Faculty Research

The Graduate Program in Bioinformatics offers unique interdisciplinary training in the science, engineering, medicine and ethics of twenty-first-century systems biology. The Program is University-wide and includes Faculty from the Colleges of Engineering, Arts and Sciences, components of the Medical campus including the National Emerging Infectious Disease Laboratory (NEIDL), and adjunct faculty from major biotechnology companies, the Broad Institute, Harvard Medical School  and the National Institutes of Health. View the full list of Faculty ›

Daniel Segrè, Ph.D.
SegreProfessor, Bioinformatics
Professor, Biology,
Biomedical Engineering, Physics
Director, BU Microbiome Initiative, Co-Director, BU ARC on Systems Biology of Microbiomes

Dr. Segrè’s laboratory research interests focus on the evolutionary dynamics of biological networks, in particular in the interplay between response to genetic and environmental perturbations, genomic-level functional organization, and optimal adaptation. His research lab is especially interested in developing constraint-based models to study the regulatory and evolutionary dynamics of metabolic networks across different organisms, cell types, and interacting cell populations.

Research Interests
• Computational Systems Biology
• Evolutionary Dynamics of Biochemical Networks
• Microbial Metabolism
• Origins of Life and Bioenergetics

Josh Campbell, Ph.D.

Assistant Professor, Division of Computational Biomedicine
Assistant Professor, Bioinformatics

Research Interests
• Computational biology and bioinformatics
• Identifying early drivers of lung cancer
• Therapeutic development and pathogenesis of COPD


Dr. Campbell’s laboratory’s research focus is to understand the effect of carcinogenic exposures on the airway, elucidate the mechanisms that cause the development of pre-cancerous lesions in the lung, and to uncover the biological underpinnings of cancer disparities. Dr. Campbell is also an alumnus of  our PhD Graduate Program Bioinformatics.

Kirill Korolev, Ph.D.
KorolevAssociate Professor, Bioinformatics
Associate Professor, Physics

Research Interests
• Evolutionary Dynamics of Cancer
• Early Warning Signals of Population Collapse
• Evolution of Microbial Populations

Korolev Research Group›


Avrum Spira, M.D., M.Sc.
SpiraProfessor of Medicine, Pathology and Laboratory Medicine
Professor of Bioinformatics
Director, Boston University – Boston Medical Center Cancer Center
Chief, Division of Computational Biomedicine
Director, Translational Bioinformatics Program, Clinical and Translational Science Institute

Dr. Spira’s laboratory research interests focus on applying high-throughput genomic and bioinformatics tools (including microarrays and RNA-seq) to the translational study of lung cancer and Chronic Obstructive Lung Disease (COPD).  The primary research focus of his lab is to determine how cigarette smoking affects intra-thoracic (lobar bronchi and lung parenchyma) and extra-thoracic (mouth and nasal) airway epithelial cell gene expression and to use this information to develop non-invasive genomic biomarkers for lung cancer (and other smoking-related lung diseases) that can identify that subset of smokers at risk and potentially guide therapeutic and preventive strategies for these diseases.  With a $13.6 million grant from the Department of Defense awarded in 2011, Dr. Spira is carrying the research forward as leader of a five-year study called Detecting Early Lung Cancer Among Military Personnel (DECAMP). Dr. Spira is also an alumnus of  our MS Graduate Program Bioinformatics.

Research Interests
• Lung Cancer and COPD Genomics
• Smoking and Airway Gene Expression
• Bioinformatics
• Critical Care Medicine
• Pulmonary Medicine