This course provides an overview of the basic concepts of medical informatics. Fundamentals of biology and medicine are covered via a computing and information oriented treatment of the main concepts of human biology. Biological structure and function is presented at three levels or organization: organism, cell, and gene. Each level includes examples of principal anatomic and physiologic concepts, presented from a computational perspective. The course further covers the main computational methods in biomedicine. Topics include introduction to bioinformatics, clinical information systems, medical imaging systems and biomedical data mining.. Topics in security, confidentiality and privacy of medical information systems are also presented, such as medical data assurance, biometrics and privacy protection techniques.