Clarissa Santoso publishes paper in Nucleic Acids Research

MCBB PhD student Clarissa Santoso, of the Fuxman Bass lab, and colleagues recently published a paper in Nucleic Acids Research. Their article, “Comprehensive mapping of the human cytokine gene regulatory network”, presents a large-scale resource of protein-DNA interactions between transcription factors and cytokine gene promoters. In particular, Clarissa and her team identified an enrichment of nuclear receptors which can be targeted with small molecules to modulate cytokine expression in the context of disease. This resource can also be leveraged to identify novel TF-cytokine regulatory axes in immune diseases and immune cell lineage development, as nicely illustrated in their paper. Read the paper here. Congratulations, Clarissa!