Cardiomyopathies are heart muscle disorders due to abnormal cardiomyocyte function. Our laboratory studies the mechanisms by which genetic variants lead to cardiomyopathy. We utilize bioengineered cardiac muscle bundles derived from human induced pluripotent stem cells (hiPSCs), mouse models, and human heart tissue. The primary long term goals of the lab are 1) to develop and translate novel treatments for cardiomyopathy, and 2) to improve disease modeling through engineering and genetic approaches that leverage the iPSC system.
