Nanotechnology is emerging as the technology of the 21st century. There is an ever growing effort by scientists and engineers across disciplines to envision, fabricate and integrate nanoscale devices for countless applications. This course will give a rigorous introduction to the basic concepts and experimental techniques in nanoscience and nanotechnology. The course will review relevant quantum mechanics and solid state physics as a basis for understanding the physical phenomena at the nanoscale. Then, basic issues in nanofabrication, Scanning Probe Microscopy (SPM), nanoelectronics and nanomechanics will be discussed.