Cell metabolism, with special emphasis on the uptake of food materials, the integration and regulation of catabolic, anabolic, and anaplerotic routes, and the generation and utilization of energy. Lectures include consideration of events in prokaryotic and eukaryotic organisms. Polysaccharides, energy storage and recognition; intermediary metabolism; lipid and isoprene metabolism; nitrogen metabolism; nucleotide metabolism; macromolecular biosynthesis with emphasis on specificity and fidelity in the mechanisms of RNA, DNA, and proteins synthesis. Three hours lecture, four hours laboratory, one hour discussion. Same as GRS BI 622. Lecture and laboratory meet with CAS BI/CH 422.