This course is designed to be an introduction to cancer biology and oncology from the perspective of the engineer. The course will cover basic cancer biology including cancer genetics, tumor metabolism, angiogenesis, and the metastastic cascade, and then discuss how new technologies enable better diagnosis, prognosis, and treatment. The class will explore how engineering principles can be applied to the design and fabrication of new technologies for cancer care, with an emphasis on signal processing, image formation (i.e. tomography), and data analysis. There will be a strong imaging component relevant to both cancer biology and clinical treatment, including optical, MRI, mammography, and PET-CT modalities. The course will be a combination of traditional lectures, class discussions, and journal club, and each student will be expected to present several times during the semester.