Prereq: at least one semester each of Biochemistry and Physiology and permission of the instructor. Regulation of lipid, carbohydrate, and protein digestion, absorption, transport, tissue and cellular metabolism. Integration of macronutrient metabolism in response to alteration in nutritional status (e.g. starvation, obesity) on a whole body and tissue-specific basis. Mechanism regulating macronutrient metabolism in response to stresses such as exercise and aging and disease. A discussion session will teach students to critically evaluate research papers, provide knowledge of seminal papers in the field, and introduce students to research approaches and state of the art methods (e.g. assessment of metabolic flux using stable isotopes, euglycemic clamps, metabolomics). Fried. 4 cr, Spring sem.