Excellence in physical therapy practice necessitates the incorporation of scientific evidence, clinical expertise, and patient values and expectations into decision-making. This course will focus on the appraisal of scientific evidence related to the synthesis of examination data (i.e., diagnosis) and the determination of the plan of care (i.e., prognosis). You will walk away from this course knowing how to ask focused questions related to these elements of clinical practice, appraise the associated literature, and use this evidence to enhance the care you provide patients and clients. We will also explore how qualitative research informs clinical practice differently from quantitative methods.