This course provides a dynamic introduction to the health sector, beginning with the burden and distribution of disease and current patterns of expenditures. While the primary emphasis will be on the U.S. healthcare system, a global context will be developed. The basic elements of insurance and payment, service organization and delivery, and life sciences products (drugs, biologics, diagnostics, and devices) will be described, and placed in the context of the unique economic structure of the sector. The intense challenges of the sector will be explored, including ethical, social and organizational dilemmas that arise as well as business opportunities that emerge. The roles that government policy, rapid technology growth, and practice development play as drivers of system change will be addressed throughout.