Tom Tullius

Professor of Chemistry

  • Title Professor of Chemistry
  • Education Ph.D., Stanford University

The aim of the Tullius lab is to understand how the structures of DNA and RNA influence biological function. We have developed a chemistry-based structural method that is well suited for this aim. This method takes advantage of the sensitivity of a highly reactive free radical, the hydroxyl radical, to local nucleic acid structure. This chemical probe method is ideal for the purpose of characterizing the tertiary structures of DNA and RNA molecules in solution. The advent of high-throughput sequencing technology has now made it possible for a single experiment to produce structural information for large collections of nucleic acid molecules in parallel. A project in the Tullius lab focuses on developing a high-throughput version of the hydroxyl radical cleavage experiment, with the aim of mapping RNA tertiary structure transcriptome-wide.

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