Graduate Prerequisites: (ENGBE605) BE 605 and graduate standing in BME department, or permission of instr uctor. - This course is a primary literature-based course that will introduce students to engineering concepts in understanding and manipulating the behavior of biological cells. We will try to understand the interplay between cells, the extracellular environment, and intracellular signaling pathways in regulating cellular and multicellular structure and function. In particular, we will explore the use of modern experimental approaches to characterize and manipulate cells for bioengineering applications, and the concepts in scaling cellular engineering to functional issues. In this context, we will focus on several topics, including signal transduction and the molecular regulation of cell function, cellular microenvironment, cell adhesion and mecghanics, stem cells, multicellularity, and experimental models of tissue development. We will introduce both classic approaches and those that are still in early development. Due to the expansive nature of this area of science, we will only be able to introduce a sampling of the space.

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