This is an advanced level seminar course. It focuses on areas of active controversy regarding past and current eradication/control campaigns. This class will consider the biological, epidemiological, sociological, political, ethical, and programmatic features that allowed the smallpox eradication campaign to succeed. Other diseases that are currently candidates for global eradication campaigns that will be covered in this class include polio, measles, malaria, lymphatic filariasis, onchocerciasis, and dracunculiasis. Public health policy decisions ultimately rest on basic and clinical scientific research. This course approaches this topic through a series of focused readings drawn from the primary scientific literature. The goal is to prepare students to better participate in these debates themselves.