Interfaces between humans and machines have matured beyond science fiction, and now offer a unique opportunity to restore lost sensory or motor function. This case-based course will explore the physiology of healthy and impaired sensorimotor systems, engineering approaches to rehabilitate or replace function, and the impact of these technologies on end-users and society at large. Students will complete a semester-long project including written reports and oral presentations. Discussions will focus on specific applications of human-machine-interfaces for health, concentrating on design specifications and long-term impact. Applications include: cochlear implants, retinal implants, upper and lower limb prostheses, brain-computer-interfaces for augmentative communication, rehabilitation robotics, and functional electric stimulation after spinal cord injury. CAS Divisional Assignment: NS without lab; KHC Assignment: STEM