This course consists of lectures and discussions on major classes of pharmacological agents, with special attention to systems mechanisms of therapeutic and adverse effects, including molecular, cellular, physiologic, psychological, and pathologic phenomenon. Starting from a basic review of current therapeutics in a particular disease area, students will be encouraged to anticipate new developments in the field and to propose solutions for solving problems with current pharmacological approaches. The course focuses on cardiovascular, endocrine, and steroid pharmacology and chemotherapy for inflammation, cancer, and bacterial and viral infections. 2 cr, Spring sem.