This course will provide a critical review of current research topics in proteomics and systems biology. Emphasis will be placed on protein engineering (gross structural modifications, pathway perturbations, and biomedical applications including therapeutics and diagnostics) and genome engineering (knockout strains, conditional knockouts, and bioproductions optimization). Topics covered will include: mass spectrometry, protein microarrays, protein complex and interaction discovery, uses of antibodies as reagents and therapeutics, and pathway and network analyses.