This is a foundational course in infectious diseases for students pursuing a career in public health practice that involves working to control, prevent, eliminate, and/or eradicate these diseases. In the first week of class, students learn basic principles of infectious disease causation and spread. In subsequent weeks, they apply those principles to analyze how agent, host, and environmental (physical, social, behavioral, cultural, economic, political) factors impact the transmission and clinical course of infection, and contribute to the susceptibility and vulnerability of individuals and populations. Students then use this information to analyze the effectiveness of key public health infectious disease control and prevention strategies, and to identify and propose their own intervention strategies. Through a combination of active learning and problem solving, students recognize that addressing infectious disease problems requires consideration of not only the natural history of a disease, but also policy-based decision making, resources and economics, and the ecological, social behavioral and cultural context of disease settings. They learn that designing and implementing contextually appropriate and effective infectious disease control and prevention interventions requires a multi-disciplinary and multi-sectorial, One Health, approach.