This course provides an overview of the important concepts fundamental to the understanding, design, and conduct of cancer epidemiology studies. The course commences with the descriptive epidemiology of cancer, including time trends in incidence and mortality, and geographic and demographic variation in cancer rates. An overview of the biology of cancer, and a review of the major epidemiologic concepts critical to cancer epidemiology is covered. The descriptive and analytic epidemiology of major cancer sites, including breast, lung, colon, prostate, and cervix, is discussed, as well as major risk factors for cancer, including tobacco, nutrition, infections, and health disparities. The course format consists of a series of lectures by faculty and guests, discussion sessions, and directed readings from the current literature, as well as a literature review and final group presentation. Students may not take both EP752 and EP735 for degree credit.