek, James S.; Xu, Feng; Rondon, Ana C. Journal of the American Chemical Society (1998), 120(17), 4113-4122.
  • 85. Chiral magnesium bis(sulfonamide) complexes as catalysts for the merged enolization and enantioselective amination of N-acyloxazolidinones. A catalytic approach to the synthesis of arylglycines. Celatka, Cassandra A.; Panek, James S. Chemtracts (1998), 11(11), 836-839.
  • 84. Recent advances in catalytic asymmetric epoxidation of trisubstituted and trans-olefins. Dakin, Les. A.; Panek, James S. Chemtracts (1998), 11(7), 531-536.
  • 83. Studies directed toward the total synthesis of kabiramide C: asymmetric synthesis of the C1-C19 fragment. Liu, Ping; Panek, James S. Tetrahedron Letters (1998), 39(34), 6147-6150.
  • 82. Studies directed toward the total synthesis of kabiramide C: asymmetric synthesis of the C7-C19 fragment. Liu, Ping; Panek, James S. Tetrahedron Letters (1998), 39(34), 6143-6146.
  • *Synthesis of aromatic compounds by Diels-Alder reaction on solid support. Panek, James S.; Zhu, Bin. (Trustees of Boston University , USA ). PCT Int. Appl. (1998), 26 pp.
  • 81. Total Synthesis and Preliminary Antibacterial Evaluation of the RNA Polymerase Inhibitors ( ± )-Myxopyronin A and B. Hu, Tao; Schaus, Jennifer V.; Lam, Kelvin; Palfreyman, Michael G.; Wuonola, Mark; Gustafson, Gary; Panek, James S. Journal of Organic Chemistry (1998), 63(7), 2401-2406.
  • 80. Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I: Application of Asymmetric Crotylsilane Bond Constructions. Masse, Craig E.; Yang, Michael; Solomon, Jason; Panek, James S. Journal of the American Chemical Society (1998), 120(17), 4123-4134.
  • 79. Total Synthesis of Oligomycin C. Panek, James S.; Jain, Nareshkumar F. Journal of Organic Chemistry (1998), 63(14), 4572-4573.
  • 78. Application of chiral (E)-crotylsilanes in synthesis: the asymmetric synthesis of the C1-C17 polypropionate fragment of rutamycin B. Jain, Nareshkumar F.; Panek, James S. Tetrahedron Letters (1997), 38(8), 1345-1348.
  • 77. Application of chiral (E)-crotylsilanes in synthesis: the asymmetric synthesis of the C19-C34 spiroketal fragment of rutamycin B. Jain, Nareshkumar F.; Panek, James S. Tetrahedron Letters (1997), 38(8), 1349-1352.
  • 76. Asymmetric C-N Bond Constructions via Crotylsilane Addition Reactions: A Stereocontrolled Route to Dipeptide Isosteres. Masse, Craig E.; Knight, Bradford S.; Stavropoulos, Pericles; Panek, James S. Journal of the American Chemical Society (1997), 119(26), 6040-6047.
  • 75. Asymmetric Crotylation Reactions on Solid Support: Synthesis of Stereochemically Well-Defined Polypropionate-Like Subunits. Panek, James S.; Zhu, Bin. Journal of the American Chemical Society (1997), 119(49), 12022-12023.
  • 74. Asymmetric synthesis of (2S,3S,8S,9S)-N-Boc ADDA: Application of a palladium(0)-catalyzed cross-coupling reaction of trisubstituted olefins. Panek, James S.; Hu, Tao. Journal of Organic Chemistry (1997), 62(15), 4914-4915.
  • 73. Double stereodifferentiating crotylation reactions with a -amino aldehydes: asymmetric synthesis of vicinal amino alcohol synthons. Panek, James S.; Liu, Ping. Tetrahedron Letters (1997), 38(29), 5127-5130.
  • 72. Double stereodifferentiation in the Lewis acid promoted C-glycosidation of activated glycals with chiral (E)-crotylsilanes. Panek, James S.; Schaus, Jennifer V. Tetrahedron (1997), 53(32), 10971-10982.
  • 71. Kinetic resolution of terminal epoxides via highly regioselective and enantioselective ring opening with TMSN3. An efficient, catalytic route to 1,2-amino alcohols. Rondon, Ana C.; Panek, James S. Chemtracts (1997), 10(14), 1058-1061.70.
  • 70. Lewis acid-mediated carbocyclization reactions of chiral (E)-crotylsilanes. Masse, Craig E.; Dakin, Les A.; Knight, Bradford S.; Panek, James S. Journal of Organic Chemistry (1997), 62(26), 9335-9338.
  • *Preparation of pyronin antibacterials and their novel intermediates. Wuonola, Mark A.; Gustafson, Gary R.; Panek, James S.; Hu, Tao; Schaus, Jennifer V. (Scriptgen Pharmaceuticals, Inc., USA ; Trustees of Boston University). PCT Int. Appl. (1997), 111 pp.
  • 69. Stereo- and regiocontrolled synthesis of branched trisubstituted conjugated dienes by palladium(0)-catalyzed cross-coupling reactions. Panek, James S.; Hu, Tao. Journal of Organic Chemistry (1997), 62(15), 4912-4913.
  • 68. Studies directed toward the synthesis of ulapualide A: phosphorus-based olefination as model studies for (Schlosser-like) fragment coupling. Celatka, Cassandra A.; Liu, Ping; Panek, James S. Tetrahedron Letters (1997), 38(31), 5449-5452.
  • 67. Synthesis of the fully functionalized tris-oxazole fragment found in metabolites derived from marine organisms. Liu, Ping; Celatka, Cassandra A.; Panek, James S. Tetrahedron Letters (1997), 38(31), 5445-5448.
  • 66. Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I. Panek, James S.; Masse, Craig E. Journal of Organic Chemistry (1997), 62(24), 8290-8291.
  • 65. Double-Stereodifferentiating Crotylation Reactions with Chiral (E)-Crotylsilanes. Evaluation of a New Approach for the Synthesis of Polypropionate-Derived Natural Products. Jain, Nareshkumar F.; Takenaka, Norito; Panek, James S. Journal of the American Chemical Society (1996), 118(49), 12475-12476.
  • 64. Studies Directed toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C26-C42 Fragment. Panek, James S.; Beresis, Richard T.; Celatka, Cassandra A. Journal of Organic Chemistry (1996), 61(19), 6494-6495.
  • 63. Studies Directed toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C8-C25 Tris-Oxazole Fragment. Panek, James S.; Beresis, Richard T. Journal of Organic Chemistry (1996), 61(19), 6496-6497.
  • 62. Synthesis of aromatic 1,2-diazines by inverse electron demand Diels-Alder reaction of polymer-supported 1,2,4,5-tetrazines. Panek, James S.; Zhu, Bin. Tetrahedron Letters (1996), 37(45), 8151-8154.
  • 61. An efficient procedure for the preparation of chiral b -substituted (E)-crotylsilanes: application of a rhodium(II) catalyzed silylformylation of terminal alkynes. Jain, Nareshkumar F.; Cirillo, Pier F.; Schaus, Jennifer V.; Panek, James S. Tetrahedron Letters (1995), 36(48), 8723-6.
  • 60. Development and utility of an enantioselective Ireland-Claisen reaction. Panek, James S.; Schaus, Scott; Masse, Craig E. Chemtracts: Organic Chemistry (1995), 8(4), 238-41.
  • 59. Development and utility of chiral Lewis acids for an asymmetric Claisen rearrangement. Masse, Craig E.; Panek, James S. Chemtracts: Organic Chemistry (1995), 8(4), 242-5.
  • 58. Diastereoselective Reactions of Chiral Allyl and Allenyl Silanes with Activated C:X p -Bonds. Masse, Craig E.; Panek, James S. Chemical Reviews (Washington, D. C.) (1995), 95(5), 1293-316.
  • 57. Double stereodifferentiation in the Lewis acid promoted crotylation of (S)-2-alkoxypropanal with chiral b -alkyl (E)-crotylsilanes. Jain, Nareshkumar F.; Cirillo, Pier F.; Pelletier, Roberta; Panek, James S. Tetrahedron Letters (1995), 36(48), 8727-30.
  • 56. Enantioselective Nitration of Chiral (E)-Crotylsilanes: A Concise Asymmetric Synthesis of (E)-Olefin Dipeptide Isosteres. Beresis, Richard T.; Masse, Craig E.; Panek, James S. Journal of Organic Chemistry (1995), 60(24), 7714-15.
  • 55. Studies directed toward the synthesis of (+)- mycotrienin I. Asymmetric synthesis of the C9-N21 aromatic synthon. Panek, James S.; Yang, Michael; Solomon, Jason. Tetrahedron Letters (1995), 36(7), 1003-6.
  • 54. Total Synthesis of (+)-Macbecin I. Panek, James S.; Xu, Feng. Journal of the American Chemical Society (1995), 117(42), 10587-8.
  • 53. Diastereoselectivity in cyclopropanation and epoxidation reactions of chiral (E)-crotylsilanes: asymmetric synthesis of substituted tetrahydrofurans. Panek, James S.; Garbaccio, Robert M.; Jain, Nareshkumar F. Tetrahedron Letters (1994), 35(35), 6453-6.
  • 52. Direct Amino-Crotylsilylation of Achiral Acetals and Aldehydes: Asymmetric Synthesis of Homoallylic Amines and Functionalized Pyrrolidines. Panek, James S.; Jain, Nareshkumar F. Journal of Organic Chemistry (1994), 59(10), 2674-5.
  • 51. Studies directed toward the synthesis of (+)-sesbanimide A: construction of the AB-ring system (a formal total synthesis). Cirillo, Pier F.; Panek, James S. Journal of Organic Chemistry (1994), 59(11), 3055-63.
  • 50. A concise enantioselective synthesis of trans-olefin dipeptide isosteres. Beresis, Richard; Panek, James S. Bioorganic & Medicinal Chemistry Letters (1993), 3(8), 1609-14.
  • 49. A general, catalytic and enantioselective synthesis of a -amino and a -hydroxy acids. Yang, Michael; Panek, James S. Chemtracts: Organic Chemistry (1993), 6(2), 79-82.
  • 48. Acyclic diastereoselectivity in the Lewis acid promoted additions of chiral, b -methyl-substituted (E)-crotylsilanes with achiral aldehydes. Panek, James S.; Cirillo, Pier F. Journal of Organic Chemistry (1993), 58(5), 999-1002.
  • 47. Asymmetric [3 + 2] D 2-isoxazoline annulation by electrophilic substitution of (E)-crotylsilanes with nitrosium tetrafluoroborate. Panek, James S.; Beresis, Richard T. Journal of the American Chemical Society (1993), 115(17), 7898-9.
  • 46. Conjugate addition reactions of chiral (E)-crotylsilanes: application to an asymmetric [3 + 2] cyclopentane annulation. Panek, James S.; Jain, Nareshkumar F. Journal of Organic Chemistry (1993), 58(9), 2345-8.
  • 45. Diastereoselectivity in the osmium tetraoxide promoted dihydroxylation of chiral (E)-crotylsilane: asymmetric synthesis of silyl-functionalized g -lactones. Panek, James S.; Zhang, Jing. Journal of Organic Chemistry (1993), 58(2), 294-6.
  • 44. Double stereodifferentiation in the Lewis acid-promoted addition of chiral (E)-crotylsilanes with (S)-2-(benzyloxy)propanal. Effect of Lewis acid on reaction diastereoselection. Panek, James S.; Beresis, Richard. Journal of Organic Chemistry (1993), 58(4), 809-11.
  • 43. Sequential diastereoselective addition and palladium(II)-catalyzed allylic acetate transposition of syn- and anti- a -acetoxy- b -silyl-(E)-hex-4-enoates with achiral acetals. Asymmetric synthesis of differentiated syn and anti 1,3-diol synthons. Panek, James S.; Yang, Michael; Solomon, Jason S. Journal of Organic Chemistry (1993), 58(5), 1003-10.
  • 42. Diastereoselective additions of chiral (E)-crotylsilanes to in situ generated oxonium ions: a direct asymmetric synthesis of functionalized homoallylic ethers. Panek, James S.; Yang, Michael; Xu, Feng. Journal of Organic Chemistry (1992), 57(21), 5790-2.
  • 41. Diastereoselectivity in the borane methyl sulfide promoted hydroboration of a -alkoxy- b , g -unsaturated esters. Documentation of an alkoxy-directed hydroboration reaction. Panek, James S.; Xu, Feng. Journal of Organic Chemistry (1992), 57(20), 5288-90.
  • 40. Directed reductions of b -hydroxy ketones by catecholborane. Diastereoselective synthesis of syn-1,3-diols. Panek, James S. Chemtracts: Organic Chemistry (1992), 5(3), 193-6.
  • 39. Directed reductions of b -hydroxy ketones employing tetramethylammonium triacetoxyborohydride. Diastereoselective synthesis of anti-1,3-diols. Panek, James S. Chemtracts: Organic Chemistry (1992), 5(3), 188-92.
  • 38. Ireland-Claisen rearrangements of chiral (Z)-vinylsilanes. Highly diastereoselective synthesis of anti- a -alkoxy- b -(dimethylphenylsilyl)-(E)-hex-4-enoates. Panek, James S.; Clark, Thomas D. Journal of Organic Chemistry (1992), 57(15), 4323-6.
  • 37. Preparation and Diels-Alder reaction of a reactive, electron-deficient heterocyclic azadiene: dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. 1,2-Diazine and pyrrole introduction. Boger, Dale L.; Panek, James S.; Patel, Mona. Organic Syntheses (1992), 70 79-92.
  • 36. Recent progress in the chemistry of acylsilanes. A review. Cirillo, Pier F.; Panek, James S. Organic Preparations and Procedures International (1992), 24(5), 553-82.
  • 35. Sequential diastereoselective addition and allylic azide isomerization of syn- and anti- a -azido- b -(dimethylphenylsilyl)-(E)-hex-4-enoates with acetals: asymmetric synthesis of g -hydroxy- a -amino acid synthons. Panek, James S.; Yang, Michael; Muler, Itzhak. Journal of Organic Chemistry (1992), 57(15), 4063-4.
  • 34. Claisen rearrangements of enantiomerically pure C3-(acyloxy)-(E)-vinylsilanes. Sparks, Michelle A.; Panek, James S. Journal of Organic Chemistry (1991), 56(10), 3431-8.
  • 33. Diastereofacial selectivity with optically active a -substituted b -silyl-(E)-hexenoates. Enantioselective construction of homoallylic ethers via reaction with aryl acetals. Panek, James S.; Yang, Michael. Journal of the American Chemical Society (1991), 113(17), 6594-600.
  • 32. Diastereoselective additions of chiral (E)-crotylsilanes to a -alkoxy and b -alkoxy aldehydes. A one-step, silicon-directed tetrahydrofuran synthesis. Panek, James S.; Yang, Michael. Journal of the American Chemical Society (1991), 113(26), 9868-70.
  • 31. Diastereoselective electrophilic addition reactions to chiral b -dimethylphenylsilyl ester enolates. Synthesis of 2,3-anti- a -substituted- b -silyl-(E)-hex-4-enoates. Panek, James S.; Beresis, Richard; Xu, Feng; Yang, Michael. Journal of Organic Chemistry (1991), 56(26), 7341-4.
  • 30. Lipase mediated resolution of chiral (E)-vinylsilanes: an improved procedure for the production of (R)- and (S)-(E)-1-(trialkylsilyl)-1-buten-3-ol derivatives. Sparks, Michelle A.; Panek, James S. Tetrahedron Letters (1991), 32(33), 4085-8.
  • 29. Palladium-catalyzed hydrogenolysis of acyldimethylphenylsilanes to aldehydes. Cirillo, Pier F.; Panek, James S. Tetrahedron Letters (1991), 32(4), 457-60.
  • 28. Remote asymmetric induction in diastereoface selective addition reactions of optically active a -substituted- b -silyl (E)-hexenoates with achiral a -alkoxy and b -alkoxy acetals. Panek, James S.; Yang, Michael. Journal of Organic Chemistry (1991), 56(20), 5755-8.
  • 27. p -Facial selectivity in catalytic osmylation reactions of chiral C1-oxygenated allylic silanes. Panek, James S.; Cirillo, Pier F. Journal of the American Chemical Society (1990), 112(12), 4873-8.
  • 26. Addition of carbenium ions to allylsilanes: interpretation of kinetic data via the quantitative analysis of ligand effects. Panek, James S.; Prock, Alfred; Eriks, Klaas; Giering, Warren P. Organometallics (1990), 9(7), 2175-6.
  • 25. Allylic transpositions of homochiral C-1-acyloxy E-crotyl silanes: stereospecific synthesis of E-vinylsilanes. Panek, James S.; Sparks, Michelle A. Journal of Organic Chemistry (1990), 55(21), 5564-6.
  • 24. Diastereoselectivity in nucleophilic addition reactions to ( a , b -dialkoxyacyl) silanes: an operationally useful route to optically active 1,2,3-syn-triols. Cirillo, Pier F.; Panek, James S. Journal of Organic Chemistry (1990), 55(25), 6071-3.
  • 23. Synthesis, resolution and absolute stereochemical assignment of C1-oxygenated allylsilanes and C3-oxygenated vinylsilanes. Panek, James S.; Sparks, Michelle A. Tetrahedron: Asymmetry (1990), 1(11), 801-16.
  • 22. Oxygenated allylic silanes: useful homoenolate equivalents for the stereoselective C-glycosidation of pyranoside derivatives. Panek, James S.; Sparks, Michelle A. Journal of Organic Chemistry (1989), 54(9), 2034-8.
  • 21. Use of 1JC1, H1 values for the stereochemical determination of C-glycosides: a simple two dimensional NMR protocol. Sparks, Michelle A.; Panek, James S. Tetrahedron Letters (1989), 30(4), 407-10.
  • 20. Preparation and inverse-electron-demand Diels-Alder reaction of an electron-deficient heterocyclic azadiene: triethyl 1,2,4-triazine-3,5,6-tricarboxylate. Boger, Dale L.; Panek, James S.; Yasuda, Masami. Organic Syntheses (1988), 66 142-50.
  • 19. Stereoselective glycosidation reactions of activated glycals with a C1-oxygenated allylsilane: synthesis of a cis-pyrano[2,3-b]pyran. Panek, James S.; Sparks, Michelle A. Tetrahedron Letters (1988), 29(36), 4517-20.
  • 18. Syn selective aldol reactions of titanium and zirconium dienolates. Panek, James S.; Bula, Oleh A. Tetrahedron Letters (1988), 29(14), 1661-4.
  • 17. Fluoride ion-mediated conjugate addition reactions of 1-(acyloxy)-2-propenyltrimethylsilane. Synthesis of 3-[1-(acyloxy)-2-propenyl]alkanones. Panek, James S.; Sparks, Michelle A. Tetrahedron Letters (1987), 28(40), 4649-52.
  • 16. Total synthesis of ( ± )-3-demethoxyerythratidinone: demonstration of a radical cyclization route to a site specific enol derivative. Danishefsky, Samuel J.; Panek, James S. Journal of the American Chemical Society (1987), 109(3), 917-18.
  • 15. A detailed, convenient preparation of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. Boger, Dale L.; Coleman, Robert S.; Panek, James S.; Huber, F. X.; Sauer, J. Journal of Organic Chemistry (1985), 50(25), 5377-9.
  • 14. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes. Studies on the total synthesis of lavendamycin: investigative studies on the preparation of the CDE b -carboline ring system and AB quinoline-5,8-quinone ring system. Boger, Dale L.; Duff, Steven R.; Panek, James S.; Yasuda, Masami. Journal of Organic Chemistry (1985), 50(26), 5782-9.
  • 13. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes: formal total synthesis of streptonigrin. Boger, Dale L.; Panek, James S.; Duff, Steven R. Journal of the American Chemical Society (1985), 107(20), 5745-54.
  • 12. Total synthesis of lavendamycin methyl ester. Boger, Dale L.; Duff, Steven R.; Panek, James S.; Yasuda, Masami. Journal of Organic Chemistry (1985), 50(26), 5790-5.
  • 11. Direct introduction of nitriles via use of unstable Reissert intermediates: convenient procedures for the preparation of 2-cyanoquinolines and 1-cyanoisoquinolines. Boger, Dale L.; Brotherton, Christine E.; Panek, James S.; Yohannes, Daniel. Journal of Organic Chemistry (1984), 49(21), 4056-8.
  • 10. Palladium(0)-mediated b -carboline synthesis: preparation of the CDE ring system of lavendamycin. Boger, Dale L.; Panek, James S. Tetrahedron Letters (1984), 25(30), 3175-8.
  • 9. Thermal cycloaddition of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with electron-rich olefins: 1,2-diazine and pyrrole introduction. Preparation of octamethylporphin (OMP). Boger, Dale L.; Coleman, Robert S.; Panek, James S.; Yohannes, Daniel. Journal of Organic Chemistry (1984), 49(23), 4405-9.
  • 8. 1,2,4-Triazine preparation via thermal cycloaddition of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with aryl thioimidates. Boger, Dale L.; Panek, James S. Tetrahedron Letters (1983), 24(42), 4511-14.
  • 7. Formal total synthesis of streptonigrin. Boger, Dale L.; Panek, James S. Journal of Organic Chemistry (1983), 48(4), 621-3.
  • 6. Diels-Alder reaction of heterocyclic azadienes. 2. “Catalytic” Diels-Alder reaction of in situ generated enamines with 1,2,4-triazines: general pyridine annulation. Boger, Dale L.; Panek, James S.; Meier, Michael M. Journal of Organic Chemistry (1982), 47(5), 895-7.
  • 5. Pyridine construction via thermal cycloaddition of 1,2,4-triazines with enamines: studies on the preparation of the biaryl CD rings of streptonigrin. Boger, Dale L.; Panek, James S. Journal of Organic Chemistry (1982), 47(19), 3763-5.
  • 4. Thermal cycloaddition of 1,3,5-triazine with enamines: regiospecific pyrimidine annulation. Boger, Dale L.; Schumacher, Jane; Mullican, Michael D.; Patel, Mona; Panek, James S. Journal of Organic Chemistry (1982), 47(13), 2673-5.
  • 3. Diels-Alder reaction of heterocyclic azadienes. I. Thermal cycloaddition of 1,2,4-triazine with enamines: simple preparation of substituted pyridines. Boger, Dale L.; Panek, James S. Journal of Organic Chemistry (1981), 46(10), 2179-82.
  • 2. Palladium(II) catalyzed coupling reactions of polyuridylic acid and uridylyl(3′ ® 5′)uridine with styrene and 3-nitrostyrene. Bigge, Christopher F.; Lizotte, Kathryn E.; Panek, James S.; Mertes, Mathias P. Journal of Carbohydrates, Nucleosides, Nucleotides (1981), 8(4), 295-313.
  • 1. Preparation of (R)-(+)- and (S)-(-)-4-iodo-1,2-epoxybutane [(R)- and (S)-(2-iodoethyl)oxirane], useful chiral synthons. Boger, Dale L.; Panek, James S. Journal of Organic Chemistry (1981), 46(6), 1208-10.