Prereq: GMS BI 755, 756 or equivalent and consent of instruc-tor. Advanced aspects of chemical, thermodynamic and kinetic principles of catalytic mechanisms. Topics include genetic, kinetic, and chemical methods of analysis of enzyme mechanisms; transition state and mechanism-based inhibitors in the control of metabolic reactions; allosteric regulation; enzymes as chemotherapeutic targets in human disease. Offered alternate years. 2 cr, 2nd sem.